Abstract
The morbidity; mortality, and cost of involutional osteoporosis result largely from the associated fractures,1 and pathogenesis must be considered in that context (Figure 7.1). This chapter will review the determinants of bone fragility that result from low peak bone mass and from subsequent bone loss due to the menopause in women, to aging in both genders, and to the various causes of secondary osteoporosis. The role of trauma will be described as it relates to the frequency and severity of falls. Finally, the heterogeneity of osteoporosis syndromes will be discussed, with emphasis on current concepts of Type I (postmenopausal) and Type II (age-related) osteoporosis.
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References
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© 1994 Springer-Verlag New York, Inc.
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Melton, L.J. (1994). Pathogenesis of Osteoporosis. In: Lorrain, J., Plouffe, L., Ravnikar, V.A., Speroff, L., Watts, N.B. (eds) Comprehensive Management of Menopause. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4330-4_8
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DOI: https://doi.org/10.1007/978-1-4612-4330-4_8
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