Molecular Determinants of Natriuretic Peptide Clearance Receptor Function

  • John A. Lewicki
  • Andrew A. Protter
Part of the Contemporary Endocrinology book series (COE, volume 5)


The natriuretic peptides, atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), elicit their hemodynamic, renal, and neuroendocrine actions via a series of specific receptors on target tissues. To date, three natriuretic peptide receptors have been elucidated and characterized in detail. Two of these receptors are membrane-associated guanylyl cyclases, termed GC-A and GC-B. These receptors, which are reviewed in detail Chapters 3,4, and 6–8, mediate many of the direct biological actions of these peptides. The natriuretic peptide clearance (NP-C) receptor comprises the third member of this receptor family. As its name implies, the NP-C receptor is a unique protein that plays a central role in mediating the metabolic clearance of the natriuretic peptides from the circulation. The NP-C receptor thus serves to regulate plasma concentrations of the natriuretic peptides. Recent data also suggest that this receptor may be responsible for some direct actions of the natriuretic peptides, although the physiological significance of these events is unclear.


Natriuretic Peptide Atrial Natriuretic Peptide Atrial Natriuretic Factor Natriuretic Peptide Receptor Clearance Receptor 
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© Humana Press Inc. 1997

Authors and Affiliations

  • John A. Lewicki
  • Andrew A. Protter

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