Specificity Analysis of DQA Fragments in Core Cell Lines

  • Miriam Segall
  • A. Ando
  • K. W. J. Badenhoop
  • H. Betuel
  • H. Festenstein
  • L. Gebuhrer
  • C. Gorodezky
  • R. Heard
  • R. I. Lechler
  • E. Casilio-Lonardo
  • M. Maeda
  • D. P. Singal
  • H. Tokata
  • A. Zachary
Conference paper

Abstract

The polymorphic fragments identified in the core cell lines with the DQA probe and the various restriction enzymes are listed in Table 1. They are identified by enzyme, fragment size, and standard fragment number. The concordance (Con) value shows the reproducibility of the presence or absence of the fragment; 1 indicates no discrepancy for the two pairs of “hidden duplicates” among the DNA samples, 2 a discrepancy for one duplicate pair, 3 a discrepancy for both duplicate pairs, 99 that one or more of the duplicates could not be read for technical reasons. Fragments with similar presence/absence patterns are grouped together in clusters, which are discussed below. Strong antigen correlations are briefly indicated in Table 1; however, the fragment may also be positive (or negative) with DNA of cells not expressing the relevant specificity.

Keywords

Polymorphic Fragment Apparent Speci Cate Pair Strong Antigen Juvenile Diabetes Foundation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Spielman RS, Lee J, Bodmer WF, Bodmer JG, Trowsdale J. Six HLA-D region alpha-chain genes on human chromosome 6: polymorphisms and associations of DC alpha-related sequences with DR types. Proc Natl Acad Sci USA 1984; 81: 3461.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York 1989

Authors and Affiliations

  • Miriam Segall
  • A. Ando
  • K. W. J. Badenhoop
  • H. Betuel
  • H. Festenstein
  • L. Gebuhrer
  • C. Gorodezky
  • R. Heard
  • R. I. Lechler
  • E. Casilio-Lonardo
  • M. Maeda
  • D. P. Singal
  • H. Tokata
  • A. Zachary

There are no affiliations available

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