Experimental Studies of Congenital Malformations in Diabetic Pregnancy

  • Ulf J. Eriksson
Part of the Endocrinology and Metabolism book series (EAM, volume 2)


Despite considerable progress in the clinical management of diabetic pregnancy, the incidence of congenital malformations is approximately three times greater in infants of diabetic mothers than in the offspring of nondiabetic women (1–6). Congenital malformations observed in the infants of diabetic mothers more often tend to be multiple, more severe, and lethal than those seen in infants of nondiabetic mothers (3,5,6). The incidence of congenital malformations has not changed over the last few decades, whereas that of almost all other complications has decreased (4). The relative importance of malformations has therefore increased, and they are presently the most common cause of perinatal death among infants of diabetic mothers (5).


Congenital Malformation Diabetic Mother Maternal Diabetes Fetal Malformation Diabetic Pregnancy 
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  1. 1.
    Duncan JM (1982) On puerperal diabetes. Trans Obstet Soc London 24: 256 – 85.Google Scholar
  2. 2.
    Mølsted-Pedersen L, Tygstrup I, Pedersen J (1964) Congenital malformations in newborn infants of diabetic women. Correlation with maternal diabetic vascular complications. Lancet 1: 1124 – 6.Google Scholar
  3. 3.
    Pedersen J (1977) The pregnant diabetic and her newborn ed 2. Copenhagen, Munksgaard, pp 1 – 280.Google Scholar
  4. 4.
    Freinkel N (1982) Of pregnancy and progeny. Banting Lecture. Diabetes 29: 1023 – 35.Google Scholar
  5. 5.
    Mills JL (1982) Malformations in infants of diabetic mothers. Teratology 25: 385 – 94.PubMedGoogle Scholar
  6. 6.
    Kucera J (1971) Rate and type of congenital anomalies among offspring of diabetic women. J Reprod Med 7: 61 – 70.Google Scholar
  7. 7.
    Pedersen JF, M0lsted-Pedersen L (1982) Early growth delay predisposes the fetus in diabetic pregnancy to congenital malformation. Lancet 1: 737.PubMedGoogle Scholar
  8. 8.
    Eriksson UJ, Lewis NJ, Freinkel N (1984) Growth retardation during early organogenesis in embryos of experimentally diabetic rats. Diabetes 33: 281 – 4.PubMedGoogle Scholar
  9. 9.
    Spiers PS (1982) Does growth retardation predispose the fetus to congenital malformation? Lancet 1: 312 – 4.PubMedGoogle Scholar
  10. 10.
    Tchobroutsky C, Breart GL, Rambaud DC, Henrion R (1985) Correlation between fetal defects and early growth delay observed by ultrasound. Lancet 1: 706 – 7.PubMedGoogle Scholar
  11. 11.
    Ross OA, Spector S (1952) Production of congenital abnormalities in mice by alloxan. Am J Dis Child 84: 647 – 8.Google Scholar
  12. 12.
    Bartelheimer H, Kloos K (1952) Die Auswirkung des experimentellen Diabetes auf Gravidität und Nachkommenschaft. Z Gesamte Exp Med 119: 246 – 65.PubMedGoogle Scholar
  13. 13.
    Kreshover SJ, Clough W, Bear DM (1953) Prenatal influences on tooth development. I. Alloxan diabetes in rats. J Dent Res 32: 246 – 61.PubMedGoogle Scholar
  14. 14.
    Fujimoto S, Sumi T, Kuzukawa S, Tonoike H, Miyoshi T, Nakamura S (1958) The genesis of experimental anomalies—fetal anomalies in reference to experimental diabetes in rabbit. J Osaka City Med Ctr 7: 62–66 (in Japanese).Google Scholar
  15. 15.
    Koskenoja M (1961) Alloxan diabetes in the pregnant mouse. Acta Ophthalmol [Suppl] (Copenh) 68: 1 – 92.Google Scholar
  16. 16.
