Abstract
Methyl bromide is widely used as an insecticidal fumigant in food supplies, warehouses, barges, buildings, and furniture, and as a termiticide for dry-wood termites (Incisitermes spp.). Its popularity as a fumigant is largely attributable to its high toxicity to many pests, the variety of settings in which it can be applied, its ability to penetrate the fumigated substances, and its rapid dissipation following application (Alexeeff and Kilgore 1983). Methyl bromide is also used in fire extinguishers and refrigerant systems, and in the chemical industry as a methylating agent and an extraction solvent (Alexeeff and Kilgorc 1983; Merck Index 1983).
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References
Alexeeff, GV, Kilgore, WW (1983) Methyl bromide. Residue Rev 88: 101–153.
Anger, WK, Setzer, JV, Russo, JM, Brightwell, WS, Wait, RG, Johnson, BL (1981) Neurobehavioral effects of methyl bromide inhalation exposures. Scand J Work Environ Hlth 7 (Suppl. 4): 40–47.
Anonymous (1984) No evidence of methyl bromide carcinogenicity found by NTP panel. Pestic Toxic Chem News 13: 9–10.
Aspelin, AL (1994) Pesticide Industry Scale and Usage: 1992 and 1993 Market Estimates. USEPA 733-K-94-001 (June). 33 pp.
Barber, ED, Donish, WH, Mueller, KR (1981) Procedure for the quantitative measurement of the mutagenicity of volatile liquids in the Ames Salmonella/microsome assay. Mutat Res 90: 31–48.
Barnsley, EA, Young, L (1965) Biochemical studies of toxic agents: The metabolism of iodomethane. Biochem J 95: 77–81.
Blackburn, S, Carter, E, Hemphill, G, Phillips, H (1941) The methylation of wool with methyl sulphate and methyl halides. Biochem J 35: 627.
Blackburn, S, Phillips, H (1944) Experiments on the methylation and acctylation of wool, silk, fibroin, collagen, and gelatin. Biochem J 38: 171.
Bond, JA, Dutcher, JS, Medinsky, MS, Henderson, RF, Birnbaum, LS (1985) Disposition of (l4C)methyl bromide in rats after inhalation. Toxicol Appl Pharmacol 78: 259–267.
Boorman, GA, Hong, HL, Jameson, CW, Yoshitomi, K, Maronpot, RR (1986) Regression of methyl bromide-induced forestomach lesions in the rat. Toxicol Appl Pharmacol 86: 131–139.
Burek, JD, Nitschke, KD, Bell, TJ, Wackerle, DL, Childs, RC, Beyer, JE, Dittenber, DA, Rampy, LW, McKenna, MJ (1984) Methylene chloride: A two-year inhalation toxicity and oncogenicity study in rats and hamsters. Fund Appl Toxicol 4: 30–47.
Chellman, GJ, Bus, JS, Working, PK (1986) Role of epididymal inflammation in the induction of dominant lethal mutations in Fischer 344 rat sperm by methyl chloride. Proc Natl Acad Sci USA 83: 8087–8091.
Clarke, CA, Roworth, CG, Holling, HE (1945) Methyl bromide posioning. Br J Ind Med 2: 17–23.
Collins, RP (1965) Methyl bromide poisoning, a bizarre neurological disorder. Calif Med 103: 112–116.
Danse, LHJC, Van Velsen, FL, Van Der Heijden, CA (1984) Methyl bromide: Carcinogenic effects in the rat forestomach. Toxicol Appl Pharmacol 72: 262–271.
De Flora, S (1981) Study of 106 organic and inorganic compounds in the Salmonella/ microsome test. Carcinogenesis 2: 283–298.
DeKergommeaux, DJ, Grant, NVF, Sandhu, SS (1983) Clastogenic and physiological response of chromosomes to nine pesticides in the Vicia faba in vivo root tip assay system. Mutat Res 124: 69–84.
Djalali-Behzad, G, Hussain, S, Osterman-Golkar, S, Segerbaeck, D (1981) Estimation of genetic risks of alkylating agents. VI. Exposure of mice and bacteria to methyl bromide. Mutat Res 84: 1–9.
Dunkelberg, H (1980) Zur Problematik per Ansendung alkylierender Substanzen bei der Lebensmittelbegasung hinsichtlich der Bildung von Vorstufen der N-Nitrosoverbindungen. IL N-Methylierung verschiedner Aminosäuren durch Einwirkung von Methylbromide. Zbl Bakt Hyg I Abt Orig 171: 48.
Ehrenberg, L, Osterman-Golkar, S, Singh, D, Lundqvist, U (1974) On the reaction kinetics and mutagenic activity of methylating and 0-halogenoethylating gasoline additives. Radial Bot 15: 185–194.
