Anti-idiotypic Antibodies Approach to the Study of the TSH Receptor

  • Nadir R. Farid


Following the binding of thyroid-stimulating hormone (TSH) to its receptor, the receptor undergoes conformational changes which trigger a number of signals including the activation of adenylate cyclase and phospholipase C, hydrolysis of phospholipids, and movement of calcium ions. The ultimate result would be the synthesis and secretion of thyroid hormones. TSH effect is modulated by other hormone and growth factors, the latter contributing to thyroid cell growth in most species. TSH action is terminated by uncoupling of receptor from the cyclase system and disappearance of the high-affinity binding site on thyroid cell as well as action of protein kinase C (1).


Adenylate Cyclase Thyroid Cell Protein Blot Idiotypic Network Antiidiotypic Antibody 
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  1. 1.
    Fvarid, N.R., and G. Fahraeus’van Ree. 1987. About the porcine TSH receptor. Acta Endocrinol, (in press).Google Scholar
  2. 2.
    Sege, K., and P.A. Peterson. 1978. Use of anti-idiotypic antibodies as cell- surface receptor probes. Proc. Natl. Acad. Sci. USA 75: 2443.PubMedCrossRefGoogle Scholar
  3. 3.
    Farid, N.R., and T.C.Y. Lo. 1985. Antiidiotypic antibodies as probes for re-ceptor structures and function. Endocrine Rev. 6: 1.CrossRefGoogle Scholar
  4. 4.
    Islam, M N., B.M. Pepper, R. Briones-Urbina, and N. R. Farid. 1983. Bio¬logical activity of anti-thyrotropin anti-idiotypic antibody. Eur. J. Immunol. 13: 57.PubMedCrossRefGoogle Scholar
  5. 5.
    Bako, G., M.N. Islam, and N.R. Farid. 1985. Photoaffinity labelling of the porcine thyrotropin receptor-effect of Graves’ immunoglobulin G and anti- TSH anti-idiotypic antibodies. Clin. Invest. Med. 8: 126.Google Scholar
  6. 6.
    Farid, N.R., R. Briones-Urbina, and J.C. Bear. 1983. Graves’ disease-the thyroid stimulating antibody and immunological networks. Mol. Asp. Med. 6: 355.Google Scholar
  7. 7.
    Farid, N.R. 1987. Graves’ disease. In N.R. Farid (ed.), Immunogenetic aspects of endocrine disorders. Alan R. Liss, Inc., New York. In press.Google Scholar
  8. 8.
    Gaulton, G.N., and M.I. Green. 1986. Idiotypic mimicry of biologic receptors. Annu. Rev. Immunol. 4: 253.CrossRefGoogle Scholar
  9. 9.
    Gaulton, G.N., and M.I. Green. 1986. Idiotypic mimicry of biologic receptors. Annu. Rev. Immunol. 4: 253.CrossRefGoogle Scholar
  10. 10.
    Avivi, A., D. Tramontano, F.S. Ambesi-Impiombato, and J. Schlessinger. 1981. Adenosine 3\5’-monophosphate modulates thyrotropin receptor clus¬tering and thyrotropin activity in culture. Science 214: 1237.PubMedCrossRefGoogle Scholar
  11. 11.
    Farid, N.R., and G. Fahraeus’van Ree. 1987. Non-isotopic study of the TSH receptor. In S. Pal (ed. ), Immunoassay technology. In press.Google Scholar
  12. 12.
    Hawe, B.S., T F. Davies, N.R Farid. 1987. An anti-idiotypic antibody to Graves’ IgG. Autoimmunity. (in press).Google Scholar

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© Springer-Verlag New York Inc. 1988

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  • Nadir R. Farid

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