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Contraception Research for Today and the Nineties pp 285–291Cite as

Should Cell-Mediated Immunity be Considered in the Implementation of Antifertility Vaccines?

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Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 1))

Abstract

Most studies of infertility due to immunological mechanisms have focused on antibody responses to sperm and gestational tissue antigens. Limited experimental data exist to indicate that reproductive tissue antigens also stimulate cellmediated immune responses and that such responses are associated with infertility (3,18,26,32,34). Cell-mediated immunity (CMI) as a cause of infertility has been difficult to address because in vivo and in vitro assays to detect specific CMI responses until lately have provided imprecise information. However, recent technological advances have enabled the purification, characterization, and mass production by genetic engineering of several of the mediators of CMI responses. Our laboratory has begun systematic investigation of the effects of soluble products of activated macrophages and lymphocytes on reproductive tissue viability and function. Our studies to date, which are reviewed here, indicate that these factors may have dramatic effects on fertility. This information, combined with recent data on accessibility of female and male reproductive tracts to immune effectors, indicates that strategies to enhance local cell-mediated immunological responses should be considered for improving the efficacy of antifertility vaccines.

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Authors
  1. Deborah J. Anderson
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  2. Joseph A. Hill
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Editors and Affiliations

  1. National Institute of Immunology, JNU Complex, Shahid Jeet Singh Marg, 110 067, New Delhi, India

    G. P. Talwar

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© 1988 Springer-Verlag New York Inc.

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Anderson, D.J., Hill, J.A. (1988). Should Cell-Mediated Immunity be Considered in the Implementation of Antifertility Vaccines?. In: Talwar, G.P. (eds) Contraception Research for Today and the Nineties. Progress in Vaccinology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3746-4_26

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  • DOI: https://doi.org/10.1007/978-1-4612-3746-4_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8331-7

  • Online ISBN: 978-1-4612-3746-4

  • eBook Packages: Springer Book Archive

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