    Watanabe G, Ingalls TH (1963) Congenital malformation in the offspring of alloxan-diabetic mice. Diabetes 12: 66 – 72.PubMedGoogle Scholar
  17. 17.
    Mohr U, Althoff J, Wrba H (1964) Morphologische Veranderungen der Rat- tenplazenta beim Alloxandiabetes. Naturwissenschaften 51: 440.Google Scholar
  18. 18.
    Barashnev YI (1965) Malformation of fetal brain resulting from alloxan diabetes in mother. Fed Proc 24: 382 – 86.Google Scholar
  19. 19.
    Endo A (1966) Teratogenesis in diabetic mice treated with alloxan prior to conception. Arch Environ Health 12: 492 – 500.PubMedGoogle Scholar
  20. 20.
    Horii K, Watanabe G, Ingalls TH (1966) Experimental diabetes in pregnant mice: prevention of congenital malformations in offspring by insulin. Diabetes 15: 194 – 204.PubMedGoogle Scholar
  21. 21.
    Takano K, Nishimura H (1967) Congenital malformations induced by alloxan diabetes in mice and rats. Anat Rec 158: 303 – 12.PubMedGoogle Scholar
  22. 22.
    Endo A, Ingalls TH (1968) Chromosomal anomalies in embryos of diabetic mice. Arch Environ Health 16: 316 – 25.PubMedGoogle Scholar
  23. 23.
    Ichikari I (1970) Experimental studies concerning the prevention of diabetic embryopathy. Prevention of congenital malformations in alloxan-diabetic pregnant mice by the oral application of tolbutamide. Congenital Anomalies 10: 29–40 (in Japanese).Google Scholar
  24. 24.
    Yamamoto M, Endo A, Watanabe G, Ingalls TH (1971) Chromosomal aneu- ploidies and polyploidies in embryos of diabetic mice. Arch Environ Health 22: 468 – 75.PubMedGoogle Scholar
  25. 25.
    Prager R, Abramovici A, Liban E, Laron Z (1974) Histopathological changes in the placenta of streptozotocin induced diabetic rats. Diabetologia 10: 89 – 91.PubMedGoogle Scholar
  26. 26.
    Emmrich P, Caffier P (1976) Plazentare Veränderungen bei Ratten mit Strep- tozotocin-diabetes. Endokrinologie 67: 79 – 84.PubMedGoogle Scholar
  27. 27.
    Liban E. Abramovici A, Sporn J, Prager R, Laron Z (1976) Morphological and biochemical changes in the placenta of streptozotocin-induced diabetic rats. Harefuah 90: 508–13 (in Hebrew, English abstract, pp 546–47).Google Scholar
  28. 28.
    Deuchar EM (1977) Embryonic malformations in rats, resulting from maternal diabetes: preliminary observations. J Embryol Exp Morphol 41: 93 – 9.PubMedGoogle Scholar
  29. 29.
    Brownscheidle CM, Davies DL (1981) Diabetes in pregnancy: a preliminary study of the pancreas, placenta and malformations in the BB Wistar rat. Placenta 33 [Suppl]: 203 – 16.Google Scholar
  30. 30.
    Baker L, Egler JM, Klein SM, Goldman AS (1981) Meticulous control of diabetes during organogenesis prevents congenital lumbosacral defects in rats. Diabetes 30: 955 – 59.PubMedGoogle Scholar
  31. 31.
    Eriksson UJ, Dahlström E, Larsson KS, Hellerström C (1982) Increased incidence of congenital malformations in the offspring of diabetic rats and their prevention by maternal insulin therapy. Diabetes 31: 1 – 6.PubMedGoogle Scholar
  32. 32.
    Brownscheidle CM, Wootten, V, Mathieu MH, Davis DL, Hofman IA (1983) The effects of maternal diabetes on fetal maturation and neonatal health. Metabolism 32 [Suppl]: 148 – 55.PubMedGoogle Scholar
  33. 33.
