Activity, Chemoaffinity and Competition: Factors in the Formation of the Retinotectal Map

  • Ronald L. Meyer
Part of the Cell and Developmental Biology of the Eye book series (EYE)


For more than forty years, the retinotectal system of lower vertebrates has been used by developmental neurobiologists as a model to study how growing nerve fibers establish ordered neuronal connections in the central nervous system. For the most part, ordered connections has meant the retinotopic order of the optic projection onto contralateral tectum. Much of the early work has been premised on the assumption that the explanation would come down to a single basic principle, the simpler the hypothesis and the more it could explain, the better.


Optic Nerve Optic Fiber Retinal Ganglion Cell Synapse Elimination Ocular Dominance Column 
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  1. Arnett, D.W. 1978. Statistical dependence between neighboring retinal ganglion cells in goldfish. Exp. Brain Res. 32:49–53.PubMedCrossRefGoogle Scholar
  2. Attardi, D.G., and R.W. Sperry. 1963. Preferential selection of central pathways by regenerating optic fibers. Exp. Neurol. 7:46–64.PubMedCrossRefGoogle Scholar
  3. Bonhoeffer, F., and J. Huf. 1985. Position-dependent properties of retinal axons and their growth cones. Nature 315:409–410.PubMedCrossRefGoogle Scholar
  4. Constantine-Paton, M., and M.I. Law. 1978. Eye-specific termination bands in tecta of three-eyed frogs. Science 202:639–641.PubMedCrossRefGoogle Scholar
  5. Cook, J.E., A.J. Pilgrim, and T.J. Horder. 1983. Consequences of misrouting goldfish optic axons. Exp. Neurol. 79:830–844.PubMedCrossRefGoogle Scholar
  6. Cook, J.E., and E.C. Rankin. 1986. Impaired refinement of the regenerated retinotectal projection of the goldfish in stroboscopic light: a quantitative WGA-HRP study. Exp. Brain Res. 63:421–430.PubMedCrossRefGoogle Scholar
  7. Cook, J.E., E.C. Rankin, and H.P. Stevens. 1983. A pattern of optic axons in the normal goldfish tectum consistent with the caudal migration of optic terminals during development. Exp. Brain Res. 52:147–151.PubMedCrossRefGoogle Scholar
  8. Crossland, W.J., W.M. Cownan, L.A. Rogers, and J.P. Kelly. 1974. The specification of the retino-tectal projection in the chick. J. Comp. Neurol. 155:127–164.PubMedCrossRefGoogle Scholar
  9. Fawcett, J.W. 1981. How axons grow down the Xenopus optic nerve. J. Embryol. Exp. Morphol. 65:219–233.PubMedGoogle Scholar
  10. Fawcett, J.W., and R.M. Gaze. 1982. The retinotectal fibre pathways from normal and compound eyes in Xenopus. J. Embryol. Exp. Morph. 72:19–37.PubMedGoogle Scholar
  11. Fraser, S.E. 1980. A differential adhesion approach to the patterning of nerve connections. Dev. Biol. 79:453–464.Google Scholar
  12. Freeman, J.A., J.T. Schmidt, and R.E. Oswald. 1980. Effect of a-bungarotoxin on retinotectal synaptic transmission in the goldfish and the toad. Neurosci. 5:929–942.CrossRefGoogle Scholar
  13. Frost, D.O., and G.E. Schneider. 1979. Plasticity of retinofugal projections after partial lesions of the retina in newborn Syrian hamster. J. Comp. Neurol. 185:517–568.PubMedCrossRefGoogle Scholar
  14. Fujisawa, H.. 1981. Retinotopic analysis of fiber pathways in the regenerating retinotectal system of the adult newt Cynops Pyrrhogaster. Brain Res. 206:27–37.PubMedCrossRefGoogle Scholar
