Abstract
As part of the overall avermectin development program, target animal safety studies were conducted in many countries by Merck personnel and by independent investigators in universities and other research institutions. In many instances anticipated commercial formulations were studied, but during early development and when excessive dosing demanded, alternative or more concentrated formulations were used. The various test formulations were compared for safety by bridging studies involving assessment of tolerance and bioavailability. Control groups were given vehicle, saline, or left untreated; many studies included both treated and untreated controls.
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© 1989 Springer-Verlag New York Inc.
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Pulliam, J.D., Preston, J.M. (1989). Safety of Ivermectin in Target Animals. In: Campbell, W.C. (eds) Ivermectin and Abamectin. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3626-9_10
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DOI: https://doi.org/10.1007/978-1-4612-3626-9_10
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