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Design and Utilization of Natriuretic Peptide Antagonists

  • Chapter
Natriuretic Peptides in Health and Disease

Part of the book series: Contemporary Endocrinology ((COE,volume 5))

Abstract

Natriuretic peptides play an important role in the hormonal regulation of blood pressure and sodium balance (for review, see refs. 1–3). Recently, the actions of these hormones have extended beyond vasodepressor and natriuretic functions to embrace antiproliferative effects and a role in vascular remodeling (3). The naturally occurring members of the natriuretic peptide family include atrial (ANP), brain (BNP), and C-type natriuretic peptide (CNP) (1–3). Their tissue distribution differs substantially. Although the intracellular mechanisms through which natriuretic peptides elicit their diverse biological effects are not known, their biological effects are mediated by binding to specific membrane-associated receptors in the target tissues (4,5).

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  1. Yuzuru Matsuda
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Editors and Affiliations

  1. Department of Physiology, University of North Dakota School of Medicine, Grand Forks, ND, USA

    Willis K. Samson PhD

  2. Department of Medicine and Pharmacology, University of California at Irvine, USA

    Ellis R. Levin MD

  3. Department of Veterans Affairs Medical Center, Long Beach, CA, USA

    Ellis R. Levin MD

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Matsuda, Y. (1997). Design and Utilization of Natriuretic Peptide Antagonists. In: Samson, W.K., Levin, E.R. (eds) Natriuretic Peptides in Health and Disease. Contemporary Endocrinology, vol 5. Humana Press. https://doi.org/10.1007/978-1-4612-3960-4_17

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  • DOI: https://doi.org/10.1007/978-1-4612-3960-4_17

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