RNA Polymerase III and Transcription of 5S Ribosomal DNA

  • John J. Furth

Abstract

In 1959 when I went to work in Jerard Hurwitz’s laboratory, bacterial enzymes that synthesized DNA and RNA had been discovered. There was good reason to believe that the bacterial DNA polymerase was responsible for the replication of DNA. However, it appeared unlikely that the bacterial enzyme that synthesized RNA, polynucleotide phosphorylase, was responsible for the in vivo synthesis of RNA. A template was not required, and the concentrations of ribonucleoside diphosphates required for synthesis were much higher than present in the cell. (Although no eukaryotic counterpart of the bacterial enzyme had been found, this in itself was not a serious objection).

Keywords

Shale Compaction Stein Creatine Triphosphate 

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References

  1. 1.
    Furth, J.J., Hurwitz, J., Krug, R., and Alexander, M. (1961) J. Biol. Chem. 236, 3317–3322.PubMedGoogle Scholar
  2. 2.
    Hurwitz, J., Bresler A., and Diringer, R. (1960) Biochem. Biophys. Res. Commun. 3, 15–19.CrossRefGoogle Scholar
  3. 3.
    Furth, J.J., Hurwitz, J., and Goldmann, M. (1961) Biochem. Biophys. Res. Commun. 4, 362–367.PubMedCrossRefGoogle Scholar
  4. 4.
    Furth, J.J., Hurwitz, J., and Anders, M. (1962) J. Biol. Chem. 237, 2611–2619.PubMedGoogle Scholar
  5. 5.
    Hurwitz, J., Furth, J.J., Anders, M., and Evans, A. (1962) J. Biol. Chem. 237, 3752–3759.PubMedGoogle Scholar
  6. 6.
    Josse, J., Kaiser, A.D., and Kornberg, A. (1961) J. Biol. Chem. 236, 864–875.PubMedGoogle Scholar
  7. 7.
    Stevens, A. (1960) Biochem. Biophys. Res. Commun. 3, 92–96.CrossRefGoogle Scholar
  8. 8.
    Weiss, S.B., and Nakamoto, T. (1961) Proc. Natl. Acad. Sci. USA 47, 1400–1465.PubMedCrossRefGoogle Scholar
  9. 9.
    Weiss, S.B., and Gladstone, L. (1959). J. Am. Chem. Soc. 81, 4118–4119.CrossRefGoogle Scholar
  10. 10.
    Spiegelman, S. (1958) In Recent Progress in Microbiology, 81–103, Tunevall, T.G. (ed.). Thomas, Springfield, Illinois.Google Scholar
  11. 11.
    Chamberlin, M., and Berg, P. (1962) Proc. Natl. Acad. Sci. USA 48, 81–94.PubMedCrossRefGoogle Scholar
  12. 12.
    Furth, J.J., and Loh, P. (1963) Biochem. Biophys. Res. Commun. 13, 100–105.CrossRefGoogle Scholar
  13. 13.
    Furth, J.J., and Ho, P. (1965) J. Biol. Chem. 240, 2602–2606.PubMedGoogle Scholar
  14. 14.
    Ramuz, M., Doly, J., Mandel, P., and Chambon, P. (1965) Biochem. Biophys. Res. Commun. 19, 114–120.CrossRefGoogle Scholar
  15. 15.
    Ballard, P., and Williams-Ashman, H.G. (1966) J. Biol. Chem. 241, 1602–1615.PubMedGoogle Scholar
  16. 16.
    Roeder, R.G., and Rutter, N.J. (1970) Proc. Natl. Acad. Sci. USA 65, 675–682.PubMedCrossRefGoogle Scholar
  17. 17.
    Wieland, T.H. (1968) Science 159, 946–952.PubMedCrossRefGoogle Scholar