  15. Gaze, R.M., and R.A. Hope. 1983. The visuotectal projection following translocation of grafts within an optic tectum in the goldfish. J. Physiol. 344: 257–275.PubMedGoogle Scholar
  16. Gaze, R.M., M.J. Keating, and S.H. Chung. 1974. The evolution of the retinotectal map during development in Xenopus. Proc. R. Soc. Lond. B. 185:301–330.PubMedCrossRefGoogle Scholar
  17. Gaze, R.M., and S.C. Sharma. 1970. Axial differences in the reinnervation of the goldfish optic tectumby regeneration optic nerve fibers. Exp. Brain Res. 10: 171–181.PubMedCrossRefGoogle Scholar
  18. Hayes, W.P., and R.L. Meyer. 1985. Clustered synapse formation by early regenerating retinotectal fibers precedes the sublaminar redeployment of retinal connections. Soc. Neurosci. 11:977.Google Scholar
  19. Hayes, W.P., and R.L. Meyer. 1986. Retinotectal synapse numbers are regulated by an activity- independent and target-dependent mechanism in goldfish. Soc. Neurosci. 12:436.Google Scholar
  20. Hayes, W.P., and R.L. Meyer. 1988. Retinotopically inappropriate synapses of subnormal density formed by surgically misdirected optic fibers in goldfish tectum. Dev. Brain Res. 38:304–312.CrossRefGoogle Scholar
  21. Horder, T.J., and K.A.C. Martin. 1978. Morphogenetics as an alternative to chemospecificity in the formation of nerve connections. In A.S.G. Curtis (ed): Cell-cell recognition. Cambridge: Cambridge Univ. Press, pp. 275–358Google Scholar
  22. Hubel, D.H., T.N. Wiesel, and S. LeVay. 1977. Plasticity of ocular dominance columns in monkey striate cortex. Phil. Trans. Roy. Soc. London B. 278:377–409.PubMedCrossRefGoogle Scholar
  23. Ide, C.F., S.E. Fraser, and R.L. Meyer. 1983. Eye dominance columns from an isogenic double-nasal frog eye. Science 221:293–295.PubMedCrossRefGoogle Scholar
  24. Kageyama, G.H., and R.L. Meyer. 1985. Histochemical localization of cytochrome oxidase in the normal and denervated goldfish optic tectum: a combined golgi-cytochrome oxidase study. Soc. Neurosci. 11:236.Google Scholar
  25. Kageyama, G.H., and R.L. Meyer. 1987. Immunohistochemical localization of gaba, choline acetyltransferase, glutamate and aspartate in the visual systems of goldfish and mice. Soc. Neurosci. 13:860.Google Scholar
  26. Kageyama, G.H., and R.L. Meyer. 1988. Histochemical localization of cytochrome oxidase in the normal retina and optic tectum of goldfish: A combined C.O. — HRP study. J. Comp. Neurol.:.Google Scholar
  27. LeVay, S., M.P. Stryker, and C.J. Shatz. 1978. Ocular dominance columns and their development in layer IV of the cat’s visual cortex. J. Comp. Neurol. 179:223–244.PubMedCrossRefGoogle Scholar
  28. Levine, R.L., and M. Jacobson. 1975. Discontinuous mapping of retina onto tectum innervated by both eyes. Brain Res. 98:172–176.PubMedCrossRefGoogle Scholar
  29. Marotte, L.R.. 1983. Increase in synaptic sites in goldfish tectum after partial tectal ablation. Neurosci. Lett. 36:261.PubMedCrossRefGoogle Scholar
  30. Meek, J.. 1983. Functional anatomy of the tectum mesencephali of the goldfish: An explorative analysis of the functional implication of the laminor structure organization of the tectum. Brain Res. Rev. 6:247–297.CrossRefGoogle Scholar
  31. Meyer. 1983. Tetrodotoxin inhibits the formation of refined retinotopography in goldfish. Brain Res. 6:293–298.CrossRefGoogle Scholar
  32. Meyer, R.L.. 1977. Eye-in-water electrophysiological mapping of goldfish with and without tectal lesions. Exp. Neurol. 56:23–41.PubMedCrossRefGoogle Scholar
