The Role of the Horse in Studies Relative to Malignant Hyperthermia

  • Charles E. Short
  • Nora S. Matthews


Malignant hyperthermia (MH) is now a well recognized syndrome in man and there are extensive efforts to understand the syndrome in both human and animal health.1 The pig has served for a number of years as an experimental model, since a number of characteristics of MH are observed in both man and the pig, including fulminant hyperthermia, muscle rigidity, and a rapid triggering effect by either halothane anesthesia or succinyl-choline.1–4 Similar responses to circulation and ventilation have been observed in both man and swine. Malignant hyperthermia has been reported also in dogs,5,6 horses,7,8 and rabbits.9


Malignant Hyperthermia Malignant Hyperthermia Halothane Anesthesia Malignant Hyperthermia Susceptibility Dantrolene Sodium 
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© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Charles E. Short
  • Nora S. Matthews

There are no affiliations available

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