Drug Metabolism (Biotransformation)

  • Ronald J. Tallarida
  • Robert B. Raffa
  • Paul McGonigle
Part of the Springer Series in Pharmacologic Science book series (SSPHARMACOL)


When a drug molecule is introduced into a living organism or tissue, it is immersed in a highly reactive biological mixture in which thousands of chemical reactions are simultaneously proceeding in complex, but organized, patterns. These reactions operate in a coordinated manner within cells to conserve certain endogenous compounds and nutrients and to eliminate potentially harmful foreign material. A drug molecule will very likely be affected by one or more of the many chemical reactions occurring in a cell.


Drug Metabolism Drug Molecule Microsomal Fraction Volatile Anesthetic Microsomal Enzyme 
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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Ronald J. Tallarida
    • 1
  • Robert B. Raffa
    • 1
    • 2
    • 3
  • Paul McGonigle
    • 4
  1. 1.Department of PharmacologyTemple University School of MedicinePhiladelphiaUSA
  2. 2.Janssen Research FoundationUSA
  3. 3.Jefferson Medical CollegePhiladelphiaUSA
  4. 4.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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