Diabetes and Dementia: A Retrospective Neuropathologic Study of Old Diabetics Compared to Non-Diabetic Controls

  • Jean-Pierre Michel
  • Pius Muller
  • Gabriel Gold
  • Willliam Mac Gee
  • Reihnild Mulligan
  • Constantin Bouras
Part of the Advances in Alzheimer Disease Therapy book series (AADT)


Non-insulin-dependent diabetes mellitus (NIDDM) and dementia are both characterized by high prevalence in later life (Muller, 1993). Differences in prevalence of NIDDM according to regions and races are well-known. In an industrialized society, with a predominantly white population, the rate of NIDDM increases linearly starting from 35 years old, reaching 15% at the age of 75 (Wilson et al., 1986) and 20% at the age of 80 (Morley and Perry, 1991). As for Alzheimer’s Disease (AD), it follows an exponential curve starting from the age of 50, reaching 30% for the 85 year-old population (Skoog et al., 1993).


Creatinine Dementia Acetyl Hyperglycemia Hypoglycemia 


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Copyright information

© Birkhäuser Boston 1997

Authors and Affiliations

  • Jean-Pierre Michel
    • 1
  • Pius Muller
    • 1
  • Gabriel Gold
    • 1
  • Willliam Mac Gee
    • 1
  • Reihnild Mulligan
    • 1
  • Constantin Bouras
    • 2
  1. 1.Department of GeriatricsUniversity Hospitals of GenevaThônex-GenevaSwitzerland
  2. 2.Neuropathology Division, Department of PsychiatryUniversity Hospitals of GenevaThônex-GenevaSwitzerland

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