  18. 18.
    Widnell, C.C., and Tata, J.R. (1966) Biochim. Biophys. Acta 123, 478–492.PubMedGoogle Scholar
  19. 19.
    Chambon, P., Ramuz, M., Mandel, P., and Doly, J. (1968) Biochim. Biophys. Acta 157, 504–519.Google Scholar
  20. 20.
    Zylber, E.A., and Penman, S. (1971) Proc. Natl. Acad. Sci. USA 68, 2861–2865.PubMedCrossRefGoogle Scholar
  21. 21.
    Suzuki, Y., and Giza, P.E. (1976) J. Mol. Biol. 107, 183–206.PubMedCrossRefGoogle Scholar
  22. 22.
    Weinmann, R., and Roeder, R.G. (1974) Proc. Natl. Acad. Sci. USA 71, 1790–1794.PubMedCrossRefGoogle Scholar
  23. 23.
    Weil, P.A., and Blatti, S.P. (1976) Biochemistry 15, 1500–1509.PubMedCrossRefGoogle Scholar
  24. 24.
    Reddy, R., Henning, D., Das, G., Harless, M., and Wright, D. (1987) J. Biol. Chem. 262, 75–81.PubMedGoogle Scholar
  25. 25.
    Zieve, G., Benecke, B.J., and Penman, S. (1977) Biochemistry 16, 4520–4525.PubMedCrossRefGoogle Scholar
  26. 26.
    Reichel, R., and Benecke, B.-J. (1980) Nucleic Acids Res. 8, 225–234.PubMedCrossRefGoogle Scholar
  27. 27.
    Glickman, J.N., Howe, J.G., and Steitz, J.A. (1988) J. Virol. 62, 902–911.PubMedGoogle Scholar
  28. 28.
    Black, D.L., and Steitz, J.A. (1986) Cell 46, 697–704.PubMedCrossRefGoogle Scholar
  29. 29.
    Krüger, W., and Benecke, B.-J. (1987) J. Mol. Biol. 195, 31–41.PubMedCrossRefGoogle Scholar
  30. 30.
    Furth, J.J., and Austin, G.E. (1970) Cold Spring Harbor Symp. Quant. Biol. 35, 641–648.Google Scholar
  31. 31.
    Atikkan, E.E., and Furth, J.J. (1977) Cell Differ. 6, 253–262.PubMedCrossRefGoogle Scholar
  32. 32.
    Ackerman, S., and Furth, J.J. (1979) Biochemistry 18, 3243–3248.PubMedCrossRefGoogle Scholar
  33. 33.
    Parker, C.S., and Roeder, R.G. (1977) Proc. Natl. Acad. Sci. USA 74, 44–48.PubMedCrossRefGoogle Scholar
  34. 34.
    Wu, G.-J. (1978) Proc. Natl. Acad. Sci. USA 75, 2175–2179.PubMedCrossRefGoogle Scholar
  35. 35.
    Segall, J., Matsui, T., and Roeder, R.G. (1980) J. Biol. Chem. 255, 11986–11991.PubMedGoogle Scholar
  36. 36.
    Lasser, A.B., Martin, P.L., and Roeder, R.G. (1983) Science 222, 740–748.CrossRefGoogle Scholar
  37. 37.
    Ottonello, S., Rivier, D.H., Doolittle, G.M., Young, L.S., and Sprague, K.U. (1987) EMBO J. 6, 1921–1927.PubMedGoogle Scholar
  38. 38.
    Yoshinaga, S.K., Boulanger, P.A., and Berk, A.J. (1987) Proc. Natl. Acad. Sci. USA 84, 3585–3589.PubMedCrossRefGoogle Scholar
  39. 39.
    Hwu, H.R., Roberts, J.W., Davidson, E.H., and Britten, R.J. (1986) Proc. Natl. Acad. Sci. USA 83, 3875–3879.PubMedCrossRefGoogle Scholar
  40. 40.
    Ullu, E., and Tschudi, C. (1984) Nature 312, 171–172.PubMedCrossRefGoogle Scholar
  41. 41.
    Kariya, Y., Kato, K., Hayashizaki, Y., Himeno, S., Tarui, S., and Matsubara, K. (1987) Gene 53, 1–10.PubMedCrossRefGoogle Scholar
