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Drug Metabolism (Biotransformation)

  • Ronald J. Tallarida
  • Robert B. Raffa
  • Paul McGonigle
Part of the Springer Series in Pharmacologic Science book series (SSPHARMACOL)

Abstract

When a drug molecule is introduced into a living organism or tissue, it is immersed in a highly reactive biological mixture in which thousands of chemical reactions are simultaneously proceeding in complex, but organized, patterns. These reactions operate in a coordinated manner within cells to conserve certain endogenous compounds and nutrients and to eliminate potentially harmful foreign material. A drug molecule will very likely be affected by one or more of the many chemical reactions occurring in a cell.

Keywords

Drug Metabolism Drug Molecule Microsomal Fraction Volatile Anesthetic Microsomal Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Ronald J. Tallarida
    • 1
  • Robert B. Raffa
    • 1
    • 2
    • 3
  • Paul McGonigle
    • 4
  1. 1.Department of PharmacologyTemple University School of MedicinePhiladelphiaUSA
  2. 2.Janssen Research FoundationUSA
  3. 3.Jefferson Medical CollegePhiladelphiaUSA
  4. 4.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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