    Eriksson UJ, Dahlström E, Hellerström C (1983) Diabetes in pregnancy: Skeletal malformations in the offspring of diabetic rats after intermittent withdrawal of insulin in early gestation. Diabetes 31: 1141 – 45.Google Scholar
  34. 34.
    Funaki K, Mikano K (1983) Developmental-stage-dependent teratogenic effects of maternal spontaneous diabetes in the Chinese hamster. Diabetes 32: 637 – 43.PubMedGoogle Scholar
  35. 35.
    Eriksson UJ (1984) Diabetes in pregnancy: Fetal growth retardation, congenital malformations and feto-maternal concentrations of zinc, copper and manganese in the rat. J Nutr 114: 477 – 86.PubMedGoogle Scholar
  36. 36.
    Ornoy A, Merin B, Zusman I, Granat M, Barash V, Shafris E (1984) Placental and skeletal changes in fetuses of streptozotocin-diabetic rats. In: Shafrir E, Renold AE (eds) Lessons from Animal Diabetes. John Libbey & Co. Ltd, London, pp 775 – 81.Google Scholar
  37. 37.
    Eriksson UJ, Dahlström VE, Lithell HO (1986) Diabetes in pregnancy: influence of genetic background and maternal diabetic state on the incidence of skeletal malformations in the fetal rat. Acta Endocrinol (Copenh) 112 (Suppl 277): 66 – 73Google Scholar
  38. 38.
    Mandrey J (1940) Development of cataract in the embryonic lens of the albino rat. Anat Rec 76 [Suppl 2]: 92.Google Scholar
  39. 39.
    Bannon SL, Higginbottom RM, McConnel JM, Kaan HW (1945) Development of galactose cataract in the albino rat embryo. Arch Ophthalmol 33: 224 - 28.Google Scholar
  40. 40.
    Segal S, Bernstein H (1963) Observations on cataract formation in the newborn offspring of rats fed a high-galactose diet. J Pediatr 62: 363 – 70.PubMedGoogle Scholar
  41. 41.
    Clavert A, Wolff-Quenot MJ, Buck P (1972) Etude de Taction embryopat- hique du glucose en injection intraamniotique. C R Soc Biol (Paris) 166: 1789 – 92.Google Scholar
  42. 42.
    Clavert A, Wolff-Quenot MJ. (1973) Etude du mode d’action embryopathique du glucose en injection dans le liquide ovulaire du Lapin. C R Soc Biol (Paris) 167: 1452 – 4.Google Scholar
  43. 43.
    Hughes AF, Freeman FB, Fadem T (1974) The teratogenic effects of sugars on the chick embryo. J Embryol Exp Morphol 32: 661 – 74.PubMedGoogle Scholar
  44. 44.
    Ornoy A, Cohen AM (1980) Teratogenic effects of sucrose diet in diabetic and non-diabetic rats. Isr J Med Sci 16: 789 – 91.PubMedGoogle Scholar
  45. 45.
    Buchanan TA, Freinkel N, Lewis NJ, et al (1985) Fuel-mediated teratogenesis.Use of D-mannose to modify organogenesis in the rat embryo in vivo. J Clin Invest 75:1927–34.PubMedCentralPubMedGoogle Scholar
  46. 46.
    Cockroft DL, Coppola PT (1977) Teratogenic effects of excess glucose on head-fold rat embryos in culture. Teratology 16: 141 – 6.PubMedGoogle Scholar
  47. 47.
    Deuchar E (1979) Culture in vitroas a means of analysing the effect of maternal diabetes on embryonic development in rats. In: Elliott K, O’Connor M (eds) Pregnancy metabolism, diabetes and the fetus. CIBA Foundation Series 63, Excerpta Medica, Amsterdam, pp 181 – 97.Google Scholar
  48. 48.
    Sadler TW (1980) Effects of maternal diabetes on early embryogenesis. I. The teratogenic potential of diabetic serum. Teratology 21: 339 – 47.PubMedGoogle Scholar
  49. 49.
