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Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity

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Lessons from Animal Diabetes VI

Part of the book series: Rev.Ser.Advs.Research Diab.Animals (Birkhäuser) ((RSARDA,volume 6))

Abstract

Type II diabetes represents the most common form of diabetes in humans and is a major cause of morbidity and mortality.1In any individual patient, the primary metabolic abnormality initiating this disease process remains elusive, in spite of extensive study of the human condition and multiple animal models.2–5 Most of these models share several features with human type II diabetes, including glucose intolerance associated with hyperinsulinemia, insulin resistance, and obesity. We describe here transgenic mice that represent a novel model of early type II diabetes. They share many physiologic characteristics with other rodent models of type II diabetes, but they are not obese. They are not the result of a poorly defined mutation that may cause extensive abnormalities beyond those seen in glucose homeostasis, and they are not the result of surgical or pharmacologic manipulation. The metabolic abnormalities seen in these transgenics result from the introduction of multiple copies of the normal human insulin gene into their genome.

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Author information

Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Sinai Hospital of Baltimore, USA

    Dr. S. Lee Marbán

  2. Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Jesse Roth

  3. Department of Pediatrics, Sinai Hospital of Baltimore, 2401 W. Belvedere Ave., 21215, Baltimore, MD, USA

    Dr. S. Lee Marbán

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  1. Dr. S. Lee Marbán
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  2. Jesse Roth
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Editors and Affiliations

  1. Department of Biochemistry, Hadassah Medical Center, POB 12000, IL 91120, Jerusalem, Israel

    Eleazar Shafrir

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© 1996 Birkhäuser Boston

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Marbán, S.L., Roth, J. (1996). Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity. In: Shafrir, E. (eds) Lessons from Animal Diabetes VI. Rev.Ser.Advs.Research Diab.Animals (Birkhäuser), vol 6. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4112-6_13

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  • DOI: https://doi.org/10.1007/978-1-4612-4112-6_13

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-8658-5

  • Online ISBN: 978-1-4612-4112-6

  • eBook Packages: Springer Book Archive

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