The Role of the Horse in Studies Relative to Malignant Hyperthermia

  • Charles E. Short
  • Nora S. Matthews

Abstract

Malignant hyperthermia (MH) is now a well recognized syndrome in man and there are extensive efforts to understand the syndrome in both human and animal health.1 The pig has served for a number of years as an experimental model, since a number of characteristics of MH are observed in both man and the pig, including fulminant hyperthermia, muscle rigidity, and a rapid triggering effect by either halothane anesthesia or succinyl-choline.1–4 Similar responses to circulation and ventilation have been observed in both man and swine. Malignant hyperthermia has been reported also in dogs,5,6 horses,7,8 and rabbits.9

Keywords

Foam Respiration Bicarbonate Caffeine Choline 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Short CE (1978) The significance of malignant hyperthermia in animal anesthesia, in Aldrete JA, Britt BA (eds) Proceedings, Second International Symposium on Malignant Hyperthermia, Denver, April 1-3, 1977. New York: Grune & Stratton, pp 175–182Google Scholar
  2. 2.
    Flewellen EH, Nelson TE (1979) Porcine malignant hyperthermia: A method to produce dantrolene prophylaxis and therapeutics. Anesthesiology 51 (Suppl 3S): S248Google Scholar
  3. 3.
    Harrison G. (1977) The control and prevention of malignant hyperthermia in MHS Pigs: Some experimental observations, in Huflsz E, Sanchez-Hernandez J A, Vasconcelds G, Lunn JN (eds) Anaesthesiology, Proceedings of the VI World Congress of Anaesthesiology, Mexico City. Amsterdam: Excerpta Medica, pp 452–454Google Scholar
  4. 4.
    Murphy KSK, Jami L, Petit JM, Zytnicki D (1980) Differential effects of dantrolene sodium on fast and slow motor units, in Abstracts, 54th Annual Meeting FASEB, Anaheim, CA, April 13-18. Fed Proc 39: 579Google Scholar
  5. 5.
    Dagshaw RJ, Cox RH, Rosenberg H (1981) Dantrolene treatment of malignant hyperthermia. J Am Vet Med Assoc 178: 1029Google Scholar
  6. 6.
    Leary SL, Anderson LC, Manning PJ, Bache RJ, Zweber BA (1983) Recurrent malignant hyperthermia. J Am Vet Med Assoc 182: 521–522PubMedGoogle Scholar
  7. 7.
    Short CE, White KK (1978) Anesthetic/surgical stress-induced myopathy (myositis). Part 1: Clinical occurrences, in Proceedings 24th Annual Meeting, American Association of Equine Practitioners, St Louis, MO: American Association of Equine Practitioners, pp 101–106Google Scholar
  8. 8.
    Manley SV, Kelly AB, Dodgson D (1983) Malignant hyperthermia-like reactions in three anesthetized horses. J Am Vet Med Assoc 183: 85–89PubMedGoogle Scholar
  9. 9.
    Durbin CG Jr, Rosenberg H (1979) A laboratory animal model for malignant hyperpyrexia. J Pharmacol Exp Ther 210: 70–74PubMedGoogle Scholar
  10. 10.
    Waldron-Mease E, Klein LV, Rosenberg H, Leitch M (1981) Malignant hyperthermia in a halothane anesthetized horse. J Am Vet Med Assoc 179: 9Google Scholar
  11. 11.
    Hildebrand SV, Howitt GA (1983) Succinylcholine infusion associated with hyperthermia in ponies anesthetized with halothane. Am J Vet Res 44:2280- 2284Google Scholar
  12. 12.
    Hattox JS (1981) Anesthesiology. J Am Vet Med Assoc 245: 2182–2183CrossRefGoogle Scholar
  13. 13.
    Walton J. Diffuse exercise-induced muscle pain of undetermined cause relieved by verapamil. Lancet 1: 993Google Scholar
  14. 14.
    Ryan JF (1977) Treatment of malignant hyperthermia, in Henschel EO (ed) Malignant Hyperthermia: Current Concepts. New York: Appleton-Century-Crofts, Chap 3, pp 47–56Google Scholar
  15. 15.
    Gronert GA (1980) Malignant hyperthermia. Anesthesiology 53: 395–423PubMedCrossRefGoogle Scholar
  16. 16.
    Chapin JW, Chang GL, Wingard DW (1981) Asystole after intravenous dantrolene sodium in pigs. Anesthesiology 54: 527–528CrossRefGoogle Scholar
  17. 17.
    Denborough MA (1980) The pathopharmacology of malignant hyperpyrexia. Pharmacol Ther 9: 357–365PubMedCrossRefGoogle Scholar
  18. 18.
    Kolb ME (1981) Dantrolene sodium intravenous in the treatment of human malignant hyperthermia. Can J Hosp Pharm 34: 47–51Google Scholar
  19. 19.
    Wingard DW (1983) Controversies regarding the prophylactic use of dantrolene for malignant hyperthermia. Anesthesiology 58: 489–490PubMedCrossRefGoogle Scholar
  20. 20.
    Jafek BW, Solomons CC, Masson NC, Mahowald MC, Gumprecht TF (1981) Current concepts of malignant hyperthermia. Otolaryngol Head Neck Surg 89: 891–897PubMedGoogle Scholar
  21. 21.
    Britt BA (1979) Etiology and pathophysiology of malignant hyperthermia. Fed Proc 38: 44–48PubMedGoogle Scholar
  22. 22.
    Flewellen EH, Nelson TE, Jones WP, Arens JF, Wagner DL (1983) Dantrolene dose-response in awake man: Implications for management of malignant hyperthermia. Anesthesiology 59: 275-280Google Scholar
  23. 23.
    Flewellen HH, Nelson TE (1980) Dantrolene dose response in malignant hyperthermia-susceptible ( MHS) swine: Method to obtain prophylaxis and therapeusis. Anesthesiology 52: 303-308Google Scholar
  24. 24.
    Kerr DD, Wingard DW, Gatz EE (1977) Prevention of porcine malignant hyperthermia by oral dantrolene, in Aldrete JA, Britt BA (eds) Proceedings, Second International Symposium on Malignant Hyperthermia, Denver, 1977. New York: Grune & Stratton, pp 499–507Google Scholar
  25. 25.
    Oliven A, Deal EC Jr, Kelsen SG, Cherniack NS (1984) Respiratory response to partial paralysis in anesthetized dogs. J Appl Physiol 56 (6): 1583–1588PubMedCrossRefGoogle Scholar
  26. 26.
    Saltzman LS, Kats RA, Corke BC, Norfleet EA, Heath KR (1984) Hyperkalemia and cardiovascular collapse after dantrolene and verapamil administration in swine, in Abstracts, 58th Congress International Anesthesia Research Society, 1984. Anesth Analg 63: 272Google Scholar
  27. 27.
    Grinberg R, Edelist G, Gordon A (1983) Postoperative malignant hyperthermia episodes in patients who received “safe” anaesthetics. Can Anaesth Soc J 30: 273–276PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Charles E. Short
  • Nora S. Matthews

There are no affiliations available

Personalised recommendations