    Sadler TW (1980) Effects of maternal diabetes on early embryogenesis. II. Hyperglycemia-induced exencephaly. Teratology 21: 349 – 56.PubMedGoogle Scholar
  50. 50.
    Horton WE Jr, Sadler TW (1983) Effects of maternal diabetes on early embryogenesis. Alternations in morphogenesis produced by the ketone body, P-hydroxybutyrate. Diabetes 32: 610 – 6.PubMedGoogle Scholar
  51. 51.
    Sadler TW, Horton WE Jr (1983) Effects of maternal diabetes on early embryogenesis: the role of insulin and insulin therapy. Diabetes 32: 1070 – 4.PubMedGoogle Scholar
  52. 52.
    Garnham EA, Beck F, Clarke CA, Stanisstreet M (1983) Effects of glucose on rat embryos in culture. Diabetologia 25: 291 – 95.PubMedGoogle Scholar
  53. Lewis NJ, Akazawa S, Freinkel N (1983) Teratogenesis from 0-Hydroxy- butyrate during organogenesis in rat embryo organ culture and enhancement by subteratogenic glucose. Diabetes 32 [Suppl 1]: 11A.Google Scholar
  54. 54.
    Freinkel N, Lewis NJ, Akazawa S, Roth SI, Gorman L (1984) The honeybee syndrome—implications of the teratogenicity of mannose in rat-embryo culture. N Engl J Med 310: 223 – 30.PubMedGoogle Scholar
  55. 55.
    Styrud J, Dahlström VE, Eriksson UJ (1986) Induction of skeletal malformations in the offspring of rats fed a zinc-deficient diet. Uppsala J Med Sci 91: 29 – 36.Google Scholar
  56. 56.
    Diamant YZ, Metzger BE, Freinkel N, Shafir E (1982) Placental lipid and glycogen content in human and experimental diabetes mellitus. Am J Obstet Gynecol 144: 5 – 11.PubMedGoogle Scholar
  57. 57.
    Saintonge J, Coté R (1983) Intrauterine growth retardation and diabetic pregnancy: Two types of fetal malnutrition. Am J Obstet Gynecol 146: 194 - 8.PubMedGoogle Scholar
  58. 58.
    Eriksson UJ, Jansson L (1984) Diabetes in pregnancy: Decreased placental blood flow and disturbed fetal development in the rat. Pediatr Res 18: 735 – 8.PubMedGoogle Scholar
  59. 59.
    New DAT (1978) Whole-embryo culture and the study of mammalian embryos during organogenesis. Biol Rev 53: 81 – 122.PubMedGoogle Scholar
  60. 60.
    Eriksson UJ, Dahlström VE, Styrud J (1985) Metabolically determined teratogenesis: malformations and maternal diabetes. Biochem Soc Trans 13: 79 – 82.PubMedGoogle Scholar
  61. 61.
    Grix A Jr (1982) Invited editorial comment: malformations in infants of diabetic mothers. Am J Med Genet 13: 131 – 7.PubMedGoogle Scholar
  62. 62.
    Johnson JP, Carey JC, Gooch WM III, Petersson J, Bettie JF (1983) Femoral hypoplasia-unusual facies syndrome in infants of diabetic mothers. J Pediatr 102: 866 – 72.PubMedGoogle Scholar
  63. 63.
    Goodner CM, Freinkel N (1961) Carbohydrate metabolism in pregnancy. IV. Studies on the permeability of the rat placenta to I131 insulin. Diabetes 10: 383 – 92.PubMedGoogle Scholar
  64. 64.
    Widness JA, Goldman AS, Susa JB, Oh W, Schwartz R (1983) Impermeability of the rat placenta to insulin during organogenesis. Teratology 28: 327 – 32.PubMedGoogle Scholar
  65. 65.