Eustis, SL, Haber, SB, Drew, RT, Yang, RSH (1988) Toxicology and pathology of methyl bromide in F344 rats and B6C3F1 mice following repeated inhalation exposure. Fund Appl Toxicol 11: 594–610.
Florin, I, Rutberg, L, Curvall, M, Enzeil, CR (1980) Screening of tobacco smoke constituents for mutagenicity using the Ames test. Toxicology 15: 219–232.
Fostel, J, Allen, PF, Bermudez, E, Kligerman, AD, Wilmer, JL, Skopek, TR (1985) Assessment of the genotoxic effects of methyl chloride in human lymphoblasts. Mutat Res 155: 75–81.
Gargas, ML, Andersen, ME (1982) Metabolism of inhaled brominated hydrocarbons: Validation of gas uptake results by determination of a stable metabolite. Toxicol Appl Pharmacol 66: 55–68.
Gocke, E, King, MT, Eckhardt, K, Wild, D (J981) Mutagenicity of cosmetics ingredients licensed by the European communities. Mutat Res 90: 91–109.
Goldmacher, VS, Thilly, WG (1983) Formaldehyde is mutagenic for cultured human cells. Mutat Res 116: 417–422.
Hezemans-Boer, M, Toonstra, J, Meulenbelt, J, Zwaveling, JH, Sangster, B, van Vloten, WA (1988) Skin lesions due to exposure to methyl bromide. Arch Dermatol 124: 917–921.
Honma, T, Sudo, A, Miyagawa, M, Sato, M, Hasegawa, H (1982) Significant changes in monoamines in rat brain induced by exposure to methyl bromide. Neurobehav Toxicol Teratol 4: 521–524.
Honma, T, Sudo, A, Miyagawa, M, Sato, M, Hasegawa, H (1983) Changes in free amino acid contents of rat brain induced by exposure to methyl bromide. Toxicol Lett 15: 317–321.
Honma, T, Miyagawa, M, Sato, M, Hasegawa, H (1985) Neurotoxicity and metabolism of methyl bromide in rats. Toxicol Appl Pharmacol 81: 183–191.
Hunt, ME, Morgan, KT, Working, PK (1987) Histopathology of acute toxic responses in selected tissues from rats exposed by inhalation to methyl bromide. Fund Appl Toxicol 9: 352–365.
Hunt, ME, Working, PK (1988) Evaluation of spermatogenesis and sperm quality in the rat following acute inhalation exposure to methyl bromide. Fund Appl Toxicol 10: 490–498.
Hunt, ME, Thomas, DA, Working, PK, Monticello, TM, Morgan, KT (1988) Degeneration and regeneration of the olfactory epithelium following inhalation exposure to methyl bromide: Pathology, cell kinetics, and olfactory function. Toxicol Appl Pharmacol 94: 311–328.
Ikawa, N, Araki, A, Nozake, K, Matsushima, T (1986) Micronucleus test of methyl bromide by the inhalation method. Mutat Res 164: 269. (Abstract).
Irish, DD, Adams, EM, Spencer, HC, Rowe, VK (1940) The response attending exposure of laboratory animals to vapors of methyl bromide. J Ind Hyg Toxicol 22: 218–230.
Irish, DD, Adams, EM, Spencer, HC, Rowe, VK (1941) Chemical changes of methyl bromide in the animal body in relation to its physiological effects. J Ind Hyg Toxicol. 22: 408–411.
Jaskot, RH, Grose, EC, Most, BM, Menache, MG, Williams, TB, Roycroft, JH (1988) The distribution and toxicological effects of inhaled methyl bromide in the rat. J Am Coll Toxicol 7: 631–642.
Johnson, MK (1966) Studies on glutathione 5-alkyltranserase of the rat. Biochem J 98: 44–56.
Kornbrust, KJ, Bus, JS (1982) Metabolism of methyl chloride to formate in rats. Toxicol Appl Pharmacol 65: 135–143.
Kornbrust, KJ, Bus, JS (1983) The role of glutathione and cytochrome P-450 in the metabolism of methyl chloride. Toxicol Appl Pharmacol 67: 246–256.
Kowbel, DJ, Nestmann, ER, Malaiyandi, M, Helleur, R (1982) Determination of mutagenic activity in Salmonella of residual fulvic acids after ozonation. Water Res 16: 1537–1538.
Kramers, PGN, Bissumbhar, B, Mout, HCA (1985a) Studies with gaseous mutagens in Drosophtta melanogaster. In: Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV. Environ Sci Res 32: 65–73.
Kramers, PGN, Voogd, CE, Knaap, AGAC, van der Heijden, CA (1985b) Mutagenicity of methyl bromide in a series of short-term tests. Mutat Res 155: 41–47.
