Viral Infection Following Bone Marrow Transplantation

  • William H. Burns
  • John R. Wingard
Conference paper
Part of the Experimental Hematology Today—1987 book series (HEMATOLOGY, volume 1987)


Virus infections, along with graft-versus-host disease (GVHD), are a major impediment to the success of allogeneic bone marrow transplantation (BMT). The list of viruses often infecting these patients is long. The herpesviruses infect patients following transplant in a manner temporally related to the time of transplant (1) and form the basis of this report.


Acute GVHD Herpes Simplex Virus Infection Bone Marrow Transplantation Patient Allogeneic Recipient Seronegative Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Sarai R, Burns WH, Prentice HG (1984) Herpes virus infections: clinical manifestations and therapeutic strategies in immunocompromised patients. Clin Haematol 13:645–59Google Scholar
  2. 2.
    Sarai R, Burns WH, Laskin OL, Santos GW, Lietman PS (1981) Acyclovir prophylaxis of herpes-simplex-virus infections A randomized, double-blind, controlled trial in bone marrow transplant recipients. N Engl J Med 305:63–7CrossRefGoogle Scholar
  3. 3.
    Wade JC, Newton B, Flournoy N, Meyers JD (1982) Oral acyclovir prophylaxis of herpes simplex virus infecitons after marrow transplant. Intersci Conf Antimicrob Ag Chemother 98Google Scholar
  4. 4.
    Ambinder RF, Burns WH, Lietman PS, Sarai R (1984) Prophylaxis: A strategem to minimize antiviral resistance. Lancet i:1154–55CrossRefGoogle Scholar
  5. 5.
    Burns WH, Sarai R, Santos GW, Laskin OL, Lietman PS, McLaren C, Barry DW (1982) Isolation and characterization of resistant herpes simplex virus following acyclovir therapy. Lancet i:421–3CrossRefGoogle Scholar
  6. 6.
    McLaren C, Chen MS, Ghazzouli I, Sarai R, Burns WH (1985) Drug resistance patterns of herpex simplex virus isolates from patients treated with acyclovir. Antimicrob Ag Chemother 28:740–4Google Scholar
  7. 7.
    Hayward GS, Ambinder R, Ciufo D, Hayward SD, LaFemina RL (1984) Structural organization of human herpesvirus DNA molecules. J Invest Dermatol 83:29s-41sPubMedCrossRefGoogle Scholar
  8. 8.
    Meyers JD, Flournoy N, Wade JC, Hackman RC, McDougall JK, Thomas ED (1983) Biology of interstitial pneumonia after marrow transplantation. In: Recent Advances in Bone Marrow Transplantation, pp 405–23Google Scholar
  9. 9.
    Weiner RS, Bortin MM, Gale RP, Gluckman E, Kay HEM, Kolb H-J, Hartz AJ, Rimm AA (1986) Interstitial pneumonitis after bone marrow transplantation. Ann Int Med 104:168–75PubMedGoogle Scholar
  10. 10.
    Pecego R, Hill R, Appelbaum FR, Amso D, Buckner CD, Fefer A, Thomas ED (1986) Interstitial pneumonitis following autologous bone marrow transplantation. Transplantation 42:515–7PubMedCrossRefGoogle Scholar
  11. 11.
    Quinnan GV, Kirmani N, Rook A, Manischewitz JF, Jackson L, Moreschi G, Santos GW, Sarai R, Burns WH (1982) Cytotoxic T cells in cytomegalovirus infection HLA-restricted T-lymphocyte and non-T lymphocyte cytoxic responses correlate with recovery from cytomegalovirus infection in bone marrow transplant recipients. N Engl J Med 307:6–13CrossRefGoogle Scholar
  12. 12.
    Quinnan GV, Burns WH, Kirmani N, Rook AH, Manischewitz J, Jackson L, Santos GW, Sarai R (1984) HLA-restricted cytotoxic T-lymphocytes are an early immune response and important defense mechanism in cytomegalovirus infections. Rev Infec Dis 6:156–63CrossRefGoogle Scholar
  13. 13.
