Synthetic Biodegradable Polymer Scaffolds

  • Gail K. Naughton
  • Ronnda Bartel
  • Jonathan Mansbridge


Over the last several decades, new technologies have enabled the in vitro cultivation of many different human cell types. At the same time, the art and science of medicine has been expanded to include new biopharmaceutical and recombinant genetic therapies. Organ transplantation has become commonplace, limited not by surgical technique but by donor availability. Tissue engineered organs can obviate the torturous waiting and the human tragedy caused by the scarcity of donor organs. Furthermore, tissue engineered organs can be used in testing procedures, reducing or eliminating the need for animal and human subject tests. The first tissue engineered organ, which has progressed from the lab bench to the first accepted patient care, has been skin, the body’s largest organ (Rheinwald, 1989). Tissue engineering offers many benefits to the patient and has the potential of redefining transplantation. Researchers can use standard, well-recognized cell-banking procedures to characterize the human cell source for these tissue products and to safety-test this source for possible contaminants (US FDA; 1993a). Normal human tissues may be more efficacious than animal or synthetic tissues because normal human tissues supply a balanced natural mixture of growth factors and both structural and interactive functional proteins. These tissues can communicate with the body’s own repair mechanisms to stimulate angiogenesis, remodeling, and other steps to restore complete function.


Surfactant Migration Hepatitis Tyrosine Transportation 


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Copyright information

© Birkhäuser Boston 1997

Authors and Affiliations

  • Gail K. Naughton
    • 1
  • Ronnda Bartel
    • 1
  • Jonathan Mansbridge
    • 1
  1. 1.Advanced Tissue Sciences Inc.La JollaUSA

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