Activity, Chemoaffinity and Competition: Factors in the Formation of the Retinotectal Map
For more than forty years, the retinotectal system of lower vertebrates has been used by developmental neurobiologists as a model to study how growing nerve fibers establish ordered neuronal connections in the central nervous system. For the most part, ordered connections has meant the retinotopic order of the optic projection onto contralateral tectum. Much of the early work has been premised on the assumption that the explanation would come down to a single basic principle, the simpler the hypothesis and the more it could explain, the better.
KeywordsOptic Nerve Optic Fiber Retinal Ganglion Cell Synapse Elimination Ocular Dominance Column
Unable to display preview. Download preview PDF.
- Fraser, S.E. 1980. A differential adhesion approach to the patterning of nerve connections. Dev. Biol. 79:453–464.Google Scholar
- Hayes, W.P., and R.L. Meyer. 1985. Clustered synapse formation by early regenerating retinotectal fibers precedes the sublaminar redeployment of retinal connections. Soc. Neurosci. 11:977.Google Scholar
- Hayes, W.P., and R.L. Meyer. 1986. Retinotectal synapse numbers are regulated by an activity- independent and target-dependent mechanism in goldfish. Soc. Neurosci. 12:436.Google Scholar
- Horder, T.J., and K.A.C. Martin. 1978. Morphogenetics as an alternative to chemospecificity in the formation of nerve connections. In A.S.G. Curtis (ed): Cell-cell recognition. Cambridge: Cambridge Univ. Press, pp. 275–358Google Scholar
- Kageyama, G.H., and R.L. Meyer. 1985. Histochemical localization of cytochrome oxidase in the normal and denervated goldfish optic tectum: a combined golgi-cytochrome oxidase study. Soc. Neurosci. 11:236.Google Scholar
- Kageyama, G.H., and R.L. Meyer. 1987. Immunohistochemical localization of gaba, choline acetyltransferase, glutamate and aspartate in the visual systems of goldfish and mice. Soc. Neurosci. 13:860.Google Scholar
- Kageyama, G.H., and R.L. Meyer. 1988. Histochemical localization of cytochrome oxidase in the normal retina and optic tectum of goldfish: A combined C.O. — HRP study. J. Comp. Neurol.:.Google Scholar
- Meyer, R.L.. 1981. “Ocular dominance” columns in goldfish, ontogeny and effect of visual environment. Soc. Neurosci. 7:405.Google Scholar
- Meyer, R.L. and D.L. Brink. 1988. Locally correlated activity in the goldfish tectum in the absence of optic innervation. Dev. Brain Res. in press.Google Scholar
- Olson, M.D., and R.L. Meyer. 1987. Refinement of the goldfish retinotectal projection in the absence of activity and in the dark. Soc. Neurosci. 13:1418.Google Scholar
- Sperry, R.W.. 1944. Optic nerve regeneration with return of vision in anurans. J. Neurophysiol. 7:57–69.Google Scholar
- Sperry, R.W.. 1945. Restoration of vision after crossing of optic nerves and after contralateral transposition of the eye. J. Neurophysiol. 8:15–28.Google Scholar