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Ontogeny of the Endothelial Network Analyzed in the Avian Model

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Vascular Morphogenesis: In Vivo, In Vitro, In Mente

Part of the book series: Cardiovascular Molecular Morphogenesis ((CARDMM))

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Abstract

The avian embryo offers privileged approaches to experimental analyses of development, because of its accessibility, comparatively large size, deployment of the blastodisc in a plane, and last but not least, due to the “quail-chicken” marker system (Le Douarin, 1973). The latter approach consists in transplanting cells, rudiments, or territories from one species to the other, either in a heterotopic or orthotopic location, and tracing the cells from the transplant during their migration and differentiation. Tracing is accomplished either by identifying quail-specific, nucleolus-associated heterochromatin, or by applying antibodies that recognize all cells or a cell lineage from one of the two species; a variety of monoclonal antibodies (mAb) with such properties are now available. One mAb (MB1/QH1) has been particularly useful in the field of endothelial and blood cell ontogeny because it has affinity for the so-called “hemangioblastic” lineage in the quail. While mouse embryos may be engineered so as to reveal the critical gene activities involved in developmental processes, the unique amenability of bird embryos to microsurgery has made it possible to pin down the origins and migrations of precursors that build the vascular network.

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References

  • Auerbach R., Kubai L., Knighton D., Folkman J. (1974): A simple procedure for the long-term cultivation of chicken embryos. Dev Biol 41:391–394.

    Article  PubMed  CAS  Google Scholar 

  • Bagnall K.M. Higgins S. Sanders E.J. (1988): The contribution made by a single somite to the vertebral column: experimental evidence in support for resegmentation using the chick-quail chimaera model. Development 103:69–85.

    PubMed  CAS  Google Scholar 

  • Beaupain D., Martin C., Dieterlen-Lièvre F. (1979): Are developmental hemoglobin changes related to the origin of stem cells and site of erythropoiesis? Blood 53:212–225.

    PubMed  CAS  Google Scholar 

  • Brand-Saberi B., Seifert R., Grim M., Wilting J., Kuhlewein M., Christ B. (1995): Blood vessel formation in the avian limb bud involves angioblastic and angiotrophic growth. Dev Dyn 202:181–194.

    Article  PubMed  CAS  Google Scholar 

  • Carmeliet R, Ferreira V., Breier G., Pollefeyt S., Kieckens L., Gertsenstein M., Fahrig M., Vandenhoeck A., Harpal K., Ederhardt C., Declercq C., Pawling J., Moons L., Collen D., Risau W., Nagy A. (1996): Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435–139.

    Article  PubMed  CAS  Google Scholar 

  • Chevallier A., Kieny M., Mauger A. (1977): Limb-somite relationship: origin of the limb musculature. J Embryol Exp Morphol 41:245–258.

    PubMed  CAS  Google Scholar 

  • Christ B., Ordahl C.P. (1995): Early stages of chick somite development. Anat Embryol 191:381–396.

    Article  PubMed  CAS  Google Scholar 

  • Clark E.R. (1918): Studies on the growth of blood vessels in the tail of the frog larva by observation and experiment on the living animal. Am J Anat 23:37–88.

    Article  Google Scholar 

  • Coffin J.D., Poole T.J (1988): Embryonic vascular development: immunohistochemical identification of the origin and subsequent morphogenesis of the major vessel primordia. Development 102:735–748.

    PubMed  CAS  Google Scholar 

  • Coffin J.D., Harrison J., Schwartz S., Heimark R. (1991): Angioblast differentiation and morphogenesis of the vascular endothelium in the mouse embryo. Dev Biol 148:51–62.

    Article  PubMed  CAS  Google Scholar 

  • Coltey M., Jotereau F.V., Le Douarin N.M. (1987): Evidence for a cyclic renewal of lymphocyte precursor cells in the embryonic chick thymus. Cell Diff 22:71–82.

    Article  CAS  Google Scholar 

  • Couly G., Coltey P., Eichmann A., Le Douarin N.M. (1995): The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels. Mech Dev 53:97–112.

