Abstract
As we approach the end of the 1900s we are rediscovering the elegant embryology that flourished at the beginning of the century. Modern developmental biologists are beginning to place earlier embryological studies on a firm cellular and molecular basis. Sophisticated probes for specific molecules have stimulated a renaissance in the use of the light microscope. Fluorescent markers, digital image processing, and intravital labeling methods have had a major affect on understanding vascular morphogenesis. Targeted mutation of genes related to vascular development in mice bring the powerful tools of molecular biology to bear on understanding assembly of the vascular system. Recent progress is so rapid that keeping up with the latest discoveries is difficult.
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References
DeRuiter, M.C., Poelmann, R.E., VanMunsteren, J.C., Mironov, V., Markwald, R.R., and Gittenberger-de Groot. Embryonic Endothelial Cells Transdifferentiate into Mesenchymal Cells Expressing Smooth Muscle Actins In Vivo and In Vitro. Circ. Res. 80:444–451, 1997.
Hungerford, J.E., Owens, G.K., Argraves, W.S., and Little, C.D. Development of the Vessel Wall as Defined by Vascular Smooth Muscle and ECM Markers. Dev. Biol. 178:375, 1996.
Hungerford, J.E., Hoeffler, J.R, Bowers, C.W., Dahm, L.M., Falchetto, R., Shabanowitz, J., Hunt, D.E, and Little, C.D. Identification of a Novel Marker for Pirmordial Smooth Muscle and Its Differential Expression Pattern in Contractile Versus Noncontractile Cells. J. Cell Biol. 137:925–937, 1997.
Lee, S.H., Hungerford, J.E., Little, C.D., and Iruela-Arispe, M.L. Proliferation and Differentiation of Smooth Muscle Cell Precursors Occurs Simultaneously During Development of the Vessel Wall. In press.
Mikawa, T., and Gourdie, R.G. Pericardial Mesoderm Generates a Population of Coronary Smooth Muscle Cells Migrating into the Heart Along with Ingrowth of the Epicardial Organ. Dev. Biol. 174:221–232, 1996.
Sato, T.N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W., and Qin, Y. Nature 376(6535):70–74, 1995.
Suri, C., Jones, P.F., Patan, S., Bartunkova, S., Maisonpierre, PC., Davis, S., Sato, T.N., and Yancopoulos, G.D. Requisite Role of Angiopoietin-1, A Ligand for the TIE2 Receptor, During Embryonic Angiogenesis. Cell 87:1171–1180, 1996.
Topouzis, S., and Majesky, M.W. Smooth Muscle Lineage Diversity in the Chick Embryo. Dev. Biol. 178:430–445, 1996.
Waldo K.L., Kumiski D., and Kirby M.L. Cardiac Neural Crest is Essential for the Persistence Rather than the Formation of an Arch Artery. Dev. Dyn. 205:281–292, 1996.
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© 1996 Birkhäuser
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Little, C.D. (1996). Introduction: Understanding Blood Vessel Assembly in the Embryo. In: Little, C.D., Mironov, V., Sage, E.H. (eds) Vascular Morphogenesis: In Vivo, In Vitro, In Mente. Cardiovascular Molecular Morphogenesis. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4156-0_1
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DOI: https://doi.org/10.1007/978-1-4612-4156-0_1
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