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Pharmacokinetics of Ivermectin in Animals and Humans

  • David W. Fink
  • Arturo G. Porras

Abstract

The pharmacokinetic properties of ivermectin are a function of the species in which the compound is studied. Ivermectin is effective against parasites in a wide variety of hosts—including cattle, sheep, dogs, swine, and horses. A previous review of ivermectin has described the effects of formulation and route of administration on its pharmacokinetic properties in animals (Lo et al. 1985). That publication included examples of formulation modifications directed toward the development of oral and parenteral dosage forms; it also illustrated the use of drug plasma concentrations for characterizing the drug and for modifying formulations for specific efficacy. The following summary presents the results of representative pharmacokinetic and bioavailability studies of this drug in different animal species and in humans. It includes descriptions of the experimental procedures as well as the various measurement techniques used in these studies to describe the pharmacokinetic properties of ivermectin.

Keywords

Propylene Glycol Peak Plasma Concentration Micellar Solution Bioavailability Study Single Intravenous Bolus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • David W. Fink
    • 1
  • Arturo G. Porras
    • 2
  1. 1.Department of Animal Formulation DevelopmentMerck Sharp & Dohme Research LaboratoriesRahwayUSA
  2. 2.Department of Drug MetabolismMerSharp & Dihme Research LaboratoriesWest PointUSA

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