  33. Meyer, R.L.. 1978a. Deflection of selected optic fibers into a denervated tectum in goldfish. Brain Res. 155:213–227.PubMedCrossRefGoogle Scholar
  34. Meyer, R.L.. 1978b. Evidence from thymidine labelling for continuing growth of retina and tectum in juvenile goldfish. Exp. Neurol. 59:99–111.PubMedCrossRefGoogle Scholar
  35. Meyer, R.L.. 1979a. “Extra” optic fibers exclude normal fibers from tectal regions in goldfish. J. Comp. Neurol. 183:883–902.PubMedCrossRefGoogle Scholar
  36. Meyer, R.L.. 1979b. Retinotectal profjection in goldfish to an inappropriate region with a reversal in polarity. Science 205:819–821.PubMedCrossRefGoogle Scholar
  37. Meyer, R.L.. 1980. Mapping the normal and regenerating retinotectal projection of goldfish with autoradiographic methods. J. Compl Neurol. 189:273–289.CrossRefGoogle Scholar
  38. Meyer, R.L.. 1981. “Ocular dominance” columns in goldfish, ontogeny and effect of visual environment. Soc. Neurosci. 7:405.Google Scholar
  39. Meyer, R.L.. 1982a. Ordering of retinotectal connections: a multivariate operational analysis. Curr. Top. Dev. Biol. 17:101–145.PubMedCrossRefGoogle Scholar
  40. Meyer, R.L.. 1982b. Tetrodotoxin blocks the formation of ocular dominance columns in goldfish. Science 218:589–591.PubMedCrossRefGoogle Scholar
  41. Meyer, R.L.. 1983. The growth and formation of ocular dominance columns by deflected optic fibers in goldfish. Dev. Brain Res. 6:279–291.CrossRefGoogle Scholar
  42. Meyer, R.L.. 1984. Target selection by surgically misdirected optic fibers in the tectum of goldfish. J. Neurosci. 4:234–250.PubMedGoogle Scholar
  43. Meyer, R.L.. 1987a. Tests for relabelling the goldfish tectum by optic fibers. Dev. Brain Res. 31: 312–318.CrossRefGoogle Scholar
  44. Meyer, R.L.. 1987b. Intratectal targeting by optic fibers in goldfish under impulse blockade. Dev. Brain Res. 37:115–124.CrossRefGoogle Scholar
  45. Meyer, R.L. and D.L. Brink. 1988. Locally correlated activity in the goldfish tectum in the absence of optic innervation. Dev. Brain Res. in press.Google Scholar
  46. Meyer, R.L., K. Sakurai, and E. Schauwecker. 1985. Topography of regenerating optic fibers in goldfish traced with local wheat germ injections into retina: Evidence for discontinuous microtopography in the retinotectal projection. J. Comp. Neurol. 239:27–43.PubMedCrossRefGoogle Scholar
  47. Meyer, R.L., and L.L. Wolcott. 1987. Compression and expansion without impulse activity in the retinotectal projection of goldfish. J. Neurobiol. 18:549–567.PubMedCrossRefGoogle Scholar
  48. Murray, M., and M.A. Edwards. 1982. A quantitative study of the reinnervation of the goldfish optic tectum following optic nerve crush. J. Comp. Neurol. 209: 363–373.PubMedCrossRefGoogle Scholar
  49. Murray, M., S. Sharma, and M.A. Edwards. 1982. Target regulation of synaptic number in the compressed retinotectalprojection of goldfish. J. Comp. Neurol. 209:374–385.PubMedCrossRefGoogle Scholar
  50. Olson, M.D., and R.L. Meyer. 1987. Refinement of the goldfish retinotectal projection in the absence of activity and in the dark. Soc. Neurosci. 13:1418.Google Scholar
  51. Rakic, P.. 1977. Prenatal development of the visual system in rhesus monkey. Phil. Trans. R. Soc. Lond. B. 278:245–260.CrossRefGoogle Scholar
