Anti-idiotypic Antibodies Approach to the Study of the TSH Receptor
Following the binding of thyroid-stimulating hormone (TSH) to its receptor, the receptor undergoes conformational changes which trigger a number of signals including the activation of adenylate cyclase and phospholipase C, hydrolysis of phospholipids, and movement of calcium ions. The ultimate result would be the synthesis and secretion of thyroid hormones. TSH effect is modulated by other hormone and growth factors, the latter contributing to thyroid cell growth in most species. TSH action is terminated by uncoupling of receptor from the cyclase system and disappearance of the high-affinity binding site on thyroid cell as well as action of protein kinase C (1).
KeywordsAdenylate Cyclase Thyroid Cell Protein Blot Idiotypic Network Antiidiotypic Antibody
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