    Chomette G (1955) Entwicklungsstörnungen nach Insulinschock beim trächtigen Kaninchen. Beitr Pathol Anat 115: 439 – 51.PubMedGoogle Scholar
  66. 66.
    Brinsmade A, Btichner F, Rübsaamen H (1956) Missbildungen am Kanin- chenembryo durch Insulininjektion beim Mettertier. Naturwissenschaften 43: 259.Google Scholar
  67. 67.
    Brinsmade AB (1957) Entwicklungsstörnungen am Kaninchenembryo nach Glukosemangel beim trachtigen Muttertier. Beitr Pathol Anat 117: 140 – 53.PubMedGoogle Scholar
  68. 68.
    Lichtenstein H, Guest GM, Warkany J (1951) Abnormalities of offspring of white rats given protamin zinc insulin during pregnancy. Proc Soc Exp Biol Med 78: 398 – 402.PubMedGoogle Scholar
  69. 69.
    Smithberg M, Runner MN (1963) Teratogenic effects of hypoglycemic treatments in inbred strains of mice. Am J Anat 113: 479 – 89.PubMedGoogle Scholar
  70. 70.
    Love EJ, Kinch RAH, Stevenson JAF (1964) The effect of protamine zinc insulin on the outcome of pregnancy in the normal rat. Diabetes 13: 44 – 8.PubMedGoogle Scholar
  71. 71.
    Hannah RS, Moore KL (1971) Effects of fasting and insulin on skeletal development in rats. Teratology 4: 135 – 40.Google Scholar
  72. 72.
    Ream JR Jr, Weingarten PL, Pappas AM (1970) Evaluation of the prenatal effects of massive doses of insulin in rats. Teratology 3: 29 – 32.PubMedGoogle Scholar
  73. 73.
    Ely JTA. (1981) Hyperglycemia and major congenital anomalies. N Engl J Med 305: 833.PubMedGoogle Scholar
  74. 74.
    Miller E, Hare JW, Cloherty JP, Dunn PJ, Gleason RE, Soeldner S, Kitz- miller JL (1981) Elevated hemoglobin Alc in early pregnancy and major congenital anomalies in infants of diabetic mothers. N Engl J Med 304: 1331 – 4PubMedGoogle Scholar
  75. 75.
    Kennedy L, Baynes JW (1984) Non-enzymatic glycosylation and the chronic complications of diabetes: an overview. Diabetologia 26: 93 - 8.PubMedGoogle Scholar
  76. 76.
    Magee BA, Potezny N, Rofe AM, Conyers AJ (1979) The inhibition of malignant cell growth by ketone bodies. Aust J Exp Biol Med Sci 57: 529 – 39.PubMedGoogle Scholar
  77. 77.
    Bhasin S, Shambaugh III GE (1982) Fetal fuels. V. Ketone bodies inhibit pyrimidine biosynthesis in fetal rat brain. Am J Physiol 243. E234 – 9.PubMedGoogle Scholar
  78. 78.
    Shambaugh GE III, Angulo MC, Koehler RR (1984) Fetal fuels. VII. Ketone bodies inhibit synthesis of purines in fetal rat brain. Am J Physiol 247 (Endocrinol Metab 10): El 11 – 7.Google Scholar
  79. 79.
    Hambidge KM, Neldner KH, Walravens PA (1975) Zinc, acrodermatitis enteropathica, and congenital malformations. Lancet 1: 577 – 8.Google Scholar
  80. 80.
    Jameson S (1976) Effects of zinc deficiency in human reproduction. Thesis Acta Med Scand [Suppl 593]: 1 – 89.Google Scholar
  81. 81.
    Hurley LS (1966) Swenerton H. Congenital malformations resulting from zinc deficiency in rats. Proc Soc Exp Biol Med 123: 692 – 7.PubMedGoogle Scholar
  82. 82.
    Dreosti IE, Grey PC, Wilkins PJ (1972) Deoxyribonucleic acid synthesis, protein synthesis and teratogenesis in zinc-deficient rats. S Afr Med J 46: 1585 – 8.PubMedGoogle Scholar
  83. 83.