  42. 42.
    Jelinek, W.R., and Schmid, C.W. (1982) Annu. Rev. Biochem. 51, 813–844.PubMedCrossRefGoogle Scholar
  43. 43.
    Carlson, D.P., and Ross, J. (1986) Mol. Cell Biol. 6, 3278–3282.PubMedGoogle Scholar
  44. 44.
    McKinnon, R.D., Shinnick, T.M., and Sutcliffe, J.G. (1986) Proc. Natl. Acad. Sci. USA 83, 3751–3755.PubMedCrossRefGoogle Scholar
  45. 45.
    Furth, J.J. (1985) Biochem. Biophys. Res. Commun. 131, 551–556.PubMedCrossRefGoogle Scholar
  46. 46.
    Furth, J.J., and Su, C.-Y. (1986) Biochem. J. 237, 827–835.PubMedGoogle Scholar
  47. 47.
    Sakonju, S., Bogenhagen, D.F., and Brown, D.D. (1980) Cell 19, 13–25.PubMedCrossRefGoogle Scholar
  48. 48.
    Bogenhagen, D.F., Sakonju, S., and Brown, D.D. (1980) Cell 19, 27–35.PubMedCrossRefGoogle Scholar
  49. 49.
    Ciliberto, G., Castagnoli, L., and Cortese, R. (1983) Curr. Topics Dev. Biol. 18, 59–88.CrossRefGoogle Scholar
  50. 50.
    Morton, D.G., and Sprague, K.U. (1984) Proc. Natl. Acad Sci. USA 81, 5519–5522.PubMedCrossRefGoogle Scholar
  51. 51.
    Wolffe, A.P., and Brown, D.D. (1988) Science 241, 1625–1632.CrossRefGoogle Scholar
  52. 52.
    Hatlen, L., and Attardi, G. (1971) J. Mol. Biol. 56, 535–553.PubMedCrossRefGoogle Scholar
  53. 53.
    Steffensen, D.M., Duffey, P., and Prensky, W. (1974) Nature 252, 741–743.PubMedCrossRefGoogle Scholar
  54. 54.
    Atwood, K.C., Yu, M.T., Johnson, L.D., and Henderson, A.S. (1975) Cytogenet. Cell Genet. 15, 50–54.PubMedCrossRefGoogle Scholar
  55. 55.
    Stambrook, P.J. (1976) Nature 259, 639–641.PubMedCrossRefGoogle Scholar
  56. 56.
    Hart, R.P., and Folk, W.R. (1982) J. Biol. Chem. 257, 11706–11711.PubMedGoogle Scholar
  57. 57.
    Emerson, B.M., and Roeder, R.G. (1984) J. Biol. Chem. 259, 7916–7925.PubMedGoogle Scholar
  58. 58.
    Doran, J.L., Bingle, W.H., and Roy, K.L. (1987) Nucleic Acids Res. 15, 6297.PubMedCrossRefGoogle Scholar
  59. 59.
    Reddy, R., Henning, D., Rothblum, L., and Busch, H. (1986) J. Biol. Chem. 261, 10618–10623.PubMedGoogle Scholar
  60. 60.
    Arnold, G.J., Kahnt, B., Herrenknecht, K., and Gross, H.J. (1987) Gene 60, 137–144.PubMedCrossRefGoogle Scholar
  61. 61.
    McConkey, G.A., and Bogenhagen, D.F. (1987) Mol. Cell. Biol. 7, 486–494.PubMedGoogle Scholar
  62. 62.
    Peiler, T., Hamm, J., and Roeder, R.G. (1987) Cell 48, 91–100.CrossRefGoogle Scholar
  63. 63.
    Sharp, S.J., and Garcia, A.D. (1988) Mol. Cell. Biol. 8, 1266–1274.PubMedGoogle Scholar
  64. 64.
    Engelke, D.R., Ng, S.-Y., Shastry, B.S., and Roeder, R.G. (1980) Cell 19, 717–728.PubMedCrossRefGoogle Scholar
  65. 65.
    Sakonju, S., Brown, D.D., Engelke, D., Ng, S.-Y., Shastry, B.S., and Roeder, R.G. (1981) Cell 23, 665–669.PubMedCrossRefGoogle Scholar
  66. 66.
    Shastry, B.S., Ng, S.-Y., and Roeder, R.G. (1982) J. Biol. Chem. 257, 12979–12986.PubMedGoogle Scholar
