Nucleic Acid Amplification Methods for Identifying Cytogenetic Abnormalities

  • Timothy J. O’Leary
Part of the Contemporary Biomedicine book series (CB, volume 13)


The recognition that malignant neoplasms result from one or more genetic aberrations, together with the development of improved methods for identifying these abnormalities, has given rise to a new discipline, typically referred to as “molecular pathology.” The role of molecular methods in routine diagnosis remains ambiguous, however, because there is a stunning array of different molecular methods for identifying “the same” abnormalities, and because the relationships among the results of “molecular” assays, traditional cytogenetics, and classical histology are incompletely defined.


Acute Lymphoblastic Leukemia Follicular Lymphoma Minimal Residual Disease Mantle Cell Lymphoma Synovial Sarcoma 
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© Humana Press Inc. 1997

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  • Timothy J. O’Leary

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