Dynamic Interactions of the Second Messenger Systems

  • Chiayeng Wang
  • Rajendra K. Sharma
  • Jerry H. Wang

Abstract

The response of living cells to changes in cell environment depends on the production and actions of second messenger molecules. The two most extensively studied second messengers are Ca2+ and cAMP, each of which has been demonstrated to regulate unique metabolic reactions and pathways. Examination of these regulatory reactions suggests that the two second messenger systems also undergo complex interactions during cell activation that serve to modulate the overall cell response.

Keywords

Hydrolysis Phospho Phosphodiesterase Phosphorylase Calmo 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Krebs, E. G., and Beavo, J. A. (1979) Annu. Rev. Biochem.48: 923–959.PubMedCrossRefGoogle Scholar
  2. 2.
    Klee, C. B., Crouch, J. H., and Richman, P. G. (1980) Annu. Rev. Biochem.49: 489–515.PubMedCrossRefGoogle Scholar
  3. 3.
    Ozawa E. (1973) J. Neurochem.20: 1487–1488.PubMedCrossRefGoogle Scholar
  4. 4.
    Brostrom, C. O., Huang, Y. C., Breckenridge, B. McL., and Wolff, D. J. (1975) Proc. Natl. Acad. Sci. USA72: 64–68.PubMedCrossRefGoogle Scholar
  5. 5.
    Small, J. V., and Sobieszek, A. (1977) Eur. J. Biochem.76: 521–530.PubMedCrossRefGoogle Scholar
  6. 6.
    Conti, M. A., and Adelstein, R. S. (1980) Fed. Proc.39: 1569–1573.PubMedGoogle Scholar
  7. 7.
    Shenolikar, S., and Cohen, P. (1978) FEBS Lett. 86: 92–96.PubMedCrossRefGoogle Scholar
  8. 8.
    Sharma, R. K., Tam, S. W., Waisman, D. M., and Wang, J. H. (1980) J. Biol. Chem.255: 11102–11105.PubMedGoogle Scholar
  9. 9.
    Cooper, R. H., Sul, H. S., and Walsh, D. A. (1981) J. Biol. Chem.256: 8030–8038.PubMedGoogle Scholar
  10. 10.
    Kamm, K. E., and Stull, J. T. (1985) Annu. Rev. Pharmacol. Toxicol.25: 59–3620.CrossRefGoogle Scholar
  11. 11.
    Wang, C., Ngai, P. K., Walsh, M. P., and Wang, J. H. (1987) Biochemistry26: 1110–1117.PubMedCrossRefGoogle Scholar
  12. 12.
    Sharma, R. K., Adachi, A., Adachi, K., and Wang, J. H. (1984) J. Biol. Chem.259: 9248–9254.PubMedGoogle Scholar
  13. 13.
    Sharma, R. K., Adachi, A., Adachi, K., and Wang, J. H. (1984) J. Biol. Chem.259: 9248–9254.PubMedGoogle Scholar
  14. 14.
    Sharma, R. K., and Wang, J. H. (1985) Proc. Natl. Acad. Sci. USA82: 2603–2607.PubMedCrossRefGoogle Scholar
  15. 15.
    Sharma, R. K., and Wang, J. H. (1985) J. Biol. Chem.261: 1322–1328.Google Scholar
  16. 16.
    Huang, C. Y., Chau, V., Chock, P. B., Wang, J. H., and Sharma, R. K. (1981) Proc. Natl. Acad. Sci. USA78: 871–874.PubMedCrossRefGoogle Scholar
  17. 17.
    Wolff, D. J., and Brostrom, C. O. (1979) Adv. Cyclic Nucleotide Res.11: 27–88.PubMedGoogle Scholar
  18. 18.
    Blumenthal, D. K., and Stull, J. T. (1980) Biochemistry 19:5608–5614.PubMedCrossRefGoogle Scholar
  19. 19.
    LaPorte, D. C., Toscano, W. A., and Storm, D. R. (1979) Biochemistry18: 2820–2825.PubMedCrossRefGoogle Scholar
  20. 20.
    Piascik, M. T., Wisler, P. L., Johnson, C. L., and Potter, J. D. (1980) J. Biol. Chem.255: 4176–4182.PubMedGoogle Scholar
  21. 21.
    Pallen, C. J., Sharma, R. K., Matsui, H., and Wang, J. H. (1985) Adv. Protein Phosphatase 1: 147–162.Google Scholar
  22. 22.
    Stewart, A. A., Ingebritsen, T. S., Manalan, A., and Klee, C. B. (1982) FEBS Lett. 137: 80–88.PubMedCrossRefGoogle Scholar
  23. 23.
    Killiea, S. D., Brandt, H., Lee, E. Y. C., and Whelan, W. J. (1976) J. Biol. Chem.251: 2363–2368.Google Scholar
  24. 24.
    Khandelwal, R. L., Vandenheede, J. R., and Krebs, E. J. (1976) J. Biol. Chem.251: 4850–4858.PubMedGoogle Scholar
  25. 25.
    Huang, F. L., and Glinsmann, W. H. (1976) Eur. J. Biochem.70: 419–426.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Chiayeng Wang
  • Rajendra K. Sharma
  • Jerry H. Wang

There are no affiliations available

Personalised recommendations