  67. 67.
    Bieker, J.J., Martin, P.L., and Roeder, R.G. (1985) Cell 40, 119–127.PubMedCrossRefGoogle Scholar
  68. 68.
    Carey, M.F., Gerrard, S.P., and Cozzarelli, N.R. (1986) J. Biol. Chem. 261, 4309–4317.PubMedGoogle Scholar
  69. 69.
    Setzer, D.R., and Brown, D.D. (1985) J. Biol. Chem. 260, 2483–2492.PubMedGoogle Scholar
  70. 70.
    Bogenhagen, D.F., Wormington, W.M., and Brown, D.D. (1982) Cell 28, 413–421.PubMedCrossRefGoogle Scholar
  71. 71.
    Bogenhagen, D.F., and Brown, D.D. (1981) Cell 24, 261–270.PubMedCrossRefGoogle Scholar
  72. 72.
    Rinke, J., and Steitz, J.A. (1982) Cell 29, 149–159.PubMedCrossRefGoogle Scholar
  73. 73.
    Cozzarelli, N.R., Gerrard, S.P., Schlissel, M., Brown, D.D., and Bogenhagen, D.F. (1983) Cell 34, 829–835.PubMedCrossRefGoogle Scholar
  74. 74.
    Watson, J.B., Chandler, D.W., and Gralla, J.D. (1984) Nucleic Acids Res. 12, 5369–5384.PubMedCrossRefGoogle Scholar
  75. 75.
    Weil, P.A., Segall, J., Harris, B., Ng, S.-Y., and Roeder, R.G. (1979) J. Biol. Chem. 284, 6163–6173.Google Scholar
  76. 76.
    Lagaye, S., Barque, J.-P., LeMaire, M., Denis, H., and Larsen, C.-J. (1988) Nucleic Acids Res. 16, 2473–2487.PubMedCrossRefGoogle Scholar
  77. 77.
    Seifart, K.H., Wang, L., Waldschmidt, R., Jahn, D., and Wingender, E. (1989) J. Biol. Chem. 264, 1702–1709.PubMedGoogle Scholar
  78. 78.
    Selker, E.U., Morzycka-Wroblewska, L., Stevens, J.N., and Metzenberg, R.L. (1986) Mol. Gen. Genet. 205, 189–192.PubMedCrossRefGoogle Scholar
  79. 79.
    Garcia, A.D., O’Connell, A.M., and Sharp, S.J. (1987) Mol. Cell. Biol. 7, 2046–2051.PubMedGoogle Scholar
  80. 80.
    Murphy, S., Di Liegro, C., and Melli, M. (1987) Cell 51, 81–87.PubMedCrossRefGoogle Scholar
  81. 81.
    Sollner-Webb, B. (1988) Cell 52, 153–154.PubMedCrossRefGoogle Scholar
  82. 82.
    Wilson, G.N. (1982) In The Cell Nucleus, 287–318, Vol. X, Busch, H. (ed.). Academic Press, New York.Google Scholar
  83. 83.
    Baker, S.M., and Piatt, T. (1986) Cell 47, 839–840.PubMedCrossRefGoogle Scholar
  84. 84.
    Worton, R.G., Sutherland, J., Sylvester, J.E., Willard, H.F., Bodrug, S., Dube, I., Duff, C., Kean, V., Ray, P.N., and Schmickel, R.D. (1988) Science 239, 63–68.CrossRefGoogle Scholar
  85. 85.
    Taylor, J.H. (1987) Results Probl. Cell Differ. 14, 173–196.PubMedGoogle Scholar
  86. 86.
    Guinta, D.R., and Korn, L.J. (1986) Mol. Cell. Biol. 6, 2536–2542.PubMedGoogle Scholar
  87. 87.
    Cutroneo, K.R., Sterling, K.M., and Shull, S. (1986) In Regulation of Matrix Accumulation, 119–176, Mecham, R.P. (ed.). Academic Press, New York.Google Scholar
  88. 88.
    Myers, J.C., Howard, P.S., Jelen, A.M., Dion, A.S., and Macarak, E.J. (1987) J. Biol. Chem. 262, 9231–9238.PubMedGoogle Scholar
  89. 89.