    Article  PubMed  CAS  Google Scholar 

  • Cuadros M.A., Moujahid A., Quesada A., Navascués J. (1994): Development of microglia in the quail optic tectum. J Comp Neurol 346:1–18.

    Article  Google Scholar 

  • Dieterlen-Liévre F. (1994): Hematopoiesis during avian ontogeny. Poultry Scev 5:273–305.

    Google Scholar 

  • Dieterlen-Liévre F., Martin C. (1981): Diffuse intraembryonic hematopoiesis in normal and chimeric avian development. Dev Biol 88:180–191.

    Article  PubMed  Google Scholar 

  • Drake C.J., Davis L.A., Walters L., Little C.D. (1990): Avian vasculogenesis and the distribution of collagens I, IV, laminin and fibronectin in the heart primordia. J Exp Zool 255:309–322.

    Article  PubMed  CAS  Google Scholar 

  • Drake C.J., Davis L.A., Little C.D. (1992): Antibodies to (31-integrins cause alterations of aortic vasculogenesis, in vivo. Dev Dyn 193:83–91.

    Article  PubMed  CAS  Google Scholar 

  • Drake C.J., Cheresh D.A., Little C.D. (1995): An antagonist of integrin alpha (v) beta (3) prevents maturation of blood vessels during embryonic neovascularization. J Cell Sci 108:2655–2661.

    PubMed  CAS  Google Scholar 

  • Eichmann A., Marcelle C., Breant C., Le Douarin N.M. (1993): Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development. Mech Dev 42:33–48.

    Article  PubMed  CAS  Google Scholar 

  • Eichmann A., Marcelle C., Breant C., Le Douarin N.M. (1996): Molecular cloning of Quekl and 2, two quail vascular endothelial growth factor (VEGF) receptor-like molecules. Gene 174:3–8.

    Article  PubMed  CAS  Google Scholar 

  • Emmel V.E. (1916): The cell clusters in the dorsal aorta of mammalian embryos. Am J Anat 19:401–421.

    Article  Google Scholar 

  • Evans H.M. (1909): On the development of the aorta, cardinal and umbilical veins, and other blood vessels of embryos from capillaries. Anat Rec 3:498–518.

    Article  Google Scholar 

  • Flamme I. (1989): Is extraembryonic angiogenesis in the chicken embryo controlled by the endoderm? Anat Embryol 180:259–272.

    Article  PubMed  CAS  Google Scholar 

  • Flamme I., Risau W. (1992): Induction of vasculogenesis and hematopoiesis in vitro. Development 116:435–439.

    PubMed  CAS  Google Scholar 

  • Folkman J. (1974): Tumour angiogenesis. Adv Cancer Res 19:331–358.

    Article  PubMed  CAS  Google Scholar 

  • Fong G.H., Rossant J., Gertsenstein M., Breitman M.L. (1995): Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66–70.

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Martinez V., Schoenwolf G.C. (1993): Primitive-streak origin of the cardiovascular system in avian embryos. Dev Biol 159:706–719.

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Porrero J.A., Godin I.E., Dieterlen-Lièvre F. (1995): Potential intraembryonic hemogenic sites at pre-liver stages in the mouse. Anat Embryol 192:425–435.

    Article  PubMed  CAS  Google Scholar 

  • Hirakow R., Hiruma T. (1981): Scanning electron microscopy study on the development of primitive blood vessels in the chicken embryos at the early somite-stage. Anat Embryol 163:299–306.

    Article  PubMed  CAS  Google Scholar 

  • Hirakow R., Hiruma T. (1983): TEM-studies on development and canalization of the dorsal aorta in the chicken embryo. Anat Embryol 166:307–315.

    Article  PubMed  CAS  Google Scholar 

  • His W. (1886): Untersuchungen iiber die erste Anlage des Wirbeltierleibes. Leipzig, Germany: Vogel.

