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Anti-idiotypic Antibodies Approach to the Study of the TSH Receptor

  • Nadir R. Farid

Abstract

Following the binding of thyroid-stimulating hormone (TSH) to its receptor, the receptor undergoes conformational changes which trigger a number of signals including the activation of adenylate cyclase and phospholipase C, hydrolysis of phospholipids, and movement of calcium ions. The ultimate result would be the synthesis and secretion of thyroid hormones. TSH effect is modulated by other hormone and growth factors, the latter contributing to thyroid cell growth in most species. TSH action is terminated by uncoupling of receptor from the cyclase system and disappearance of the high-affinity binding site on thyroid cell as well as action of protein kinase C (1).

Keywords

Adenylate Cyclase Thyroid Cell Protein Blot Idiotypic Network Antiidiotypic Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Nadir R. Farid

There are no affiliations available

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