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Psychobiological Aspects of the Menopause

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Comprehensive Management of Menopause

Part of the book series: Clinical Perspectives in Obstetrics and Gynecology ((CPOG))

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Abstract

From the point of view of a practitioner in a menopause clinic, it is evident that a high proportion of climacteric women present with symptoms of a psychological nature.1 Because of this phenomenon, it was popularly believed that there was necessarily a link between menopause itself and the etiology of psychological symptoms. Indeed, such symptoms were often conceptualized as a component of the syndrome. This was particularly true for depression, which was often listed as a menopausal symptom.

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References

  1. Ballinger CB. Psychiatric morbidity and the menopause: survey of a gynaecological outpatient clinic. Br J Psychiatry. 1977; 131: 8389.

    Article  Google Scholar 

  2. Weigsman MM. The myth of involutional melancholia. JAMA 1979; 242: 742–744.

    Article  Google Scholar 

  3. Neugarten BL, Wood V, Kraines RJ, et. al. Women’s attitudes toward the menopause. In: Neugarten BL, ed. Middle Age and Aging. Chicago: University of Chicago Press, 1965: 195–200.

    Google Scholar 

  4. Thompson B, Hart SA; Durno D. Menopausal age and symptomatology in a general practice. J Biosoc Sci 1973; 5: 71–82.

    Article  PubMed  CAS  Google Scholar 

  5. McKinlay SM, McKinlay JB. Selected studies of the menopause. J Biosoc Sci 1973; 5: 533555.

    Google Scholar 

  6. McKinlay SM, Jefferys M. The menopausal syndrome. BrJ Prey Soc Med 1974; 28: 108–115.

    CAS  Google Scholar 

  7. McKinlay JB, McKinlay SM, Brambilla DJ. Health status and utilization behavior associated with menopause. Am J Epidemiol 1987; 125: 110–121.

    PubMed  CAS  Google Scholar 

  8. Jaszmann L, Van Lith ND, Zaat JCA. The perimenopausal syndrome: the statistical analysis of a survey. Medical Gynaecology and Sociology 1969; 4: 268–267.

    Google Scholar 

  9. Bungay GT, Vessey MP, McPherson CK. Study of symptoms in middle life with special reference to the menopause. Br Med J 1980; 281: 181–183.

    Article  PubMed  CAS  Google Scholar 

  10. Hallstrom T. Mental Disorder and Sexuality in the Climacteric. Gothenbury: Scandinavian University Books, 1973:

    Google Scholar 

  11. Ballinger CB. Psychiatric morbidity and the menopause, screening of general population sample. Br Med J 1975; 3: 344–346

    Article  PubMed  CAS  Google Scholar 

  12. Ballinger CB. Psychiatric aspects of the menopause [see comments]. Br J Psychiatry 1990; 126: 773–787.

    Article  Google Scholar 

  13. Dennerstain L, Burrows GD. A review of studies of the psychological symptoms found at the menopause. Maturitas 1978; 1: 55–64.

    Article  Google Scholar 

  14. Weissman MM, Klerman GL. Sex differences and the epidemiology of depression. Arch Gen Psychiatry 1977; 34: 98–111.

    Article  PubMed  CAS  Google Scholar 

  15. Sainsbury P. Psychosmatic disorders and neurosis in outpatients attending a general hospital. J Psychosom Res 1988.

    Google Scholar 

  16. Gath D. Osborn M, Bungay G, et al. Psychiatric disorder and gynaecological symptoms in middle aged women: a community survey Br Med J (Clin Res Ed) 1987; 294: 213–228.

    CAS  Google Scholar 

  17. Worsley A, Walters WA, Wood EC. Responses of Australian patients with gynaecological disorders to the General Health Questionnaire: a factor analytic study. Psychol Med 1978; 8: 131–138.

    Article  PubMed  CAS  Google Scholar 

  18. Byrne P. Psychiatric morbidity in a gynaecology clinic an epidemiological survey. Br J Psychiatry 1984; 144: 28–34.

    Article  PubMed  CAS  Google Scholar 

  19. Hammar M, Berg G, Frahraeus L, LarssonCohn U. Climacteric symptoms in an unselected sample of Swedish women, Maturitas 1984; 6: 345–350.

    Article  PubMed  CAS  Google Scholar 

  20. Kaufert PA, Gilbert P, Tate R. The Manitoba Project: a-re-examination of the link between menopause and depression [see comments]. Maturitas 1992; 14: 143–155.

    Article  PubMed  CAS  Google Scholar 

  21. Hunter M. The south-east England longitudi nal study of the climacteric and postmeno pause [see comments]. Maturitas 1992; 14: 117–126.

    Article  PubMed  CAS  Google Scholar 

  22. Chakravarti S, Collins WP, Thom MH, Studd JW. Relation Between Plasma hormone pro files, symptoms, and repsonse to oestrogen treatment in women approaching the meno pause. Br Med J. 1979; 1: 983–985.

    Article  PubMed  CAS  Google Scholar 

  23. Channon LD, Ballinger SE. Some aspects of 37. sexuality and vaginal symptoms during meno pause and their relation to anxiety and depres sion. Br J Med Psychol. 1986; 59: 173–180.

