Abstract
HLA-DR4 is one of the most heterogeneous of the serologically defined HLA class II specificities. Sequence analyses (1) of the HLA-D subtypes of DR4 indicate that the amino acid sequences of Dw4, Dw10, Dw13, Dw14, Dw15, and DKT2 are identical from residues 1 through 56 of the DR β-I molecule, with the single exception of a Y → S substitution at position 37 in DKT2 (Fig. 1). Eight T-cell clones were submitted to the Tenth Interna- tional Workshop which recognized polymorphisms of HLA-DR4, and these clustered into four groups: 1) those recognizing Dw4 (clones 6026, 6096, and 6099), 2) those recognizing Dw13 and DKT2 (clones 6001 and 6006), 3) those recognizing Dw14 (clones 6010 and 6078), and 4) a single clone (6097) recognizing Dw1O. Additionally, clone 6021 recognized cells typing as Dw4, Dw10, Dw13, and Dw14. The reactivities of these clones are illustrated in Figure 1.
Participating Laboratory: UKIBAT,1 SCATSB,2 NCYZIE,3 USIMBC,4 FRAOHA,5 GERGOL,6 US7HAN,7 US7NFL,8
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Sharrock, C. et al. (1989). DR4 and DQw3: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop. In: Dupont, B. (eds) Immunobiology of HLA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3552-1_106
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DOI: https://doi.org/10.1007/978-1-4612-3552-1_106
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