Abstract
The zona pellucida (ZP) is an extracellular glycoprotein matrix that closely surrounds the ovum and plays a major role in the process of sperm-egg interaction in mammalian species. In fact, it is the structure to which sperm attach and bind during initial stages of fertilization. Considering its important functional role, the ZP has been recognized as an ideal target for immunocontraception (1,5).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Dunbar, BS: Antibodies of zona pellucida antigens and their role in fertility, in Wegmann T, Gill T, Camming C, Nisbet-Brown E (eds): Immunology of Reproduction. Oxford, England, Oxford University Press, 1983, pp 506–534.
Guraya SS: Biology of Ovarian Follicles. Berlin-Heidelberg, New York, SpringerVerlag, 1985, pp 1–320.
Kan YH: Development of zona pellucida in the rat oocyte. Am J Anat 1974; 139: 535–565.
Mahi-Brown CA, Yanagimachi R, Hoffmann JD et al: Fertility control in the bitch by active immunization with porcine zonae pellucidae: use of different adjuvants and patterns of estradiol and progesterone levels in estrous cycles. Biol Reprod 1985;32:761–772
Sacco AG: Immunocontraception: Consideration of the zona pellucida as a target antigen, in Wynn RM (ed):Obstetrics and Gynecology Annual vol 10, 1981, pp 1–26.
Sacco AG, Subramanian MG, Yurewicz EC, et al: Antigenic profile and impact of immunization with zona pellucida antigens in primates, in Talwar GP (ed): Immunological Approaches to Contraception and Promotion of Fertility. New York, Plenum Press, 1986, pp 277–290.
Skinner SM, Mills T, Kirchick HJ, et al: Immunization with zona pellucida proteins results in abnormal ovarian follicular differentiation and inhibition of gonadotropin induced steroid secretion. Endocrinology 1984;115:2418–2432.
Upadhyay SN, Zamboni L: Ectopic germ cells: Natural model for the study of germ cell sexual differentiation. Proc Nat Acad Sci USA 1982;79:6584–6588.
Zamboni L, Upadhyay SN: Germ cell differentiation in mouse adrenal glands. J Exp Zoo 1983;228:173–193.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Upadhyay, S.N. (1988). Origin of Zona Pellucida Antigens and Its Relevance to the Development of Contraceptive Vaccine. In: Talwar, G.P. (eds) Contraception Research for Today and the Nineties. Progress in Vaccinology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3746-4_31
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3746-4_31
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8331-7
Online ISBN: 978-1-4612-3746-4
eBook Packages: Springer Book Archive