    Prasad AS, Oberleas D (1974) Thymidine kinase activity and incorporation of thymidine into DNA in zinc-deficient tissue. J Lab Clin Med 83: 634 – 9.PubMedGoogle Scholar
  84. 84.
    Duncan JR, Hurley LS (1978) Thymidine kinase and DNA polymerase activity in normal and zinc deficient developing rat embryos. Proc Soc Exp Biol Med 159: 39 – 43.PubMedGoogle Scholar
  85. 85.
    Eriksson UJ, Baird JD, Turnbull DM, et al (1985) Timed interruption of insulin therapy in diabetic BB/E rat pregnancy: effects on fetal outcome. 12th Congr IDF, Madrid, Spain, September 23 – 28, 1985 (abstract).Google Scholar
  86. 86.
    Eriksson RSM, Eriksson UJ (1987) Diabetes in pregnancy: effects on fetal outcome by interrupted insulin treatment of the pregnant rat. Submitted for publication.Google Scholar
  87. 87.
    Uriu-Hare J, Stern JS, Reaven GM, et al (1985) The effect of maternal diabetes on trace element status and fetal development in the rat. Diabetes 34: 1031 – 40.PubMedGoogle Scholar
  88. 88.
    Giavini E, Broccia ML, Prati M, et al (1986) Effects of streptozotocin-induced diabetes on fetal development in the rat. Teratology 34: 81 – 8.PubMedGoogle Scholar
  89. 89.
    Zusman I, Ornoy A (1986) The effects of maternal diabetes and high sucrose diets on the intrauterine development of rat fetuses. Diab Res 3: 153 – 9.Google Scholar
  90. 90.
    Eriksson UJ (1987) Importance of genetic predisposition and maternal environment for the occurrence of congenital malformations in offspring of diabetic rats. Accepted for publication.Google Scholar
  91. 91.
    Eriksson UJ, Naeser P, Brolin SE (1986) Increased accumulation of sorbitol in embryos of manifest diabetic rats. Diabetes 35: 1356 – 63.PubMedGoogle Scholar
  92. 92.
    Goldman AS, Baker L, Piddington R, et al (1985) Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid. Proc Natl Acad Sci USA 82: 8227 – 31.PubMedCentralPubMedGoogle Scholar
  93. 93.
    Eriksson UJ, Dahlström E, Styrud J (1984) Metabolism and transport of nutrients in the growth-retarded and malformed offspring of diabetic rats. Diabetologia 27: 272A (abstract).Google Scholar
  94. 94.
    Copeland AD, Porterfield SP (1987) Effects of streptozotocin-induced diabetes in pregnant rats on placental transport and tissue uptake of alfa-amino- isobutyric acid. Horm Metab Res 19: 57 – 61.PubMedGoogle Scholar
  95. 95.
    Eriksson GL, Kihlstrom I, Eriksson UJ (1987) Diabetes in pregnancy: enhanced placental transport of glucose and neutral amino acids from manifest diabetic rats to their fetuses. Submitted for publication.Google Scholar
  96. 96.
    Thomas CR, Eriksson GL, Kihlstrom I, et al (1987) The bidirectional flux of glucose across the placenta of normal and diabetic rats. In: Renold AE, Shafrir E (eds): Lessons from Animal Diabetes II. Proceedings of the second international workshop, Geneva, Switzerland, September 9–13, 1987. John Libbey & Company Ltd, London (in press).Google Scholar
  97. 97.
    Buchanan TA, Schemmer JK, Freinkel N (1986) Embryotoxic effects of brief maternal insulin-hypoglycemia during organogenesis in the rat. J Clin Invest 78: 643 – 9.PubMedCentralPubMedGoogle Scholar
  98. 98.
    Akazawa S, Akazawa M, Yamaguchi Y, et al (1986) Effects of hypoglycemia on early embryogenesis in rat embryo organ culture. Diabetologia 29: 512A (abstract).Google Scholar
  99. 99.