Lasne, C, Gu, ZW, Venegas, W, Chouroulinkov, I (1984) The in vitro micronucleus assay for detection of cytogenetic effects induced by mutagen-carcinogens: Comparison with the in vitro sister-chromatid exchange assay. Mutat Res 130: 273–282.
Leopold, WR, Miller, JA, Miller, EC (1982) Comparison of some carcinogenic, mutagenic, and biochemical properties of i-vinylhomocysteine and ethionine. Cancer Res 42: 4364–4374.
Lewis, SE (1948) Inhibition of SH enzymes by methyl bromide. Nature 161: 692–693.
Lund, PM, Cox, BS (1981) Reversion analysis of (psi) mutations in Saccharomyces cerevisiae. Gen Res 37: 173–182.
Maddy, KT, Edmiston, S, Richmond, D (1990) Illness, injuries, and deaths from pesticide exposures in California 1949–1988. Rev Environ Contain Toxicol 114: 57–123.
McGregor, DB (1981) Tier II Mutagenic Screening of 13 NIOSH Priority Compounds. Individual Compound Report: Methyl Bromide. Report Number 32. National Institute of Occupational Safety and Health, Cincinnati, OH.
Medinsky, MA, Dutcher, JS, Bond, JA, Henderson, RF, Mauderly, JL, Snipes, MB, Mewhinney, JA, Cheng, YS, Birnbaum, LS (1985) Uptake and excretion of [14C]methyl bromide as influenced by exposure concentration. Toxicol Appl Pharmacol 78: 215–225.
Merck & Co. Inc. (1983) Merck Index: An Encyclopedia of Chemicals. Drugs, and Biologicals. 10th ed., Merck & Co. Inc. Rahway, NJ, p. 865.
Miller, DP, Haggerd, HW (1943) Intracellular penetration of bromide as a feature in the toxicity of alhylo halide. J Ind Hyg Toxicol 25: 423–433.
Mitsumori, K, Maita, T, Kosaka, T, Miyaoka, T, Shirasu, Y (1990) Two-year oral chronic toxicity and carcinogenicity study in rats of diets fumigated with methyl bromide. Food Chem Toxicol 28: 109–119.
Miyagawa, M (1982) Conditioned taste aversion induced by inhalation exposure to methyl bromide in rats. Toxicol Lett 10: 411–416.
Mizyubova, IG, Bakhishev, CN (1971) Specific treatment of acute poisoning with methyl bromide. Original in Russian, translated by NIOSH 073087 Vrach Delo 7: 128–131.
Moriya, M, Ohta, T, Watanabe, K, Miyazawa, T, Kato, K, Shirasu, Y (1983) Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutat Res 116: 185–216.
National Institute for Occupational Safety and Health (NIOSH) (1984) Monohalo- methanes. Current Intelligence Bulletin 43. September 27.
National Toxicology Program (NTP) (1992) Toxicology and Carcinogenesis Studies of Methyl Bromide (CAS No. 74-83-9) in B6C3FI Mice (Inhalation Studies). NTP Technical Report No. 385. NIH Publication No. 92 - 2840. Research Triangle Park. NC and Bethesda, MD.
Nishimura, M, Umeda, M, Ishizu, S, Sato, M (1980) Effect of methyl bromide on cultured mammalian cells. J Toxicol Sci 5: 321–330.
Obe, G, Ristow, H (1977) Acetaldehyde, but not ethanol, induces sister chromatid exchanges in Chinese hamster cells in vitro. Mutat Res 56: 211–213.
Oya, Y, Yamamoto, K, Tomomura, A (1986) The biological activity of hydrogen peroxide. I. Induction of chromosome-type aberrations susceptible to inhibition by scavengers of hydroxyl radicals in human embryonic fibroblasts. Mutat Res 172: 245–253.
Reuzel, PGJ, Dreef-van der Meulen, HC, Hollanders, VMH, Kuper, CF, Feron, VJ, van der Heijden, OA (1991) Chronic inhalation toxicity and carcinogenicity study of methyl bromide in Wistar rats. Food Chem Toxicol 29: 31–39.
Russel, LB, Montgomery, CS (1980) Use of the mouse spot test to investigate the mutagenic potential of triclosan (Irgasan DP300). Mutat Res 79: 7–12.
Russo, JM, Anger, WK, Setzer, JV, Brightwell, WS (1984) Neurobehavioral assessment of chronic low-level methyl bromide exposure in the rabbit. J Toxicol Environ Hlth 14: 247–255.
Sheldon, T, Richardson, CR, Elliott, BM (1987) Inactivity of methylene chloride in the mouse bone marrow micronucleus assay. Mutagenesis 2: 57–59.
