Sites of Vasoactivity in the Pulmonary Circulation Evaluated Using a Low-Viscosity Bolus Method

  • Christopher A. Dawson
  • Thomas A. Bronikowski
  • John H. Linehan
  • David A. Rickaby


Because of the importance of pulmonary capillary pressure in the fluid balance of the lungs and the propensity for various pulmonary vasomotor stimuli to cause constriction of pulmonary veins (Dawson, 1984), there has been considerable interest in methods for determining pulmonary capillary pressure and the arteriovenous sites of pulmonary vasoconstriction. A number of approaches have been used, and each approach has had advantages and disadvantages (Agostoni and Piiper, 1962; Bhattacharya and Staub, 1980; Brody et al., 1968; Bronikowski et al., 1985; Dawson et al., 1988; Gaar et al., 1967; Gable and Drake, 1978; Kadowitz et al., 1975; McDonald and Butler, 1967; Michel et al., 1984; Nagasaka et al., 1984; Piiper, 1970; Zhuang et al., 1983). Like several other methods, the low-viscosity bolus method has been an experimental method used in studies of pump-perfused lungs. In such studies it has the potential for providing some unique insights into the influence of vasomotion on the longitudinal distribution of pulmonary vascular resistance and intravascular pressure from pulmonary artery to pulmonary veins. The method, originally introduced by Piiper (1970), has been modified by Brody et al. (1968) and Grimm et al. (1977) and more recently by us (Dawson et al., 1988) in an attempt to improve resolution to take advantage of this potential.


Pulmonary Vein Capillary Pressure Pulmonary Vascular Resistance Cumulative Volume Volume Segment 
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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Christopher A. Dawson
  • Thomas A. Bronikowski
  • John H. Linehan
  • David A. Rickaby

There are no affiliations available

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