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Biological Consequences of Cross-linked Hemoglobin in Animal Models of Surgery and Endotoxemia

  • Chitra Krishnamurti
  • Barbara M. Alving

Abstract

Cross-linked purified human hemoglobin produced by several companies has been administered successfully to multiple individuals in phase I clinical trials and is now undergoing evaluation in phase II studies. Since hemoglobin will be administered in acute care settings to patients who may have limited cardiovascular reserve or who are septic, its potential biologic activities other than the ability to carry oxygen require consideration. Hemoglobin has an affinity for nitric oxide (NO), a gas with multiple physiologic functions, that is orders of magnitude greater than for oxygen. NO has a dominant role as a vasodilator in regulating blood pressure, as well as in inhibiting adhesion and aggregation of platelets and leukocytes (Moncada and Higgs 1993).

Keywords

Nitric Oxide Coronary Blood Flow Soluble Guanylate Cyclase Platelet Deposition Coronary Artery Constriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Boston 1996

Authors and Affiliations

  • Chitra Krishnamurti
  • Barbara M. Alving

There are no affiliations available

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