Tolerance of Perfluorocarbons, Fluorosilicone, and Silicone Liquids in the Vitreous

  • Mark E. Hammer
  • Deborah F. Rinder
  • E. Lynn Hicks
  • Chang-Hsu Yang
  • Carlton A. Hornung


Silicone oil (polydimethylsiloxane) has been under investigation for over 20 years as a retinal tamponade in the treatment of retinal detachments. The use of intraocular air and sulfur hexafluoride gas has become routine for the tamponade of retinal breaks after vitrectomy while chorioretinal scarring from cryopexy, diathermy, or photothermal treatment gains adequate mechanical strength. Improvement in the rate of success for retinal reattachment has been reported in cases in which the longer lasting perfluorocarbon gases are used.1 The impression that longer retinal tamponade gives a higher reattachment rate for complex retinal detachments has lead to renewed interest in silicone oil. Clinical studies with silicone oil emphasize either favorable results2–4 or complications.5 Interpretation of the histopathology in these eyes has also varied. Some studies have shown that silicone oil is not toxic,6 while others reported retinal toxicity7 and degeneration of ganglion cells.8


Silicone Liquid Retinal Break Mature Cataract Perfluorocarbon Liquid Vitreous Substitute 
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  1. 1.
    Lincoff A, Lincoff H, Jokobiec F, et al. Perfluoro-n-butane. A gas for maximum duration retinal tamponade. Arch Ophthal 1983;101:460–462.PubMedGoogle Scholar
  2. 2.
    Cibis PA, Becker B, Okun E, et al. The use of silicone oil in retinal detachment surgery. Arch Ophthalmol 1962;68:590–599.PubMedGoogle Scholar
  3. 3.
    Gonvers M. Temporary use of intraocular silicone oil in the treatment of detachment with massive preretinal proliferation. Ophthalmologica 1982;184:210–218.PubMedCrossRefGoogle Scholar
  4. 4.
    Živojnović R, Mertens DAE, Peperkamp E. Das Flussige silikon inder Amotiochirurgie (II) Bericht uber 280 Falleweitere Entwicklung der Technik. Klin Mbl Augenheilk 1982;181:444–452.PubMedCrossRefGoogle Scholar
  5. 5.
    Watzke RC. Silicone retinopoesis for retinal detachment. A long term clinical evaluation. Arch Ophthal 1977;77:185–196.Google Scholar
  6. 6.
    Ober RR, Blands JD, Ogden JE, et al. Experimental retinal tolerance to liquid silicone. Retina 1983;3:77–84.PubMedCrossRefGoogle Scholar
  7. 7.
    Mukai M, Lee PF, Schepens CI. Intravitreous injection of silicone: an experiment study. II. Histochemistry and electron microscopy. Ann Ophthal 1972;4:273–287.PubMedGoogle Scholar
  8. 8.
    Mukai M, Lee PF, Oguni M, et al. A long term evaluation of silicone retinopathy in monkeys. Can J Ophthalmol 1975;10:391–401.PubMedGoogle Scholar
  9. 9.
    Miyamoto K, Refojo MR, Tolentino FI, et al. Fluorosilicone oils as experimental vitreous substitutes. Invest Ophthalmol Vis Sci 1985;26(suppl):34.Google Scholar
  10. 10.
    Wilkinson AW, Farber ME, Zimmerman NJ. Anterior chamber toxicity for perfluorotri-n-propylamine: a vitreous substitute. Invest Ophthalmol Vis Sci 1985;25(suppl):34.Google Scholar
  11. 11.
    Miyamoto K, Refojo MR, Tolentino FI, et al. Perfluoroether liquid as a long term vitreous substitute. An experimental study. Retina 1984;4:264–268.CrossRefGoogle Scholar
  12. 12.
    Thresher R, Ehrenberg M, Chandler D, et al. Vitreous compression: an experimental alternative to vitrectomy. Invest Ophthalmol Vis Sci 1983;24(suppl):242.Google Scholar
  13. 13.
    Ray AA (ed.). SAS User’s Guide: statistics. 1982 edition, Cary, North Carolina, USAA, SAS Institute Inc., 1982, pp 1–222.Google Scholar
  14. 14.
    LoCasicio JA, Hammer M, Rinder D, et al. Effect of selected liquid perfluorochemicals compared to high and low viscosity silicone oil on corneal stroma and endothelium. Invest Ophthalmol Vis Sci 1985;26(suppl):145.Google Scholar
  15. 15.
    Kampik A, Gabel V-P, Spiegel D. Intraokulare Tamponade mit hochviskosen Silikonal bei massiver proliferativer Vitro-Retinopathie. Klin Mbl Augenheilk 1984;1985:368–370.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Mark E. Hammer
  • Deborah F. Rinder
  • E. Lynn Hicks
  • Chang-Hsu Yang
  • Carlton A. Hornung

There are no affiliations available

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