Haemophilus influenzae Infections
Since its original description by Pfeiffer in 1892 in association with respiratory disease, Haemophilus influenzae has been found in a number of clinical syndromes involving several organ systems. Encapsulated strains were recognized by Pittman (1931) in association with invasive disease and six serotypes (a-f) have been described based on capsular antigen. Over 95% of all invasive disease has been associated with strains producing the serotype b capsule, although invasive disease due to other capsular serotypes and nonencapsulated strains has been described. Nonencapsulated strains are largely responsible for local mucosal disease of the respiratory tract and contiguous structures such as otitis media, conjunctivitis, genitourinary tract infection, and invasive neonatal disease acquired from the maternal genital tract. Infections due to H. influenzae are perhaps the most important bacterial infections of childhood and are associated with significant morbidity and mortality.
KeywordsOtitis Medium Bacterial Meningitis Septic Arthritis Invasive Disease Latex Agglutination
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