    Sadler TW, Hunter ES (1987) Hypoglycemia: how little is too much for the embryo? Am J Obstet Gynecol 157: 190 – 3.PubMedGoogle Scholar
  100. 100.
    Ornoy A, Zusman I, Cohen AM, et al (1986) Effects of sera from Cohen, genetically determined diabetic rats, Streptozotocin diabetic rats and sucrose fed rats on in vitrodevelopment of early somite rat embryos. Diab Res 3: 43 – 51.Google Scholar
  101. 101.
    Cockroft DL (1984) Abnormalities induced in cultured rat embryos by hyperglycaemia. Br J Exp Pathol 65: 625 – 36.PubMedCentralPubMedGoogle Scholar
  102. 102.
    Reece EA, Pinter E, Leranth CZ, et al (1985) Ultrastructural analysis of malformations of the embryonic neural axis induced by in vitro hyperglycemic conditions. Teratology 32: 363 – 73.PubMedGoogle Scholar
  103. 103.
    Pinter E, Reece EA, Leranth CZ, et al (1986) Yolk sac failure in embryopathy due to hyperglycemia: ultrastructural analysis of yolk sac differentiation associated with embryopathy in rat conceptuses under hyperglycemic conditions. Teratology 33: 73 – 84.PubMedGoogle Scholar
  104. 104.
    Brolin SE, Naeser P, Bodin B, et al (1986) Sorbitol may accumulate in early embryos, but does not seem to cause malformations. Diabetologia 29: 522 (abstract).Google Scholar
  105. 105.
    Hod M, Star S, Passonneau JV, et al (1986) Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis. Biochem Biophys Res Comm 140: 974 – 80.PubMedGoogle Scholar
  106. 106.
    Pinter E, Reece EA, Leranth CA, et al (1986) Arachidonic acid prevents hyperglycemia-associated yolk sac damage and embryopathy. Am J Obstet Gynecol 155: 691 – 702.PubMedGoogle Scholar
  107. 107.
    Horton WE, Sadler TW, Hunter ES (1985) Effects of hyperketonemia on mouse embryonic and fetal glucose metabolism in vitro. Teratology 31: 227 – 33.PubMedGoogle Scholar
  108. 108.
    Horton WE, Sadler TW (1985) Mitochondrial alterations in embryos exposed to B-Hydroxybutyrate in whole embryo culture. Anat Rec 213: 94 – 101.PubMedGoogle Scholar
  109. 109.
    Hunter ES, Sadler TW, Wynn RE (1987) A potential mechanism of DL-beta- hydroxybutyrate-induced malformations in mouse embryos. Am J Physiol 253: E72 – E80.PubMedGoogle Scholar
  110. 110.
    Phillips LS, Fusco AC, Unterman TG (1985) Nutrition and somatomedins. XIV. Altered levels of somatomedins and somatomedin inihibitors in rats with streptozotocin-induced diabetes. Metabolism 34: 765 – 70.PubMedGoogle Scholar
  111. 111.
    Sadler TW, Phillips LS, Balkan W, et al (1986) Somatomedin inhibitors from diabetic rat serum alter growth and development of mouse embryos in culture. Diabetes 35: 861 – 5.PubMedGoogle Scholar
  112. 112.
    Palacin M, Lasuncion MA, Martin A, Herrera E (1985) Decreased uterine blood flow in the diabetic pregnant rat does not modify the augmented glucose transfer to the fetus. Biol Neonate 48: 197 – 203.PubMedGoogle Scholar
  113. 113.
    Freinkel N, Cockroft DL, Lewis NJ, et al (1986) Fuel-mediated teratogenesis during early organogenesis: the effects of increased concentrations of glucose, ketones, or somatomedin inhibitor during rat embryo culture. Am J Clin Nutr 44: 986 – 95.PubMedGoogle Scholar

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  • Ulf J. Eriksson

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