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Antigen Society #29 Report (DRw52)

  • C. J. Taylor
  • L. Ugozzoli
  • N. Tanigaki
  • R. Tosi
  • M. Bunce
  • A. Ting
  • G. B. Ferrara
Conference paper

Abstract

DRw52 was first recognized in the Seventh Workshop as a serologically defined group, seemingly cross-reactive with DR3, DR5, and Te50. In the Eighth Workshop this supertypic specificity, then called MT2, was shown to completely include DR3, 5, w6, w8, and DRw12 (then 8W13). The Ninth Workshop concluded that MT2 must be a member of the HLA-DR subset, although it might be on molecules other than those controlling the then designated HLA-DR specificities. MT2 was thought to be a supertypic antigen encoded by the DRB3 gene. On some haplotypes the gene product was expressed as a separate molecule to that of the private HLA-DR antigen encoded by the DRB1 gene. Thus, the MT2 specificity was formally designated DRw52. The high number was chosen to separate it from the subtypic HLA-DR specificities. More recently, heterogeneity of DRw52 has been defined by molecular,1 , biochemical,2 , cellular,1 , and serologic,3 analyses. It is now clear that DRw52 represents multiple epitopes that can be carried on the DRB1 and/or DRB3 gene products (Table 1).

Keywords

DRB3 Gene Antibody Population Serologic Profile Direct Binding Assay DRB4 Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Termijtelen A, Tilanus MGJ, Engelen I, Koning F, van-Rood JJ. Molecular localization of LB-Q1, a DRw52-like T-cell recognition epitope and identification at the genomic level of associated shared hybridizing fragments. Hum Immunol 1987; 19: 255.PubMedCrossRefGoogle Scholar
  2. 2.
    Fuggle SV, Carter C, Watts F, Kirkley J, Morris PJ. Monoclonal antibody definition of multiple polymorphic epitopes on HLA-DRw52. Hum Immunol 1987; 20: 249.PubMedCrossRefGoogle Scholar
  3. 3.
    Berte CC, Tanigaki N, Tosi R, Gorski J, Mach B. Serological recognition of HLA-DR allodeterminant corresponding to DNA sequence involved in gene conversion. Immunogenetics 1988; 27: 167.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York 1989

Authors and Affiliations

  • C. J. Taylor
  • L. Ugozzoli
  • N. Tanigaki
  • R. Tosi
  • M. Bunce
  • A. Ting
  • G. B. Ferrara

There are no affiliations available

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