Carcinoma of the Duodenum

  • Heidrun Rotterdam
  • Horatio T. Enterline


Primary duodenal carcinoma is rare, and only approximately 700 cases had been reported in the literature by 1974 (i.e., within the two centuries following the first description in 1746).1 The files of the Mayo Clinic contained 104 cases for the 40-year period from 1937 to 1977,2 yielding an incidence of 2 to 3 cases per year. In the New York Hospital—Cornell Medical Center, only 32 cases were found in 38 years.3 The incidence at autopsy is between 0.019 and 0.5%.3 The proportion of duodenal carcinomas among gastrointestinal carcinomas is 0.35%.4 Interestingly, however, the duodenum is the preferential site of origin of small intestinal carcinomas, 33 to 45% of which arise there, according to data collected between 1937 and 1963.5 More recent reviews of small intestinal carcinomas yield still higher incidences of 48 and 54%.6,7 As Jefferson8 said in 1916, “Inch for inch the duodenum is more liable to cancer than the rest of the small intestine.” Carcinoma accounts for 70 to 80% of all duodenal malignant tumors; the remainder includes lymphoma, leiomyosarcoma, and carcinoid tumor.1


Obstructive Jaundice Ampullary Carcinoma Cervical Squamous Cell Carcinoma Ampullary Tumor Heterotopic Pancreas 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Heidrun Rotterdam
    • 1
  • Horatio T. Enterline
    • 2
  1. 1.Department of PathologyUniversity Hospital, New York University Medical CenterNew YorkUSA
  2. 2.Hospital of the University of Pennsylvania Medical SchoolPhiladelphiaUSA

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