    Allison AC (1965) Genetic factors in resistance against virus infections. Arch Ges Virusforsch 17:280–94PubMedCrossRefGoogle Scholar
  14. 14.
    Burns WH, Sarai R (1985) Opportunistic viral infections Br Med Bull 41:46–9PubMedGoogle Scholar
  15. 15.
    Zaia JA (1986) The biology of human cytomegalovirus infection after bone marrow transpsantation Int J Cell Clon 4:135–54CrossRefGoogle Scholar
  16. 16.
    Shanley JD, Pesanti EL, Nugent KM (1982) The pathogenesis of pneumonitis due to murine cytomegalovirus. J Infect Dis 146:388–96PubMedCrossRefGoogle Scholar
  17. 17.
    Drew WL, Mintz L, Hoo R, Finley TN (1979) Growth of herpes simplex and cytomegalovirus in cultured human alveolar macrophages. Ann Rev Respir Dis 119:287–91Google Scholar
  18. 18.
    Atkinson K, Meyers JD, Storb R, Prentice RL, Thomas ED (1980) Varicella zoster virus infection after marrow transplantation for aplastic anemia or leukemia. Transplantation 29:47–50PubMedCrossRefGoogle Scholar
  19. 19.
    Locksley RM, Flournoy N, Sullivan KM, Meyers JM (1985) Infection with varicella-zoster virus after marrow transplantation. J Infec Dis 152:1172–81CrossRefGoogle Scholar
  20. 20.
    Ljungman P, Lonnqvist B, Gahrton G, Ringden O, Sundqvist V-A, Wahren B (1986) Clinical and sub-clinicial reactivations of varicella-zoster virus in immunocompromised patients. J Infec Dis 153:840–7CrossRefGoogle Scholar
  21. 21.
    Meyers JD, Wade JC, Shepp DH, Newton B (1984) Acyclovir treatment of varicella-zoster virus infection in the immunocompromised host. Transplantation 37:571–4PubMedCrossRefGoogle Scholar
  22. 22.
    Hope-Simpson RE (1965) The nature of herpes zoster: a long term study and a new hypothesis. Proceedings of the Royal Society of Medicine 58:9–20PubMedGoogle Scholar
  23. 23.
    Meyers JD, Flournoy N, Thomas ED (1980) Cell-mediated immunity to varicella-zoster virus after allogeneic marrow transplant. J Infect Dis 141:479–87PubMedCrossRefGoogle Scholar
  24. 24.
    Bernstein DJ, Lovett MA, Bryson YJ (1984) The effects of acyclovir on antibody response to herpes simplex virus in primary genital herpetic infections. J Infec Dis 150:7–13CrossRefGoogle Scholar
  25. 25.
    Ashley RL, Corey L (1984) Effect of acyclovir treatment of primary genital herpes on the antibody response to herpes simplex virus. J Clin Invest 73:681–8PubMedCrossRefGoogle Scholar
  26. 26.
    Wade JC, Day LM, Crowley JJ, Meyers JD (1984) Recurrent infection with herpes simplex virus after marrow transplantation: role of the specific immune response and acyclovir treatment. J Infect Dis 149:750–6PubMedCrossRefGoogle Scholar
  27. 27.
    Gershon AA (1985) Perspective: Live attenuated varicella zoster. J Infec Dis 152:859–75CrossRefGoogle Scholar
  28. 28.
    Ambinder RF, Wingard JR, Burns WH, Hayward SD, Sarai R, Chin G, Perry HR, Santos GW, Hayward GS (1985) Detection of Epstein-Barr virus DNA in mouthwashes by hybridization. J Clin Microbiol 21:353–6PubMedGoogle Scholar
  29. 29.
    Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, Gallo RC (1986) Isolation of a new virus, HBLV, in patients with lymphopro-liferative disorders. Science 234:595–601CrossRefGoogle Scholar
  30. 30.
    Josephs SF, Salahuddin SZ, Ablashi DV, Schachter F, Wong-Staal F, Gallo RC (1986) Genomic analysis of the human B-lymphotropic virus (HBLV). Science 234:601–3PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • William H. Burns
  • John R. Wingard

There are no affiliations available

Personalised recommendations