Abstract
DRw8 was recognized in its entirety by a single Workshop clone (6061), a DR-specific clone, which also recognizes DRw16 (Fig.1). The Dw8.1, 8.2, and 8.3 subsets could each be defined using combinations of Tenth Workshop clones. The Dw8.1 subgroup was rec ognized by two clones (7007 and 6040) that exhibited reactivity only with Dw8.1 cell lines. (Clone 6040 was not tested with Dw8.2 cell lines.) These clones were blocked by anti-DR antibodies, and did not react with Dw8.3 cell lines. The DR β chains of Dw8.1 and Dw8.3 are indistinguishable by two-dimensional gel analysis (1), but differ by a single amino acid (2). Dw8.1 may contain at least two subtypes based on differential recog- nition of cell line 9068 (BM9) versus cell lines 9067 (BTB) and 9069 (MADURA). Several clones including 6009, 7004, and 7028 (many of which are specific for HLA-DR molecules) differentially recognized these two Dw8.1 groups. In other instances, Dw8.1 appeared to split in a different manner. Clones 7022 and 6012, both blocked by anti-DR antibodies recognized 9067 (BTB) versus 9068 (BM9) and 9069 (MADURA), respectively.
Panicipating Laboratories: JAPAIZ,1 US2MBC2US2BAC,3NCYNIK,4USlDUQ,5ANZBSH,6US7NFL7
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Tajima, Y. et al. (1989). DRw8 and DQw4: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop. In: Dupont, B. (eds) Immunobiology of HLA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3552-1_110
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DOI: https://doi.org/10.1007/978-1-4612-3552-1_110
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