    Google Scholar 

  • Houser J.W., Ackerman G.A., Knouff R.A. (1961): Vasculogenesis and erythropoiesis in the living yolk sac of the chicken embryo. Anat Rec 140:29–13.

    Article  PubMed  CAS  Google Scholar 

  • Huang R., Zhi Q., Wilting J., Christ B. (1994): The fate of somitocoele cells in avian embryos. Anat Embryol 190:243–250.

    Article  PubMed  CAS  Google Scholar 

  • Inagaki T., Garcia-Martinez V., Schoenwolf G.C. (1993): Regulative ability of the prospective cardiogenic and vasculogenic areas of the primitive streak during avian gastrulation. Dev Dyn 197:57–68.

    Article  PubMed  CAS  Google Scholar 

  • Jacob M., Christ B., Jacob H.J. (1979): The migration of myogenic stem cells from the somites into the leg region of avian embryos. Anat Embryol 157:291–309.

    Article  PubMed  CAS  Google Scholar 

  • Jordan H.E. (1916): The microscopic structure of the yolk-sac of the pig embryo with special reference to the origin of the erythrocytes. Am J Anat 19:277–299.

    Article  Google Scholar 

  • Jotereau F.V., Le Douarin N.M. (1978): The developmental relationship between osteocytes and osteoclasts: a study using the quail-chick nuclear marker in endochondral ossification. Dev Biol 63:253–265.

    Article  PubMed  CAS  Google Scholar 

  • Labastie M.C. (1989): MB1, a quail leukocyte-endothelium antigen: further characterization of soluble and cell-associated forms. Cell Diff Dev 27:151–162.

    Article  CAS  Google Scholar 

  • Lance-Jones C. (1988): The somitic level of origin of embryonic chick hind limb muscles. Dev Biol 126:394–407.

    Article  PubMed  CAS  Google Scholar 

  • Le Douarin N.M. (1973): A biological cell labelling technique and its use in experimental embryology. Dev Biol 30:217–222.

    Article  PubMed  Google Scholar 

  • Le Douarin N.M., Jotereau F. (1973): Origin and renewal of lymphocytes in avian embryo thymuses. Nature New Biol 246:25–27.

    Google Scholar 

  • Le Lièvre C., Le Douarin N.M. (1975): Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chicken embryos. J Embryol Exp Morphol 34:125–154.

    PubMed  Google Scholar 

  • Leprince D., Gegonne A., Coll J., De Taisne C., Schneeberger A., Lagrou C., Stéhelin D. (1983): A putative second cell-derived oncogene of the avian leukemia virus E26. Nature 306:395–397.

    Article  PubMed  CAS  Google Scholar 

  • Linask K.K., Lash J.W. (1993): Early heart development: dynamics of endocardial cell sorting suggests a common origin with cardiomyocytes. Dev Dyn 196:62–69.

    Article  PubMed  CAS  Google Scholar 

  • Luton D., Sibony O., Oury J.F., Blot P., Dieterlen-Lièvre F., Pardanaud L. (1996): The c-etsl protooncogene is expressed in human trophoblast during the first trimester of pregnancy. Early Hum Dev 47:147–156.

    Article  Google Scholar 

  • Maroulakou I.G., Papas T.S., Green J.E. (1994): Differential expression of ets-1 and ets-2 protooncogenes during murine embryogenesis. Oncogene 9:1551–1565.

    PubMed  CAS  Google Scholar 

  • Metcalf D., Moore M.A.S. (1971): Embryonic aspects of haemopoiesis. In: Haemopoietic cells, Neuberger A, Tatum EL, eds. Amsterdam: North Holland Publ.

    Google Scholar 

  • Mucenski M.L., Main K., Kier A.B., Swerdlow S.H., Schreiner C.M., Miller T.A., Pietryga D.W., Scott W.J., Potter S. (1991): A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65:677–689.

    Article  PubMed  CAS  Google Scholar 

  • Murray P.D.F. (1932): The development in vitro of the blood of the early chicken embryo. Proc RSoc Loniol 111:497–521.

