Abstract
Viruses have long been suggested to play a role, in the pathogenesis of IDDM. However, it is very difficult to demonstrate the pathogenic role of viruses in human IDDM. On the other hand, many diabetogenic viruses have been investigated in animal models in which diabetes was induced by exogenous inoculation of cytopathic viruses. One of the rare exceptions is the NOD mouse, in which diabetes develops spontaneously and retroviruses have been found in pancreatic B-cells. Other examples are the multiple low-dose streptozotocin (STZ)-induced diabetes mouse and the C3H-db/db mouse. In this chapter, we first review the studies in the latter two mouse models, and then describe our results in the NOD mouse.
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© 1996 Birkhäuser Boston
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Hanafusa, T. et al. (1996). Role of retroviruses in the pathogenesis of diabetes with emphasis on the NOD mouse. In: Shafrir, E. (eds) Lessons from Animal Diabetes VI. Rev.Ser.Advs.Research Diab.Animals (Birkhäuser), vol 6. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4112-6_5
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DOI: https://doi.org/10.1007/978-1-4612-4112-6_5
Publisher Name: Birkhäuser Boston
Print ISBN: 978-1-4612-8658-5
Online ISBN: 978-1-4612-4112-6
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