Abstract
Abamectin (MK-0936) is a natural fermentation product of Streptomyces avermitilis. Ivermectin (MK-0933) is a synthetic derivative of abamectin. The chemical structure of abamectin differs from ivermectin only in the bond between carbons 22 and 23; abamectin has a double bond where ivermectin has a single bond and additional hydrogens on C-22 and C-23 (Figure 6.1). Both compounds are a mixture of homologous products with B1a and B1b components. The B1b component differs chemically from the B1a component by only 1 methylene (CH2) unit at the 26-carbon position: the ethyl group (C2H5) is a methyl group (CH3) in the B1b form. Abamectin and ivermectin are defined as containing a minimum of 80% B1a, and a maximum of 20% B1b components. Studies in our laboratories have clearly demonstrated that the individual components have very similar biological and toxicological properties and, for all practical purposes, can be considered equivalent.
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© 1989 Springer-Verlag New York Inc.
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Lankas, G.R., Gordon, L.R. (1989). Toxicology. In: Campbell, W.C. (eds) Ivermectin and Abamectin. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3626-9_6
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DOI: https://doi.org/10.1007/978-1-4612-3626-9_6
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