    CAS  Google Scholar 

  • Noden D.M., (1989): Embryonic origins and assembly of embryonic blood vessels. Ann Rev Pul-mon 140:1097–1103.

    CAS  Google Scholar 

  • Noden D.M. (1991): Origins and patterning of avian outflow tract endocardium. Development 111:867–876.

    PubMed  CAS  Google Scholar 

  • Nunn M.F., Seeburg P.M., Moscovici C., Duesberg P. (1983): Tripartite structure of the avian erythroblastosis virus E26. J Mrol 63:398–402.

    Google Scholar 

  • Pardanaud L., Altmann C., Kitos P., Dieterlen-Lièvre F., Buck C. (1987): Vasculogenesis in the early quail blastodisc as studied with a monoclonal antibody recognizing endothelial cells. Development 100:339–349.

    PubMed  CAS  Google Scholar 

  • Pardanaud L., Yassine F., Dieterlen-Lièvre F. (1989): Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny. Development 105:473–485.

    PubMed  CAS  Google Scholar 

  • Pardanaud L., Dieterlen-Lièvre F. (1993a): Emergence of endothelial and hematopoietic cells in the avian embryo. Anat Embryol 187:107–114.

    Article  PubMed  CAS  Google Scholar 

  • Pardanaud L., Dieterlen-Lièvre F. (1993b): Expression of c-etsl in early chicken embryo mesoderm: relationship to the hemangioblastic lineage. Cell Adomm 1:151–160.

    CAS  Google Scholar 

  • Pardanaud L., Dieterlen-Lièvre F. (1995): Does the paraxial mesoderm of the avian embryo have hemangioblastic capacities? Anat Embryol 192:301–308.

    Article  PubMed  CAS  Google Scholar 

  • Pardanaud L., Luton D., Prigent M., Bourcheix L.M., Catala M., Dieterlen-Lièvre F. (1996): Two distinct endothelial lineages in ontogeny, one of them related to hematopoiesis. Development 122:1363–1371.

    PubMed  CAS  Google Scholar 

  • Patan S., Haenni B., Burri P.H. (1993): Evidence for intussusceptive capillary growth in the chicken chorio-allantoic membrane (CAM). Anat Embryol 187:121–130.

    Article  PubMed  CAS  Google Scholar 

  • Péault B., Thiery J.P., Le Douarin N.M. (1983): A surface marker for the hematopoietic and endothelial cell lineages in the quail species defined by a monoclonal antibody. Proc Natl Acad Sci USA 80:2976–2980.

    Article  PubMed  Google Scholar 

  • Péault B., Coltey M., Le Douarin N.M. (1988): Ontogenic emergence of a quail leukocyte/ endothelium cell surface antigen. Cell Diff 23:165–174.

    Article  Google Scholar 

  • Poole T.J., Coffin D. (1989): Vasculogenesis and angiogenesis: two distinct morphogenetic mechanisms establish embryonic vascular pattern. J Exp Zool 251:224–231.

    Article  PubMed  CAS  Google Scholar 

  • Quéva C., Leprince D., Stéhelin D., Vandenbunder B. (1993): p54c-etsl, and p68c-etsl, the two transcription factors encoded by the c-etsl locus, are differentially expressed during development of the chicken embryo. Oncogene 8:2511–2520.

    PubMed  Google Scholar 

  • Reagan F.P. (1915): Vascularization phenomena in fragments of embryonic bodies completely isolated from yolk sac blastoderm. Anat Rec 9:229–241.

    Article  Google Scholar 

  • Risau W., Flamme I. (1995): Vasculogenesis. Annu Rev Cell Dev Biol 11:73–91.

    Article  CAS  Google Scholar 

  • Risau W., Lemmon V. (1988): Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev Biol 125:441–450.

    Article  PubMed  CAS  Google Scholar 

  • Romanoff A. (1960): The Avian Embryo. New York: The Maillan Company.

