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On the Molecular Basis of NMDA Receptor Diversity

  • Chapter
The Ionotropic Glutamate Receptors

Part of the book series: The Receptors ((REC))

Abstract

NMDA receptors are involved in a wide variety of normal and pathological processes in the vertebrate nervous system. NMDA receptors play an important role in long-term potentiation (LTP) and long-term depression (LTD), experience-dependent formation of synaptic connections in development (Artola and Singer, 1994), neuronal differentiation (Komuro and Rakic, 1993), pain modulation (Meller and Gebhart, 1993), oscillatory depolarization patterns for locomotion (Headley and Grillner, 1990; Hochman et al., 1994), baroreceptor and respiratory reflexes, peristalsis in the colon (Cosentino et al., 1995), and other functions in various neuronal systems. Likewise, excessive NMDA receptor activation is thought to be critical to a wide variety of pathological conditions, such as seizure activity and neuronal cell death following ischemia, hypoglycemia, HIV infection, and head trauma (Meldrum and Garthwaite, 1990; Lipton and Rosenberg, 1994).

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  1. Daniel T. Monaghan
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  2. Amy L. Buller
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  3. Vincent J. Andaloro
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Editors and Affiliations

  1. Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE, USA

    Daniel T. Monaghan

  2. National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA

    Robert J. Wenthold

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Monaghan, D.T., Buller, A.L., Andaloro, V.J. (1997). On the Molecular Basis of NMDA Receptor Diversity. In: Monaghan, D.T., Wenthold, R.J. (eds) The Ionotropic Glutamate Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-3962-8_14

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