Experimental Basis of Bone Marrow Purging with Chemical and Photodynamic Agents
The major stumbling-block in ABMT is the high relapse rate compared to that observed in both allogeneic and syngeneic marrow transplant (1). This is possibly due to occult leukemic cells contaminating the remission marrow. Although the efficacy of the ex-vivo purging procedure has yet to be definitely established in clinical practice, there are indications that cleansing the marrow is associated with improved survival in some cases (1, 2). To meet the obvious need for methods capable of eliminating these cells from autologous marrow, several techniques have been investigated (3–7).
KeywordsLeukemia Cyclophosphamide Biotin Dine Photolysis
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