Abstract
Erradication of leukemia by high dose chemotherapy and total body irradiation (TBI) and the capacity of hemopoietic stem cells to repopulate the marrow form the basic concept of bone marrow transplantation (BMT) in leukemia. First attempts at allogeneic BMT were made soon after the discovery of the hemopoietic stem cell. They all failed because of rejection and Graft-versus-Host disease (GvHD) (1). The recognition of the major histocompatibility complex was the basis of the first successful BMT’s in immune defiency syndromes where HLA-identical siblings served as donors (2–4). Results of BMT in leukemia, however, remained unsatisfactory because it was used almost exclusively for terminally ill patients with end-stage disease.
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References
Bortin MM (1970) A compendium of the reported human bone marrow transplants. Transplantation 9: 571–580
Gatti RA, Meuwissen HJ, Allen HD, Hong RA (1968) Immunologic reconstitution of sex-linked lymphopenic immunologic deficiency. Lancet II: 1366–1369
Bach FH, Albertini RJ, Joo P, Anderson JL, Bortin MM (1968) Bone marrow transplantation in a patient with Wiskott-Aldrich syndrome. Lancet II: 1364–1366
De Koning J, Dooren LJ, van Bekkum DW, van Rood JJ (1969) Transplantation of bone marrow cells and foetal thymus in an infant with lymphopenic immunologic deficiency. Lancet I: 1223–1227
Speck B (1984) Bone marrow transplantation. Acta haemat 72: 145–154
Bortin MM (1986) Increasing utilisation. of bone marrow transplantation. Transplantation 42: 229–234
Cornu P, Speck B, Groff P, Nissen C, Sartorius J, Burri HP, Ohnacker H (1978) Allogeneic BMT for acute leukemia. Pathol Biol 26: 49–50
Speck B, Gratwohl A, Osterwalder B, Signer E, Nissen C, Corneo M, Jeannet M (1983) Allogeneic bone marrow transplantation: The Basel trial with cyclosporine. Transplant Proc. 15: 2617–2619
Gratwohl A, Speck B (1986) Bone marrow transplantation with Ciclosporin. Prog. Allergy 38: 404–431
Häfliger B, Gratwohl A, Tichelli A, Würsch A, Speck B. High-dose Ara-C and VP16 prior to conditioning for bone marrow transplantation in patients with high-risk leukemia. Seminars in Oncology 1987 (in press)
Tichelli A, Walther E, Gratwohl A, Osterwalder B, Speck B (1987) Side effects of total body irradiation before bone marrow transplantation. Basel experience July 1979 to March 1986. Strahlentherapie + Onkologie 163: 245–246
De Witte T, Hoogenhout J, De Pauw B, Holdrinet R, Jansen J, Wessels J, van Daal W, Hustinx T, Haanen C (1986) Depletion of donor lymphocytes by counterflow centrifugation successfully prevents acute graft versus host disease in matched allogeneic Transplantation. Blood 67: 1302–1308
Gratwohl A, Baldomero H, Nissen C, Speck B. Engraftment of T-cell depleted rabbit bone marrow. Acta haemat. 1987 (in press)
Gratwohl A, Tichelli A, Würsch, Wenger R, Nissen C, De Witte T, Speck B (1987) Irradiated donor buffy coat cells for patients with T-cell depleted bone marrow. Bone Marrow Transplantation 2 (Suppl. 1): 157
Gratwohl A, Hermans J, Lyklema A, Zwaan FE (1987) Bone marrow transplantation for leukaemia in Europe. Report from the Leukaemia Working Party 1987. Bone Marrow Transplantation 2 (Suppl. 1): 15–18
Bortin MM, Gale RP (1986) Current status of allogeneic bone marrow transplantation. A report of the International Bone Marrow Transplant Registry. In: Teresaki P (ed.) Clinical Transplants, UCLA Los Angeles, pp 17–28
Butturini A, Bortin MM, Seeger RC, Gale RP. Graft-vs-leukemia following bone marrow transplantation: A model of immunotherapy in man (Submitted for publication)
Prentice HG: Oral communication at the Annual Meeting of the EBMT, March 1–4, 1987 (unpublished)
Gratwohl A, Zwaan FE, Hermans J, Lyklema A (1986) Bone marrow transplantation for leukemia in Europe. Bone Marrow Transplantation 1 (Suppl. 1): 177–181
Speck B, Bortin MM, Champlin R, Goldman JM, Herzig RH, McGlave PB, Messner HA, Weiner RS, Rimm AA (1984) Allogeneic bone marrow transplantation for chronic myelogenous leukaemia. Lancet I: 665–668
Herzig RM, Barrett AJ, Gluckman E, Jacobsen SJ, Masaoka R, Ramsay NKC, Ringden O, Zwaan FE, Bortin MM, Blume KG, Horowitz MM, Marmont M, Prentice HG, Rimm AA, Speck B, Gale RP (1987) Bone marrow transplantation in high-risk acute lymphoblastic leukemia in first an second remission. Lancet I: 786–789
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© 1988 Springer-Verlag New York Inc.
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Speck, B., Gratwohl, A., Tichelli, A., Nissen, C. (1988). Allogeneic Bone Marow Transplantation in Leukemia. In: Baum, S.J., Santos, G.W., Takaku, F. (eds) Recent Advances and Future Directions in Bone Marrow Transplantation. Experimental Hematology Today—1987, vol 1987. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3762-4_21
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DOI: https://doi.org/10.1007/978-1-4612-3762-4_21
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