    Pöschl, E., Pollner, R., and Kühn, K. (1988) EMBO J. 7, 2687–2695.PubMedGoogle Scholar
  90. 90.
    Soininen, R., Huotari, M., Hostikka, S.L., Prockop, D.J., and Tryggvason, K. (1988) J. Biol. Chem. 263, 17217–17220.PubMedGoogle Scholar
  91. 91.
    Burbelo, P.D., Martin, G.R., and Yamada, Y. (1988) Proc. Natl. Acad. Sci. USA 85, 9679–9682.PubMedCrossRefGoogle Scholar
  92. 92.
    Myers, J.C., and Emanuel, B.S. (1987) Collagen Rel. Res. 7, 149–159.Google Scholar
  93. 93.
    Fletcher, C., Heintz, N., and Roeder, R.G. (1987) Cell 51, 773–781.PubMedCrossRefGoogle Scholar
  94. 94.
    Meyuhas, O., Thompson, E.A., and Perry, R.P. (1987) Mol. Cell. Biol. 7, 2691–2699.PubMedGoogle Scholar
  95. 95.
    Rhoads, D.D., and Roufa, D.J. (1987) Mol. Cell. Biol. 7, 3767–3774.PubMedGoogle Scholar
  96. 96.
    Mahajan, P.B., and Thompson, E.A. (1987) J. Biol. Chem. 262, 16150–16156.PubMedGoogle Scholar
  97. 97.
    Leibowitz, R.D., Weinberg, R.A., and Penman, S. (1973) J. Mol. Biol. 73, 139–144.PubMedCrossRefGoogle Scholar
  98. 98.
    Gokal, P.K., Cavanaugh, A.H., and Thompson, E.A. (1986) J. Biol. Chem. 261, 2536–2541.PubMedGoogle Scholar
  99. 99.
    Tower, J., and Sollner-Webb, B. (1988) Mol. Cell. Biol. 8, 1001–1005.PubMedGoogle Scholar
  100. 100.
    Allison, L.A., Moyle, M., Shales, M., and Ingles, C. (1985) Cell 42, 599–610.PubMedCrossRefGoogle Scholar
  101. 101.
    Mann, C., Buhler, J.-M., Treich, I., and Sentenac, A. (1987) Cell 49, 627–637.CrossRefGoogle Scholar
  102. 102.
    DeLozier-Blanchet, C.D., Walt, H., and Engel, E. (1986) Cytogenet. Cell Genet. 41, 107–113.PubMedCrossRefGoogle Scholar
  103. 103.
    Amaldi, F., and Buongiorno-Nardelli, M. (1971) Exp. Cell Res. 65, 329–334.PubMedCrossRefGoogle Scholar
  104. 104.
    Human Gene Mapping 9 (1987) Cytogenet. Cell Genet. 46, 1–762.CrossRefGoogle Scholar
  105. 105.
    Culotta, V., and Sollner-Webb, B. (1988) Cell 52, 585–597.PubMedCrossRefGoogle Scholar
  106. 106.
    Kmiec, E.B., Ryoji, M., and Worcel, A. (1986) Proc. Natl. Acad. Sci. USA 83, 1305–1309.PubMedCrossRefGoogle Scholar
  107. 107.
    Tripputi, P., Emanuel, B.S., Croce, C.M., Green, L.G., Stein, G.S., and Stein, J. L. (1986) Proc. Natl. Acad. Sci. USA 83, 3185–3188.PubMedCrossRefGoogle Scholar
  108. 108.
    Dignam, J.D., Lebovitz, R.M., and Roeder, R.G. (1983) Nucleic Acids Res. 11, 1475–1489.PubMedCrossRefGoogle Scholar
  109. 109.
    Ackerman, S., Keshgegian, A.A., Henner, D., and Furth J.J. (1979) Biochemistry 18, 3232–3242.PubMedCrossRefGoogle Scholar
  110. 110.
    Little, R.D., and Braaten, D.C. (1989) Genomics 4, 376–383.PubMedCrossRefGoogle Scholar

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© Springer-Verlag New York Inc. 1989

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  • John J. Furth

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