Background, Goals, and Experimental Design
The Tenth International Histocompatibility Workshop component concerning T-cell recognition of HLA class II molecules was designed with careful attention to the overall Workshop structure. Our goal was to design a collaborative study which could stand as an independent and self-sufficient scientific investigation, but which, at the same time, could be integrated with the other Workshop efforts. The Workshop B-Lymphoblastoid Cell Panel was an obvious connecting link to the other HLA class II components around which such a study could be built. We hoped that cellular studies of the cell panel might indeed point out functionally relevant polymorphism between the cell lines, which would complement the information gained from the Southern blot, cDNA sequencing, and protein chemistry components.
KeywordsNormal Human Serum Panel Analysis Cellular Study Core Antibody Cell Line Panel
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