TGF-β Inhibition of Intestinal Epithelial Cell Proliferation: G1 Cyclins, Cyclin-Dependent Kinases, and Cyclin Kinase Inhibitors

  • E. Aubrey Thompson
  • Tien C. Ko
  • R. Daniel Beauchamp
Part of the Hormones in Health and Disease book series (HHD)


Colon carcinogenesis is a multistep process involving alterations in the normal replication of intestinal epithelial cells Vogelstein et al., 1988; Cameron et al., 1990; Vogelstein, 1990. In recent years, there has been a significant increase in our understanding of the basic molecular mechanisms that underlie regulation of cell proliferation. This new insight has provided a clearer picture of gut epithelial cell replication and of the changes that lead to breakdown of these regulatory mechanisms during tumor initiation or progression. Anßsis of gut epithelial cell proliferation also promises to provide fundamental new insight into hormonal inhibition of cell proliferation and into the relationship between hormone insensitivity and transformation.


Intestinal Epithelial Cell Esophageal Epithelial Cell Cyclin Kinase Inhibitor Intestinal Cell Proliferation Intestinal Epithelial Cell Proliferation 
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Copyright information

© Birkhäuser Boston 1996

Authors and Affiliations

  • E. Aubrey Thompson
  • Tien C. Ko
  • R. Daniel Beauchamp

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