Part of the
Experimental Hematology Today—1987
book series (HEMATOLOGY, volume 1987)
It has become a tradition to commence important meetings of this society with reminiscence and nostalgia. Bone marrow transplantation, which has a history of only 30 to 40 years, permits this process, since some of the early investigators are still with us. For example, over the past 15 years, we have had three symposia in honor of Egon Lorenz. As we all know, the team of Lorenz, Uphoff and Congdon was involved in the first successful transplantation of syngeneic and allogeneic bone marrow into irradiated mice (1). Subsequently, these investigators theorized that a humoral factor probably was responsible for the radiation protection, as documented by the injection of rat bone marrow into irradiated mice (2).
KeywordsBone Marrow Bone Marrow Transplantation Natl Cancer Inst Allogeneic Bone Marrow Irradiate Mouse
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Lorenz E, Uphoff D, Reid TR, Shelton E: Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst 12:197, 1951.PubMedGoogle Scholar
Congdon CC, Lorenz E: Humoral factor in irradiation protection: Modification of lethal irradiation injury in mice by injection of rat bone marrow. Am J Physiol 176:297, 1954.PubMedGoogle Scholar
Cole LJ, Habermeyer JG, Bond VP: Recovery from acute radiation injury in mice following administration of rat bone marrow. J Natl Cancer Inst 16:1, 1955.PubMedGoogle Scholar
Alpen EL, Baum SJ: Modification of X-radiation lethality by autologous marrow infusion in dogs. Blood 13:1168, 1958.PubMedGoogle Scholar
Gengozian N, Makinodan T: Mortality of mice as affected by variation of the X-ray dose and number of nucleated rat bone marrow cells injected. Cancer Res 17:970, 1957.PubMedGoogle Scholar
© Springer-Verlag New York Inc. 1988