Abstract
The discovery that (β-amyloid (Aβ) has a powerful biological activity in cultured neurons and other cells has greatly stimulated many new lines of investigation. Only a few years ago it was generally thought that Aβ itself was metabolically inert. It is now clear that Aβ places neurons at risk for injury, damages neuronal processes, and is one of the stimuli that initiates cell death by apoptosis. Aβ can also affect signal transduction processes in non-neuronal cells and thereby reprogram the microenvironment of the brain in the course of aging and neurodegenerative diseases.
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© 1997 Birkhäuser Boston
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Cotman, C.W., Cribbs, D.H., Su, J.H. (1997). Apoptosis and Alzheimer’s Disease: A Self-Assembly and the Initiation of Apoptosis by Plasma Membrane Receptor Cross-Linking. In: Becker, R.E., Giacobini, E., Barton, J.M., Brown, M. (eds) Alzheimer Disease. Advances in Alzheimer Disease Therapy. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4116-4_16
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DOI: https://doi.org/10.1007/978-1-4612-4116-4_16
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