Abstract
Between 1951, the year Lorenz et al. [1] first reported rescue of mice and guinea pigs from lethal doses of total body irradiation (TBI) by bone marrow transplantation, and 1967, at least 200 allogeneic bone marrow transplants in humans were attempted; none was successful as measured by long-term disease-free survival [2]. Between 1968, when the first successful allogeneic bone marrow transplants were performed [3–5], and the mid-1970’s, there was progressive improvement in results [6]. Much of the improvement was based on information gained from studies in animal models, selection of patients in earlier phases of disease, improved measures to prevent and treat infection, improved supportive care and, perhaps most important, expanded understanding of the fundamentals of immunogenetics and transplantation biology.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Lorenz E, Uphoff D, Reid TR, et al. (1951) Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst 12:197–201.
Bortin MM (1970) A compendium of reported human bone marrow transplants. Transplantation 9:571–587.
Bach FH, Albertini RJ, Joo P, et al. (1968) Bone marrow transplantation in a patient with Wiskott-Aldrich syndrome. Lancet 2:1364–66.
Gatti RA, Allen HD, Meuwissen HJ, et al. (1968) Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet 2:1366–69.
deKoning J, Dooren LJ, van Bekkum DW, et al. (1969) Transplantation of bone-marrow cells and fetal thymus in an infant with lymphopenic immunological deficiency. Lancet 1:1223–27.
Thomas ED Storb R, Clift RA, et al. (1975) Bone marrow transplantation. N Engl J Med 282:832–43.
Thomas ED Storb R, Clift RA, et al. (1975) Bone marrow transplantation. N Engl J Med 282: 895–902.
Reisner Y, Kapoor N, Kirkpatrick D, et al. (1981) Transplantation for acute leukemia with HLA-A and B nonidentical parental marrow cells fractionated with soybean agglutinin and sheep red blood cells. Lancet 2:327.
Prentice HG, Blacklock HA, Janossy G, et al. (1984) Depletion of T lymphocytes in donor marrow prevents significant graft verus host disease in matched allogeneic leukemia marrow transplant recipients. Lancet 1:472.
Waldmann H, Or R, Hale G, et al. (1984) Elimination of graft versus host disease by in vitro depletion of alloreactive lymphocytes using a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1). Lancet 2:483.
Lowenberg B, Wagemaker G, van Bekkum DW, et al. (1986) Graft-versus-host disease following transplantation of ‘one log’ versus ‘two log’ T-lymphocyte-depleted bone marrow from HLA-identical donors. Bone Marrow Transplantation 1:133–40.
Hale G, Waldmann H (1986) Depletion of T-cells with Campath-1 and human complement. Analysis of GvHD and graft failure in a multi-centre study. Bone Marrow Transplantation 1 (Suppl 1):93.
De Witte T, Janssen J, Drenthe-Schonk A, et al. (1986) A high incidence of autologous repopulation after allogeneic bone marrow transplantation using lymphocyte depleted donor marrow. Exp Hematol 14:448, (Abstract).
Gale RP (1987) T cells, bone marrow transplantation, and immunotherapy: use of monoclonal antibodies. In: Immune interventions in disease. Fahey JL (moderator). Ann Intern Med 106:257–74.
Apperley JF, Jones L, Hale G, et al (1986) Bone marrow transplantation for chronic myeloid leukaemia: T-cell depletion reduces the risk of graft-versus-host disease but may increase the risk of leukaemic relapse. Bone Marrow Transplantation 1:53–66.
Pollard CM, Powles RL, Millar JL, et al (1986) Leukaemic relapse following Campath 1 treated bone marrow transplantation for leukaemia. Lancet 2:1343–44.
Trigg ME, Billing R, Sondei PM, et al (1985) Clinical trial depleting T lymphocytes from donor marrow for matched and mismatched allogeneic bone marrow transplants. Cancer Treat Rep 69:377–86.
Goldman JM, Gale RP, Bortin MM, et al (1987) Bone marrow transplantation for CML in chronic phase: Increased risk of relapse associated with T-cell depletion. Submitted.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag New York Inc.
About this paper
Cite this paper
Bortin, M.M., Horowitz, M.M., Rimm, A.A. (1988). Bone Marrow Transplantation: The Difficulties Ahead. In: Baum, S.J., Santos, G.W., Takaku, F. (eds) Recent Advances and Future Directions in Bone Marrow Transplantation. Experimental Hematology Today—1987, vol 1987. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3762-4_22
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3762-4_22
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8339-3
Online ISBN: 978-1-4612-3762-4
eBook Packages: Springer Book Archive