TGF-β Inhibition of Intestinal Epithelial Cell Proliferation: G1 Cyclins, Cyclin-Dependent Kinases, and Cyclin Kinase Inhibitors

  • E. Aubrey Thompson
  • Tien C. Ko
  • R. Daniel Beauchamp
Part of the Hormones in Health and Disease book series (HHD)

Abstract

Colon carcinogenesis is a multistep process involving alterations in the normal replication of intestinal epithelial cells Vogelstein et al., 1988; Cameron et al., 1990; Vogelstein, 1990. In recent years, there has been a significant increase in our understanding of the basic molecular mechanisms that underlie regulation of cell proliferation. This new insight has provided a clearer picture of gut epithelial cell replication and of the changes that lead to breakdown of these regulatory mechanisms during tumor initiation or progression. Anßsis of gut epithelial cell proliferation also promises to provide fundamental new insight into hormonal inhibition of cell proliferation and into the relationship between hormone insensitivity and transformation.

Keywords

Lymphoma Adenocarcinoma Adenoma Polypeptide Glutamine 

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© Birkhäuser Boston 1996

Authors and Affiliations

  • E. Aubrey Thompson
  • Tien C. Ko
  • R. Daniel Beauchamp

There are no affiliations available

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