Ultrastructural Correlates of Antimycotic Treatment

  • Marcel Borgers
Part of the Current Topics in Medical Mycology book series (CT MYCOLOGY, volume 2)


The descriptive ultrastructure of a large variety of fungal species either grown under in vitro culture conditions or in situ during infection of the host has been reported in detail. Morphologic characterization of yeasts, dimorphic fungi, and filamentous fungi has been done using scanning electron microscopy to elaborate the surface structure, transmission electron microscopy to reveal the internal subcellular organelles, and freeze-fracture electron microscopy to display some intramembranous molecular structures (2, 3, 5, 6, 12, 17, 28, 31, 45, 50, 61, 64, 66, 70, 75, 83, 85, 112, 113, 124). For a long time the detailed description of fungal substructure has been hampered by the lack of adequate methodology. From the early days of explorative research, especially the field of transmission electron microscopy has been encumbered with difficulties of clear-cut visualization, hence obscuring the interpretation of the observations (17).


Yeast Cell Candida Albicans Pityriasis Versicolor Trichophyton Mentagrophytes Azole Derivative 
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© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Marcel Borgers

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