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DRw6 (DRw13, DRw14): 2-D Gel Patterns

  • Dominique Charron
  • Pierre Hermans
  • Manfred Ballas
  • Zacharie Brahmi
  • Ernette du Toit
  • Robert Martell
  • Laurine Bow
  • Ronald Bontrop
Conference paper

Abstract

DRw6 (DRw13,DRw14) haplotypes were previously considered to be the most enigmatic group of HLA class II specificities. This was largely due to the lack of monospecific anti-DRw6 alloantisera. Through the combined efforts of serology, cellular typing, and biochemistry, it has been possible over the past few years to recognize individual molecular variants of DRβ and DQβ chains and their associations, thus defining several DRw6 haplotypes (1,2). A common feature of all the DRw6 (DRw13,DRw14) haplotypes is the presence of at least one DRβ product belonging to the DRw52 supertypic specificities, thus ranking the DRw6 haplo types among the DRw52 associated haplotypes with DR3 and 5.

Keywords

Haplo Type Chain Pattern DQAI Gene Workshop Study Enigmatic Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York 1989

Authors and Affiliations

  • Dominique Charron
  • Pierre Hermans
  • Manfred Ballas
  • Zacharie Brahmi
  • Ernette du Toit
  • Robert Martell
  • Laurine Bow
  • Ronald Bontrop

There are no affiliations available

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