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Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase

  • Chapter
Lessons from Animal Diabetes VI

Part of the book series: Rev.Ser.Advs.Research Diab.Animals (Birkhäuser) ((RSARDA,volume 6))

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Abstract

Diabetes mellitus is caused by a relative or absolute insulin deficiency, and it affects >5% of the world’s population. Diabetic retinopathy is a leading cause of acquired blindness in adults, and diabetic nephropathy is a major cause of morbidity and mortality in diabetes.1,2 In a population study of 973 subjects, diabetic nephropathy was frequently associated with retinopathy.3 Of patients with diabetes, 18% (66 of 365) had proteinuria and 59% of those patients (39 of 66) had diabetic retinopathy. Of patients with proliferative diabetic retinopathy, 40% (19 of 47) had proteinuria. Of patients with preproliferative retinopathy, 16% (20 of 124) had proteinuria.4

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Authors and Affiliations

  1. Otsuka Department of Clinical and Molecular Nutrition, School of Medicine, The University of Tokushima, Tokushima, 770, Japan

    Mitsuo Itakura M.D., Ph.D.,  Setsuko II, Mika Ohta & Takashi Yamaoka

  2. Otsuka Department of Clinical and Molecular Nutrition, School of Medicine, The University of Tokushima, Kuramoto-cho, Tokushima, 770, Japan

    Mitsuo Itakura M.D., Ph.D.

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  1. Mitsuo Itakura M.D., Ph.D.
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  2. Setsuko II
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  3. Mika Ohta
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  4. Takashi Yamaoka
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Editors and Affiliations

  1. Department of Biochemistry, Hadassah Medical Center, POB 12000, IL 91120, Jerusalem, Israel

    Eleazar Shafrir

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© 1996 Birkhäuser Boston

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Itakura, M., Setsuko, Ohta, M., Yamaoka, T. (1996). Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase. In: Shafrir, E. (eds) Lessons from Animal Diabetes VI. Rev.Ser.Advs.Research Diab.Animals (Birkhäuser), vol 6. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4112-6_12

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