Safety Evaluation of HCG Vaccine in Primates: Autoantibody Production
The immediate objective of this investigation was to evaluate the possible production of autoantibodies after immunization of baboons with a vaccine prepared from the C-terminal peptide of the β-chain of human chorionic gonadotropin (HCG). In a broader sense, however, the project has served as a paradigm of the immunological problems that arise following immunization with small-chain synthetic peptides. To produce a protein antigenic stimulus, small peptides must be conjugated to a protein carrier and incorporated into an adjuvant. Each component of this complex vaccine mixture has the potential for inducing autoantibody production or of enhancing the level of preexisting natural autoantibodies.
KeywordsHuman Chorionic Gonadotropin Vaccine Conjugate Safety Evaluation Subunit Vaccine Diphtheria Toxoid
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