  52. Reh, T., and M. Constantine-Paton. 1985. Eye-specific segregation requires neural activity in three-eyed Rana pipiens. J. Neurosci. 5:1132–1143.PubMedGoogle Scholar
  53. Schmidt, J.T., C.M. Cicerone, and S.S. Easter. 1978. Expansion of the half retinal projection to the tectum in goldfish: an electrophysiological and anatomical study. J. Comp. Neurol. 177:257–278.CrossRefGoogle Scholar
  54. Schmidt, J.T., and D.L. Edwards. 1983. Activity sharpens the map during the regeneration of the retinotectal projection in goldfish. Brain Res. 269:29–39.PubMedCrossRefGoogle Scholar
  55. Schmidt, J.T., and L.E. Eisele. 1985. Stroboscopic illumination and dark-rearing block the sharpening of the regenerated retinotectal map in goldfish. Neuroscience 14:535–546.PubMedCrossRefGoogle Scholar
  56. Schmidt, J.T., and J.A. Freeman. 1980. Electrophysiological evidence that retinotectal synaptic transmission in the goldfish is nicotinic cholinergic. Brain Res. 187:129–142.PubMedCrossRefGoogle Scholar
  57. Scholes, J.H.. 1979. Nerve fiber topography in the retinal projection to the tectum. Nature 278:620–624.PubMedCrossRefGoogle Scholar
  58. Shatz, C.J., and M.P. Stryker. 1978. Ocular dominance in layer IV of the cat’s visual cortex and the effects of monocular deprivation. J. Physiol. 281:267–283.PubMedGoogle Scholar
  59. Sperry, R.W.. 1944. Optic nerve regeneration with return of vision in anurans. J. Neurophysiol. 7:57–69.Google Scholar
  60. Sperry, R.W.. 1945. Restoration of vision after crossing of optic nerves and after contralateral transposition of the eye. J. Neurophysiol. 8:15–28.Google Scholar
  61. Sperry, R.W.. 1963. Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc. Nat. Acad. Sci. U.S.A. 50:703–710.CrossRefGoogle Scholar
  62. Stent, G.S.. 1973. A physiological mechanism for Hebb’s postulate of learning. Proc. Nat. Acad. Sci. U.S.A. 70:997–1001.CrossRefGoogle Scholar
  63. Straznicky, C., R.M. Gaze, and T.J. Horder. 1979. Selection of appropriate medial branch of the optic tract by fibres of ventral retinal origin during development and in regeneration: An autoradiographic study in Xenopus. J. Embryol. Exp. Morph. 50:253–267.PubMedGoogle Scholar
  64. Stryker, M.P., and W.A. Harris. 1986. Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex. J. Neurosci. 6:2117–2133.PubMedGoogle Scholar
  65. Teyler, T.J., D. Lewis, and V.E. Shashoua. 1981. Neurophysiological and biochemical properties of the goldfish optictectum maintained in vitro. Brain Res. Bull. 7:45–56.PubMedCrossRefGoogle Scholar
  66. Udin, S.B., and R.M. Gaze. 1983. Expansion and retinotopic order in the goldfish retinotectal map after large retinal lesions. Exp. Brain Res. 50:347–352.PubMedCrossRefGoogle Scholar
  67. Wong-Riley, M., and D.A. Riley. 1983. The effect of impulse blockage on cytochrome oxidase activity in the cat visual system. Brain Res. 261:185–193.PubMedCrossRefGoogle Scholar
  68. Yoon, M.. 1973. Retention of the original topographic polarity by the 1800 rotated tectal reimplant in young goldfish. J. Physiol. 233:575–588.PubMedGoogle Scholar
  69. Yoon, M.. 1976. Progress of topographic regulation of the visual projection in the halved optic tectum of adult goldfish. J. Physiol. 257:621–643.PubMedGoogle Scholar

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© Springer-Verlag New York Inc. 1988

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  • Ronald L. Meyer

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