    Google Scholar 

  • Roncali L., Virgintino D., Coltey P., Bertossi M., Errede M., Ribatti D., Nico B., Mancini L., Sorino S., Riva A. (1996): Morphological aspects of the vascularization in intraventricular neural transplants from embryo to embryo. Anat Embryol 193:191–203.

    Article  PubMed  CAS  Google Scholar 

  • Sabin F. (1917): Origin and development of the primitive vessels of the chick and of the pig. Contrib Embryol 18:62–124.

    Google Scholar 

  • Sabin F. (1920): Studies on the origin of the blood vessels and of chick during the second day of incubation. Control Embryol 9:215–262.

    Google Scholar 

  • Schramm C., Solursh M. (1990): The formation of premuscle masses during chick wing bud development. Anat Embryol 182:235–247.

    Article  PubMed  CAS  Google Scholar 

  • Shalaby F., Rossant J., Yamaguchi T., Gertsenstein M., Breitman M.L., Schuh A.C. (1995): Failure of blood island formation and vasculogenesis in Flk-1 deficient mice. Nature 376:62–66.

    Article  PubMed  CAS  Google Scholar 

  • Solursh M., Drake C., Meier S. (1987): The migration of myogenic cells from the somites at the wing level in avian embryos. Dev Biol 121:389–396.

    Article  PubMed  CAS  Google Scholar 

  • Solter D., Knowles B.B.(1975): Immunosurgery of mouse blastocyst. Proc Natl Acad Sci USA 72:5099–5102.

    Article  PubMed  CAS  Google Scholar 

  • Sugi Y., Markwald R.R. (1996): Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm. Dev Biol 175:66–83.

    Article  PubMed  CAS  Google Scholar 

  • Tavian M., Coulombel L., Luton D., San Clémente H., Dieterlen-Lièvre F., Péault B. (1996): Aorta-associated CD34+ hematopoietic cells in the early human embryo. Blood 87:67–72.

    PubMed  CAS  Google Scholar 

  • Vandenbunder B., Pardanaud L., Jaffredo T., Mirabel M.A., Stéhelin D. (1989): Complementary patterns of expression of c-etsl, c-myb and c-myc in the blood-forming system of the chicken embryo. Development 107:265–274.

    PubMed  CAS  Google Scholar 

  • Vandenbunder B., Quéva C., Desbiéns X., Wernert N., Stéhelin D. (1996): Expression of the transcription factor c-etsl correlates with the occurrence of invasive processes during normal and pathological development. Inv Metast 95:198–209.

    Google Scholar 

  • Wilting J., Brand-Saberi B., Huang R., Zhi Q., Köntges G. (1995): Angiogenic potential of the avian somite. Dev Dyn 202:165–171.

    Article  PubMed  CAS  Google Scholar 

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  1. Institute d’Embryologie Cellulaire et Moleculaire UMRC 9924, College de France, Centre National de la Recherche Scientifique, 49 bis avenue de la Belle Gabrielle, 94736, Nogent-sur-Marne Cedex, France

    Françoise Dieterlen-Lievre & Luc Pardanaud

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  1. Françoise Dieterlen-Lievre
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  2. Luc Pardanaud
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  1. Department of Cell Biology and Anatomy, Medical University of South Carolina, 29425-2204, Charleston, SC, USA

    Charles D. Little  & Vladimir Mironov  & 

  2. Department of Biological Structures, University of Washington School of Medicine, 98195-7420, Seattle, WA, USA

    E. Helene Sage

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© 1996 Birkhäuser

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Dieterlen-Lievre, F., Pardanaud, L. (1996). Ontogeny of the Endothelial Network Analyzed in the Avian Model. In: Little, C.D., Mironov, V., Sage, E.H. (eds) Vascular Morphogenesis: In Vivo, In Vitro, In Mente. Cardiovascular Molecular Morphogenesis. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4156-0_4

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  • DOI: https://doi.org/10.1007/978-1-4612-4156-0_4

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  • Print ISBN: 978-1-4612-8678-3

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