    Article  PubMed  Google Scholar 

  24. Hunter M, Battersby R, Whitehead M. Rela- tionships between psychological symptoms, somatic complaints and menopausal status. Maturitas. 1986; 8: 217–228.

    Article  PubMed  CAS  Google Scholar 

  25. McCraw RK. Psychosexual changes associated with the perimenopausal period. J Nurse Mid wifery 1991; 36: 17–24.

    Article  CAS  Google Scholar 

  26. Notman MT. The displaced homemaker: a crisis of later life. The midlife years and after: opportunities and limitations: clinical issues. J Geriatr Psychiatry. 1982; 15: 173–191.

    PubMed  CAS  Google Scholar 

  27. Sherman BM, West JH, Korenman SG. The menopausal transition: analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women. J Clin Endocrinol Metab. 1976; 42: 629–636.

    Article  PubMed  CAS  Google Scholar 

  28. Holte A, Mikkelsen A. Psychosocial dete- minants of climacteric complaints. Maturitas. 1991; 13: 205–215.

    Article  PubMed  CAS  Google Scholar 

  29. Costello EJ. Married with children: predic tors of mental and physical health in middle- aged women. Psychiatry. 1991; 54: 292–305.

    PubMed  CAS  Google Scholar 

  30. Abe T, Moritsuka T. Psychosocial back grounds of climacteric symptoms and com plaints. Nippon Sanka Fujinka Gakkai Zas- shi. 1986; 38: 2143–2151.

    CAS  Google Scholar 

  31. Deykin EY, Jacobson S, Klerman G, Solomon M. The empty nest: psychosocial aspects of conflict between depressed women and their grown children. Am J Psychiatry. 1966; 122: 1422–1426.

    PubMed  CAS  Google Scholar 

  32. Vagogne A. The experience of the menopause. Rev Fr Gynecol Obstet. 1985; 80: 191–194.

    PubMed  CAS  Google Scholar 

  33. Benedek T. Climacterium: a developmental phase. Psychoanal Quart. 1950; 19: 1–17.

    Google Scholar 

  34. Backstrom T, Bixo M, Hammarback S. Ovar ian steroid hormones. Effects on mood, be haviour and brain excitability. Acta Obstet Gynecol Scand. 1985; 130 (suppl): 19–24.

    Article  CAS  Google Scholar 

  35. McEwen BS. Basic research perspective: ova-rian hormone influence on brain neurochem-ical functions. In: Gise LH, Kase NG, Berko-witz RL, eds. The Prementstrual Syndromes.New York: Churchill Livingstone; 1988: 21–34.

    Google Scholar 

  36. Backstrom T, Hammarback S, Johansson U,Bixo M. The pathogenesis of premenstrual syndrome. In: Demers LM, McGuire JL, Phil-lips A, Rubinow DR, eds. Premenstrual, Post-partum, and Menopausal Mood Disorders. Baltimore-Munich: Urban & Schwarzenberg, Inc.; 1989: 19–34.

    Google Scholar 

  37. Rausch JL, Janowsky DS. Premenstrual Ten-sion: Etiology. In: Friedman R, ed. Behavior and the Menstrual Cycle. New York: Marcel Dekker; 1982: 397–427.

    Google Scholar 

  38. Bernardi M, Sandrini M, Vergoni AV, Mar-rama D, Tagliavini S, Bertolini A. Influence of gonadotropin-releasing hormone on castra-tion-induced `depression’ in mice: a behav-ioral and binding study. Eur J Pharmacol. 1990; 187: 501–506.

    Article  PubMed  CAS  Google Scholar 

  39. Chakravarti S, Collins WP, Newton JR, Oram DH, Studd JW. Endocrine changes and sym-tomatology after oophorectomy in premeno-pausal women. Br J Obstet Gynaecol. 1977; 84: 769–775.

    Article  PubMed  CAS  Google Scholar 

  40. Bernardi M, Vergoni AV, Sandrine M, Taglia-vini S, Bertolini A. Influence of ovariectomy,estradiol and progesterone on the behavior of mice in an experimental model of depression. Asberg M, Wagner A. Biochemical effects of Physiol Behay. 1989; 45: 1067–1068.

    CAS  Google Scholar 

  41. Asberg M, Wagner A. Biochemicas effects of antidepressant treatment studies of mono- amine metabolites in cerebrospinal fluid andplatelet [3H]imipramine binding. Ciba Found Symp. 1986; 123: 57–83.

    PubMed  CAS  Google Scholar 

  42. Langer SZ, Galzin AM, Lee CR, Schoemaker H. Antidepressant-binding sites in brain and platelets. Ciba Found Symp. 1986; 123: 3–29.

    PubMed  CAS  Google Scholar 

  43. Roy A, Everett D, Pickar D, Paul SM. Platelet tritiated imipramine binding and serotonin uptake in depressed patients and controls. Relationship to plasma cortisol levels before and after dexamethasone administration. Arch Gen Psychiatry. 1987; 44: 320–327.

