DR4 and DQw3: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop

  • C. Sharrock
  • K. Lundin
  • K. Zier
  • A. Zeevi
  • M. Thomsen
  • T. Eiermann
  • J. A. Hansen
  • E. Mickelson
  • N. Flomenberg

Abstract

HLA-DR4 is one of the most heterogeneous of the serologically defined HLA class II specificities. Sequence analyses (1) of the HLA-D subtypes of DR4 indicate that the amino acid sequences of Dw4, Dw10, Dw13, Dw14, Dw15, and DKT2 are identical from residues 1 through 56 of the DR β-I molecule, with the single exception of a Y → S substitution at position 37 in DKT2 (Fig. 1). Eight T-cell clones were submitted to the Tenth Interna- tional Workshop which recognized polymorphisms of HLA-DR4, and these clustered into four groups: 1) those recognizing Dw4 (clones 6026, 6096, and 6099), 2) those recognizing Dw13 and DKT2 (clones 6001 and 6006), 3) those recognizing Dw14 (clones 6010 and 6078), and 4) a single clone (6097) recognizing Dw1O. Additionally, clone 6021 recognized cells typing as Dw4, Dw10, Dw13, and Dw14. The reactivities of these clones are illustrated in Figure 1.

Keywords

Tral Teta 

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Copyright information

© Springer-Verlag New York 1989

Authors and Affiliations

  • C. Sharrock
  • K. Lundin
  • K. Zier
  • A. Zeevi
  • M. Thomsen
  • T. Eiermann
  • J. A. Hansen
  • E. Mickelson
  • N. Flomenberg

There are no affiliations available

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