Origin of Zona Pellucida Antigens and Its Relevance to the Development of Contraceptive Vaccine
The zona pellucida (ZP) is an extracellular glycoprotein matrix that closely surrounds the ovum and plays a major role in the process of sperm-egg interaction in mammalian species. In fact, it is the structure to which sperm attach and bind during initial stages of fertilization. Considering its important functional role, the ZP has been recognized as an ideal target for immunocontraception (1,5).
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