    Article  PubMed  CAS  Google Scholar 

  44. Sherwin BB, Suranyi-Cadotte BE. Up-regula-tory effect of estrogen on platelet 3H-imipra-mine binding sites in surgically menopausal women. Biol Psychiatry. 1990; 28: 339–348.

    Article  PubMed  CAS  Google Scholar 

  45. Guicheney P, Leger D, Barrat J, et al. Platelet serotonin content and plasma tryptophan in peri-and postmenopausal women: variations with plasma oestrogen levels and depressive symptoms. Eur J Clin Invest. 1988; 18: 297–304.

    Article  PubMed  CAS  Google Scholar 

  46. Chomicka LK. Effect of oestradiol on the doses of responses of regional brain serotonin to stress in the ovariectomized rat. J Neural Transm. 1986; 67: 267–273.

    Article  PubMed  CAS  Google Scholar 

  47. Ballinger CB, Browning MC, Smith AH. Hor- one-peri-menopausal women. Maturitas. 1987; 9: 235–251.

    Article  PubMed  CAS  Google Scholar 

  48. Ballinger S, Cobbin D, Krivanek J, Saunders stresses and depression in the menopause. Maturitas. 1979; 1: 191–199.

    Article  PubMed  CAS  Google Scholar 

  49. De Lignieres B, Vincens M. Differential ef 1979;1:247–259. fects of exogenous oestradiol and progester- PL, Hailes J. The one on mood in post-menopausal women: in dividual dose/effect relationship. Maturitas. 1982; 4: 67–72.

    Google Scholar 

  50. Holst J, Backstrom T, Hammarback S, von use Schoultz B. Progestogen addition during oestrogen replacement therapy-effects on vasomotor symptoms and mood. 1989; 11: 13–20.

    CAS  Google Scholar 

  51. Sherwin BB. The impact of different estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metab. 1991; 72: 336–343.

    Article  PubMed  CAS  Google Scholar 

  52. Sherwin BB, Gelfand MM. A prospective mone profiles and psychological symtoms in year study of estrogen and progestin in post-menopausal women: effects on clinical symp-toms and lipoprotein lipids. Obstet Gynecol. 1989; 73: 759–766.

    PubMed  CAS  Google Scholar 

  53. Dennerstein L, Burrows GD, Hyman GJ, Sharpe K. Hormone therapy and affect. Maturitas. 1979; 1: 247–259.

    Article  PubMed  CAS  Google Scholar 

  54. Schneider MA, Brotherton Sharpe K. Hormone therapy and affect. Ma-turitas.effect of exogenous oestrogens on depression in menopausal women. Med J Aust. 1977; 2: 162–163.

    PubMed  CAS  Google Scholar 

  55. Palinkas LA, Barrett-Connor E. Estrogen and depressive symptoms in postmenopausal women. Obstet Gynecol. 1992; 80: 30–36.

    PubMed  CAS  Google Scholar 

  56. Dennerstein L. Depression in the menopause.Obstet Gynecol Clin North Am. 1987; 14: 33–48.

    CAS  Google Scholar 

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Authors
  1. Jeffrey L. Rausch
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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Université de Montréal, Hôpital du Sacré-Coeur de Montréal, H4J 1C5, Montréal, Quebec, Canada

    Jacques Lorrain M.D., FRCS(C), FACOG (Clinical Professor, Director) (Clinical Professor, Director)

  2. Gynecological Endocrinology and Reproductive Medicine, Hôpital du Sacré-Coeur de Montréal, H4J 1C5, Montréal, Quebec, Canada

    Jacques Lorrain M.D., FRCS(C), FACOG (Clinical Professor, Director) (Clinical Professor, Director)

  3. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics-Gynecology, Medical College of Georgia, 30912-3360, Augusta, GA, USA

    Leo Plouffe Jr. M.D. (Associate Professor/Director of Clinical Services) (Associate Professor/Director of Clinical Services)

  4. University of Massachusetts Medical Center, 01655, Worcester, MA, USA

    Veronica A. Ravnikar M.D. (Professor of Obstetrics and Gynecology, Director of Reproductive Endocrinology, Fertility, Menopause) (Professor of Obstetrics and Gynecology, Director of Reproductive Endocrinology, Fertility, Menopause)

  5. Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health Sciences University School of Medicine, 97201-3098, Portland, OR, USA

    Leon Speroff M.D. (Professor and Chairman) (Professor and Chairman)

  6. Division of Endocrinology, Department of Medicine, The Emory University School of Medicine, 30322, Atlanta, GA, USA

    Nelson B. Watts M.D. (Associate Professor) (Associate Professor)

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© 1994 Springer-Verlag New York, Inc.

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Rausch, J.L. (1994). Psychobiological Aspects of the Menopause. In: Lorrain, J., Plouffe, L., Ravnikar, V.A., Speroff, L., Watts, N.B. (eds) Comprehensive Management of Menopause. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4330-4_30

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  • DOI: https://doi.org/10.1007/978-1-4612-4330-4_30

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8737-7

  • Online ISBN: 978-1-4612-4330-4

  • eBook Packages: Springer Book Archive

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