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Lead and Neuropsychological Function in Children: Progress and Problems in Establishing Brain-Behavior Relationships

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Advances in Child Neuropsychology

Part of the book series: Advances in Child Neuropsychology ((CHILDNEUROPSYCH,volume 3))

Abstract

Lead is a ubiquitous environmental pollutant whose contribution to the pathogenesis of numerous human diseases has long been recognized, albeit not completely understood (NRC, 1993). Surprisingly, knowledge about lead’s devastating influence on the developing central nervous system dates only from the end of the nineteenth century (Gibson, Love, Hardine, Bancroft, & Turner, 1892). In their case series, a benchmark investigation in this literature, Byers and Lord (1943) demonstrated that lead poisoning need not progress to frank encephalopathy (i.e., cerebral edema and hemorrhage) for children to experience severe intellectual and behavioral sequelae. This discovery spawned worry over “low-level” or subclinical lead exposures, those within the range of exposures that may be incurred by residence in a modern industrial setting but not high enough to produce classic symptoms of lead poisoning. The hypothesis that such exposures impair children’s mental function has been a topic of spirited, often acrimonious debate since the 1970s.

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Authors
  1. David Bellinger
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Editors and Affiliations

  1. Division of Child and Adolescent Psychiatry, Vanderbilt University School of Medicine, 37212, Nashville, TN, USA

    Michael G. Tramontana Ph.D.

  2. Department of Psychiatry and the Clinical Center for the Study of Development and Learning, University of North Carolina School of Medicine, 27514, Chapel Hill, NC, USA

    Stephen R. Hooper Ph.D.

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© 1995 Springer-Verlag New York, Inc.

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Bellinger, D. (1995). Lead and Neuropsychological Function in Children: Progress and Problems in Establishing Brain-Behavior Relationships. In: Tramontana, M.G., Hooper, S.R. (eds) Advances in Child Neuropsychology. Advances in Child Neuropsychology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4178-2_2

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  • DOI: https://doi.org/10.1007/978-1-4612-4178-2_2

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  • Online ISBN: 978-1-4612-4178-2

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