Abstract
The transient pressure and flow data obtained following rapid occlusion of the arterial inflow and/or venous outflow from a lung lobe contain information about the arterial-to-venous distribution of vascular resistance (R) relative to the distribution of vascular compliance (C) (Bronikowski et al., 1985; Bshouty et al., 1987; Dawson et al, 1982; Hakim et al., 1979, 1982, 1983; Holloway et al., 1983; Rippe et al., 1987; Rock et al., 1985). Interest in this approach has, to a large extent, centered around the potential for following changes in microvascular pressure and determining the arterial or venous site of action of vasomotor stimuli. In the following discussion we will present some of our ideas on the information content of occlusion data as interpreted using mathematical models in an attempt to provide useful parameters descriptive of the pulmonary microvascular bed.
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Linehan, J.H., Dawson, C.A., Bronikowski, T.A., Rickaby, D.A. (1989). Sites of Vasoactivity in the Pulmonary Circulation Evaluated Using Rapid Occlusion Methods. In: Lee, JS., Skalak, T.C. (eds) Microvascular Mechanics. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3674-0_8
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DOI: https://doi.org/10.1007/978-1-4612-3674-0_8
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