Molecular genetics of insulin-dependent diabetes mellitus: Analysis of congenic strains

  • Hiroshi Ikegami
  • Susumu Makino
  • Toshio Ogihara
Part of the Rev.Ser.Advs.Research Diab.Animals (Birkhäuser) book series (RSARDA, volume 6)


Insulin-dependent diabetes mellitus (IDDM) is caused by autoimmune destruction of insulin-producing B-cells of the pancreas in genetically susceptible individuals. Both in animal models and humans, major genetic susceptibility to IDDM has been mapped to the major histocompatibility complex (MHC). In addition, recent genome screening has mapped non-MHC susceptibility genes to chromosomal segments in the mouse and human genomes. For most loci, however, only chromosomal locations are known, with no information on the responsible genes and their functions.

Key words

insulin-dependent diabetes mellitus IDDM genetics NOD mouse congenic mice major histocompatibility complex MHC autoimmune disease ancestral haplotype 


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Copyright information

© Birkhäuser Boston 1996

Authors and Affiliations

  • Hiroshi Ikegami
    • 1
    • 3
  • Susumu Makino
    • 2
  • Toshio Ogihara
    • 1
  1. 1.Department of Geriatric MedicineOsaka University Medical SchoolOsakaJapan
  2. 2.Aburahi LaboratoriesShionogi & Co. Ltd.OsakaJapan
  3. 3.Department of Geriatric MedicineOsaka University Medical SchoolSuita, Osaka 565Japan

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