Anti-Idiotypes, Retrovirus Receptors, and an Idiotypic Network in a Model of Retrovirus-Induced Thymic Leukemia
The concept that idiotypes of immunoglobulin variable regions can mimic epitopes on other kinds of molecules has been applied to the production of antibodies against several kinds of cell surface receptors (1). Starting with a ligand for a receptor, one can prepare an anti-ligand antibody and then an anti-anti-ligand antibody which mimics the ligand and binds to its cell surface receptor. This approach is particularly useful in obtaining antibodies to receptors which are poorly immunogenic, expressed in small amounts on cell surfaces, or cannot easily be copurified with their ligands. One class of receptors which meet these criteria and thus have defied identification and characterization are those for oncogenic retroviruses.
KeywordsMurine Leukemia Virus Envelope Glycoprotein Idiotypic Network Gp70 Molecule Lymph Node Mononuclear Cell
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