Shimizu, H, Suzuki, Y, Takemura, N, Goto, S, Matsushita, H (1985) The results of microbial mutation test for 43 industrial chemicals. Sangyo Igaku (Jpn J Ind Hlth) 27: 400–419.
Simmon, VF, Kauhanen, K, Tardiff, RG (1977) Mutagenic activity of chemicals identified in drinking water. Dev Toxicol Environ Sci 2: 249–258.
Singer, B, Fraenkel-Conrat, H (1974) Correlation between amino acid exchanges in coat protein of TMV mutants and the nature of the mutagens. Virology 60: 485–490.
Stark, AA, Zieger, E, Pagano, DA (1987) Glutathione mutagenesis in Salmonella lyphimurium TA100: Dependence on a single enzyme, 6-glutamyltranspeptidasc. Mutat Res 177: 45–52.
Storer, RD, Conolly, RB (1983) Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes. Carcinogenesis 4: 1491–1494.
Thilagar, AK, Kumaroo, V (1983) Induction of chromosome damage by methylene chloride in CHO cells. Mutat Res 116: 361–367.
Tomoda, R, Kusumoki, S, Nakashima, K, Matsunaga, T (1986) Use of a copper-phthalcocyanine membrane electrode for rapid preliminary detection of polycyclic mutagens. Mutat Res 164: 203–208.
Tonogai, Y, Ito, Y, Iwaida, M, Tati, M, Ose, Y, Sato, T (1979) Studies on the toxicity of coal tar dyes. 11. Examination of the biological reaction of C03l tar dyes to vital body. J Toxicol Sci 4: 211–220.
Trueman, RW, Ashby, J (1987) Lack of UDS activity in the livers of mice and rats exposed to dichloromethane. Environ Mutagen 10: 189–195.
Tucker, JD, Xu, J, Stewart, J, Baciu, PC, Ong, T (1986) Detection of sister chromatid exchanges induced by volatile genotoxicants. Teratogen, Carcinogen, Mutagen 6: 15–21.
Tuite, MF, Mundy, CR, Cox, BS (1981) Agents that cause a high frequency of genetic change from (psi +) to (psi -) in Saccharomyces cerevisiae. Genetics 98: 691–711.
United States Environmental Protection Agency (USEPA) (1984) Production/Eposure profile on methyl bromide. Office of Toxic Substances, USEPA, Washington. DC.
Van Den Oever, R, Roosels, D, Lahaye, D (1982) Acute hazard of methyl bromide fumigation in soil disinfection. Br J Ind Med 39: 140–144.
Ward, JB Jr, Hokanson, JA, Smith, ER, Chang, LW, Pereira, MA, Whorton, EB Jr, Legator, MS (1984) Sperm count, morphology and fluorescent body frequency in autopsy service workers exposed to formaldehyde. Mutat Res 130: 417–424.
Westbrook-Collins, B, Allen, JW, Kligerman, AD, Campbell, JA, Erexson, GL, Kari, F, Zeiger, E (1989) Dichloromethane-induced cytogenetic damage in mice. Environ Mol Mutagen 14 (Suppl 15): 217.
Winteringham, FPW (1955) The fate of labelled insecticide residues in food products. IV. The possible toxicological and nutritional significance of wheat fumigated with methyl bromide. J Sci Food Agric 6: 269.
Winteringham, FPW, Barnes, JM (1955) Comparative response of insects and mammals to certain halogenated hydrocarbons used as insecticides. Physiol Rev 35: 701.
Working, PK, Bus, JS, Hamm, TE Jr (1985) Reproductive effects of inhaled methyl chloride in the male Fischer 344 rat. 1. Mating performance and dominant lethal assay. Toxicol Appl Pharmacol 77: 133–143.
Working, PK, Bus, JS (1986) Failure of fertilization as a cause of preimplantation loss induced by methyl chloride in Fischer 344 rats. Toxicol Appl Pharmacol 86: 124–130.
Working, PK, Doolittle, DJ, Smith-Oliver, T, White, RD, Butterworth, BE (1986) Unscheduled DNA synthesis in rat tracheal epithelial cells, hepatocytes and spermatocyptes following exposure to methyl chloride in vitro and in vivo. Mutat Res 162: 219–224.
Zwaveling, JH, de Kort, WL Am, Meulenbelt, J, Hezemans-Boer, M, van Vloten, WA, Sangster, B (1987) Exposure of the skin to methyl bromide: A study of six cases occupationally exposed to high concentrations during fumigation. Hum Toxicol 6: 491–496.
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Yang, R.S.H., Witt, K.L., Alden, C.J., Cockerham, L.G. (1995). Toxicology of Methyl Bromide. In: Ware, G.W. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 142. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4252-9_3
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