Sites of Vasoactivity in the Pulmonary Circulation Evaluated Using a Low-Viscosity Bolus Method

  • Christopher A. Dawson
  • Thomas A. Bronikowski
  • John H. Linehan
  • David A. Rickaby

Abstract

Because of the importance of pulmonary capillary pressure in the fluid balance of the lungs and the propensity for various pulmonary vasomotor stimuli to cause constriction of pulmonary veins (Dawson, 1984), there has been considerable interest in methods for determining pulmonary capillary pressure and the arteriovenous sites of pulmonary vasoconstriction. A number of approaches have been used, and each approach has had advantages and disadvantages (Agostoni and Piiper, 1962; Bhattacharya and Staub, 1980; Brody et al., 1968; Bronikowski et al., 1985; Dawson et al., 1988; Gaar et al., 1967; Gable and Drake, 1978; Kadowitz et al., 1975; McDonald and Butler, 1967; Michel et al., 1984; Nagasaka et al., 1984; Piiper, 1970; Zhuang et al., 1983). Like several other methods, the low-viscosity bolus method has been an experimental method used in studies of pump-perfused lungs. In such studies it has the potential for providing some unique insights into the influence of vasomotion on the longitudinal distribution of pulmonary vascular resistance and intravascular pressure from pulmonary artery to pulmonary veins. The method, originally introduced by Piiper (1970), has been modified by Brody et al. (1968) and Grimm et al. (1977) and more recently by us (Dawson et al., 1988) in an attempt to improve resolution to take advantage of this potential.

Keywords

Catheter Filtration Serotonin Histamine Norepinephrine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Agostoni E, Piiper J (1962) Capillary pressure and distribution of vascular resistance in isolated lung. Am J Physiol 202:1033–1036,Google Scholar
  2. Bhattacharya J, Staub NC (1980) Direct measurement of microvascular pressures in isolated perfused dog lung. Science 210: 327–328.CrossRefGoogle Scholar
  3. Brody JS, Stemmler EJ, DuBois AB (1968) Longitudinal distribution of vascular resistance in pulmonary arteries, capillaries and veins. J Clin Invest 47: 783–799.CrossRefGoogle Scholar
  4. Bronikowsk TA, Dawson CA, Linehan JH (1985) Limits on continuous distribution of pulmonary vascular resistance versus compliance from outflow occlusion. Microvasc Res 30: 306–313.CrossRefGoogle Scholar
  5. Dawson CA (1984) Role of pulmonary vasomotion in physiology of the lung. Physiol Rev 64: 544–616.Google Scholar
  6. Dawson CA, Bronikowski TA, Linehan JH, Rickaby DA (1988) Distributions of vascular pressure and resistance in the lung. J Appl Physiol 64: 274–284.Google Scholar
  7. Dawson CA, Linehan JH, Bronikowski TA (1989) Pressure and flow in the pulmonary vascular bed. In Weir EK, Reeves JT (eds) Pulmonary Vascular Physiology and Pathophysiology. Marcel Dekker, New York, pp 51–105.Google Scholar
  8. Gaar KA, Taylor AE, Owens LJ, Guy ton AC (1967) Pulmonary capillary pressure and filtration coefficient in the isolated perfused lung. Am J Physiol 213: 910–914.Google Scholar
  9. Gable JC, Drake RE (1978) Pulmonary capillary pressure in intact dog lungs. Am J Physiol 235: H569–H573.Google Scholar
  10. Grimm DJ, Linehan JH, Dawson CA (1977) Longitudinal distribution of vascular resistance in the lung. J Appl Physiol 43: 1093–1101.Google Scholar
  11. Kadowitz PJ, Joiner PD, Hyman AL (1975) Influence of sympathetic stimulation and vasoactive substances on the canine pulmonary veins. J Clin Invest 56: 354–365.CrossRefGoogle Scholar
  12. McDonald IG, Butler J (1967) Distribution of vascular resistance in the isolated perfused dog lung. J Appl Physiol 23: 463–474.Google Scholar
  13. Michel RP, Hakim TS, Chang HK (1984) Pulmonary arterial and venous pressures measured with small catheters in dogs. J Appl Physiol 57: 309–314.Google Scholar
  14. Nagasaka Y, Bhattacharya J, Nanjo S, Gropper MA, Staub NC (1984) Micropuncture measurement of lung microvascular pressure profile during hypoxia in cats. Circ Res 54: 90–95.Google Scholar
  15. Okada RH, Schwan HP (1960) An electrical method to determine hematocrits. IRE Trans Med Electron 7: 188–192.CrossRefGoogle Scholar
  16. Piiper J (1970) Attempts to determine volume, compliance, and resistance to flow of pulmonary vascular compartments. Prog Resp Res 5: 40–52.Google Scholar
  17. Varah JM (1979) A practical examination of some numerical methods for linear discrete ill-posed problems. SI AM Rev 21: 100–111.MathSciNetMATHCrossRefGoogle Scholar
  18. Wagner PD (1982) Calculating the distribution of ventilation-perfusion ratios from inert gas elimination data. Fed Proc 41: 136–139.Google Scholar
  19. Zhuang FY, Fung YC, Yen RT (1983) Analysis of blood flow in cat’s lung with detailed anatomical and elasticity data. J Appl Physiol 55: 1341–1348.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Christopher A. Dawson
  • Thomas A. Bronikowski
  • John H. Linehan
  • David A. Rickaby

There are no affiliations available

Personalised recommendations