Skip to main content

Introduction: Understanding Blood Vessel Assembly in the Embryo

  • Chapter
Vascular Morphogenesis: In Vivo, In Vitro, In Mente

Part of the book series: Cardiovascular Molecular Morphogenesis ((CARDMM))

  • 80 Accesses

Abstract

As we approach the end of the 1900s we are rediscovering the elegant embryology that flourished at the beginning of the century. Modern developmental biologists are beginning to place earlier embryological studies on a firm cellular and molecular basis. Sophisticated probes for specific molecules have stimulated a renaissance in the use of the light microscope. Fluorescent markers, digital image processing, and intravital labeling methods have had a major affect on understanding vascular morphogenesis. Targeted mutation of genes related to vascular development in mice bring the powerful tools of molecular biology to bear on understanding assembly of the vascular system. Recent progress is so rapid that keeping up with the latest discoveries is difficult.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • DeRuiter, M.C., Poelmann, R.E., VanMunsteren, J.C., Mironov, V., Markwald, R.R., and Gittenberger-de Groot. Embryonic Endothelial Cells Transdifferentiate into Mesenchymal Cells Expressing Smooth Muscle Actins In Vivo and In Vitro. Circ. Res. 80:444–451, 1997.

    PubMed  CAS  Google Scholar 

  • Hungerford, J.E., Owens, G.K., Argraves, W.S., and Little, C.D. Development of the Vessel Wall as Defined by Vascular Smooth Muscle and ECM Markers. Dev. Biol. 178:375, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Hungerford, J.E., Hoeffler, J.R, Bowers, C.W., Dahm, L.M., Falchetto, R., Shabanowitz, J., Hunt, D.E, and Little, C.D. Identification of a Novel Marker for Pirmordial Smooth Muscle and Its Differential Expression Pattern in Contractile Versus Noncontractile Cells. J. Cell Biol. 137:925–937, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Lee, S.H., Hungerford, J.E., Little, C.D., and Iruela-Arispe, M.L. Proliferation and Differentiation of Smooth Muscle Cell Precursors Occurs Simultaneously During Development of the Vessel Wall. In press.

    Google Scholar 

  • Mikawa, T., and Gourdie, R.G. Pericardial Mesoderm Generates a Population of Coronary Smooth Muscle Cells Migrating into the Heart Along with Ingrowth of the Epicardial Organ. Dev. Biol. 174:221–232, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Sato, T.N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W., and Qin, Y. Nature 376(6535):70–74, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Suri, C., Jones, P.F., Patan, S., Bartunkova, S., Maisonpierre, PC., Davis, S., Sato, T.N., and Yancopoulos, G.D. Requisite Role of Angiopoietin-1, A Ligand for the TIE2 Receptor, During Embryonic Angiogenesis. Cell 87:1171–1180, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Topouzis, S., and Majesky, M.W. Smooth Muscle Lineage Diversity in the Chick Embryo. Dev. Biol. 178:430–445, 1996.

    Article  CAS  Google Scholar 

  • Waldo K.L., Kumiski D., and Kirby M.L. Cardiac Neural Crest is Essential for the Persistence Rather than the Formation of an Arch Artery. Dev. Dyn. 205:281–292, 1996.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Birkhäuser

About this chapter

Cite this chapter

Little, C.D. (1996). Introduction: Understanding Blood Vessel Assembly in the Embryo. In: Little, C.D., Mironov, V., Sage, E.H. (eds) Vascular Morphogenesis: In Vivo, In Vitro, In Mente. Cardiovascular Molecular Morphogenesis. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4156-0_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4156-0_1

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-8678-3

  • Online ISBN: 978-1-4612-4156-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics