Origin of Zona Pellucida Antigens and Its Relevance to the Development of Contraceptive Vaccine
The zona pellucida (ZP) is an extracellular glycoprotein matrix that closely surrounds the ovum and plays a major role in the process of sperm-egg interaction in mammalian species. In fact, it is the structure to which sperm attach and bind during initial stages of fertilization. Considering its important functional role, the ZP has been recognized as an ideal target for immunocontraception (1,5).
KeywordsAdrenal Gland Zona Pellucida Ovarian Follicle Primordial Germ Cell Important Functional Role
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- 1.Dunbar, BS: Antibodies of zona pellucida antigens and their role in fertility, in Wegmann T, Gill T, Camming C, Nisbet-Brown E (eds): Immunology of Reproduction. Oxford, England, Oxford University Press, 1983, pp 506–534.Google Scholar
- 5.Sacco AG: Immunocontraception: Consideration of the zona pellucida as a target antigen, in Wynn RM (ed):Obstetrics and Gynecology Annual vol 10, 1981, pp 1–26.Google Scholar
- 6.Sacco AG, Subramanian MG, Yurewicz EC, et al: Antigenic profile and impact of immunization with zona pellucida antigens in primates, in Talwar GP (ed): Immunological Approaches to Contraception and Promotion of Fertility. New York, Plenum Press, 1986, pp 277–290.Google Scholar